Visual spatial learning outcomes for clinical trials in neurofibromatosis type 1.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
04
09
2019
revised:
17
12
2019
accepted:
18
12
2019
pubmed:
6
2
2020
medline:
11
11
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the "Arena Maze", a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.
Identifiants
pubmed: 32022434
doi: 10.1002/acn3.50976
pmc: PMC7034508
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Lovastatin
9LHU78OQFD
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-249Subventions
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States
Organisme : Children's Tumor Foundation
Pays : International
Organisme : Department of Defense Neurofibromatosis Research Program
ID : W81XWH-05-1-0615
Pays : International
Organisme : Office of the Congressionally Directed Medical Research Programs
Pays : International
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
Organisme : United States Army Medical Research and Materiel Command
Pays : International
Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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