Connection between seminiferous tubules and epididymal duct is originally induced before sex differentiation in a sex-independent manner.
efferent duct
male reproductive tract
sequential immunohistochemistry
testis development
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
23
08
2019
revised:
03
01
2020
accepted:
07
01
2020
pubmed:
6
2
2020
medline:
27
7
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Spermatozoa in mammals develop in seminiferous tubules in a testis and are transported through the male reproductive tract. Their developmental origins are, however, different from each other; the seminiferous tubules are testicular (gonadal) structure but the subsequent ducts stem from the mesonephros. Although some mechanisms should function for the connection between these ducts, there are few reports on them. In the present study, basic information such as timing, localization, and cell types involved in the connection was obtained by sequential immunohistochemistry. At the time when the undifferentiated gonad differentiates into the testis or ovary, Adrenal-4 binding protein/steroidogenic factor-1 (Ad4BP/SF-1)-positive gonadal cells were noted in the mesonephric tubules (MT) in both sexes. At an earlier stage, although Ad4BP/SF-1-positive coelomic epithelial cells were adjacent to the MT, a basal membrane around them was not observed. The connection between the testis cords and MT is suggested to be induced between Ad4BP/SF-1-positive gonadal cells and the MT before sex differentiation in a sex-independent manner.
Sections du résumé
BACKGROUND
Spermatozoa in mammals develop in seminiferous tubules in a testis and are transported through the male reproductive tract. Their developmental origins are, however, different from each other; the seminiferous tubules are testicular (gonadal) structure but the subsequent ducts stem from the mesonephros. Although some mechanisms should function for the connection between these ducts, there are few reports on them. In the present study, basic information such as timing, localization, and cell types involved in the connection was obtained by sequential immunohistochemistry.
RESULTS
At the time when the undifferentiated gonad differentiates into the testis or ovary, Adrenal-4 binding protein/steroidogenic factor-1 (Ad4BP/SF-1)-positive gonadal cells were noted in the mesonephric tubules (MT) in both sexes. At an earlier stage, although Ad4BP/SF-1-positive coelomic epithelial cells were adjacent to the MT, a basal membrane around them was not observed.
CONCLUSIONS
The connection between the testis cords and MT is suggested to be induced between Ad4BP/SF-1-positive gonadal cells and the MT before sex differentiation in a sex-independent manner.
Substances chimiques
Steroidogenic Factor 1
0
steroidogenic factor 1, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
754-764Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : KAKENHI Grant Number JP19K16483
Pays : International
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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