Multiomic immune clockworks of pregnancy.
Cytomics
Immunology
Mass cytometry
Metabolomics
Microbiome
Pregnancy
Prematurity
Preterm birth
Proteomics
Transcriptomics
multiomics
parturition
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
26
07
2019
accepted:
31
10
2019
pubmed:
6
2
2020
medline:
25
5
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy "immune clock" is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth.
Identifiants
pubmed: 32020337
doi: 10.1007/s00281-019-00772-1
pii: 10.1007/s00281-019-00772-1
pmc: PMC7508753
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-412Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL139844
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD086253
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
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