Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men.
Insulin clearance
Insulin resistance
Shape of glucose response curve
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
11
12
2019
revised:
15
01
2020
accepted:
30
01
2020
pubmed:
6
2
2020
medline:
7
7
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Individuals with a monophasic glucose response curve (GRC) during a 75-g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non-obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue-specific insulin sensitivity and insulin clearance using a two-step hyperinsulinemic-euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non-obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.
Identifiants
pubmed: 32020726
doi: 10.1111/jdi.13227
pmc: PMC7378447
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
874-877Subventions
Organisme : Mitsukoshi Welfare Foundation
Organisme : Diabetes Masters Conference
Organisme : Japan Diabetes Foundation
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : KAKENHI 23680069, 26282197, 17K19929
Organisme : Suzuken Memorial Foundation
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
Références
Diabetologia. 2012 Aug;55(8):2183-92
pubmed: 22584727
J Appl Physiol (1985). 1989 May;66(5):2206-10
pubmed: 2663816
Diabetes Care. 2003 Apr;26(4):1026-33
pubmed: 12663568
Nat Genet. 2002 Mar;30(3):270-6
pubmed: 11850617
J Clin Endocrinol Metab. 2019 Jun 1;104(6):2325-2333
pubmed: 30689902
Diabetes. 2019 Sep;68(9):1709-1716
pubmed: 31431441
Diabetes Care. 2016 Aug;39(8):1431-9
pubmed: 27293201
J Clin Endocrinol Metab. 2005 Jun;90(6):3191-6
pubmed: 15769987
Diabetes Metab Res Rev. 2010 May;26(4):280-6
pubmed: 20503260
Physiology (Bethesda). 2019 May 1;34(3):198-215
pubmed: 30968756
Sci Rep. 2017 May 3;7(1):1462
pubmed: 28469173
J Clin Endocrinol Metab. 2016 Oct;101(10):3676-3684
pubmed: 27383116
Metabolism. 2017 May;70:42-50
pubmed: 28403944