Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-analysis.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
6
2
2020
medline:
4
7
2020
entrez:
6
2
2020
Statut:
ppublish
Résumé
To conduct a systematic review and meta-analysis that defines the worldwide incidence of celiac disease (CD) and examines temporal trends. MEDLINE and EMBASE were searched for population-based studies reporting the incidence of CD in the overall population, children, or adults. No limits were placed on year or language of publication. Studies solely examining at-risk populations (e.g., patients with type 1 diabetes) were excluded. Random-effects models were performed to meta-analyze sex- and age-specific incidence in the 21st century. Temporal trend analyses assessed the average annual percent change in CD incidence over time. Of 11,189 citations, 86 eligible studies were identified for inclusion, of which 50 were deemed suitable for analyses. In the 21st century, the pooled female incidence of CD was 17.4 (95% confidence interval [CI]: 13.7, 21.1) (I = 99.5%) per 100,000 person-years, compared with 7.8 (95% CI: 6.3, 9.2) (I = 98.6%) in males. Child-specific incidence was 21.3 per 100,000 person-years (95% CI: 15.9, 26.7) (I = 99.7%) compared with 12.9 (95% CI: 7.6, 18.2) (I = 99.9%) in adults. Pooling average annual percent changes showed the incidence of CD to be increasing by 7.5% (95% CI: 5.8, 9.3) (I = 79.6%) per year over the past several decades. Incidence of CD is highest in females and children. Overall, the incidence has been significantly rising in the latter half of the 20th century and into the 21st century throughout the Western world. Population-based studies in Africa, Asia, and Latin America are needed to provide a comprehensive picture of the global incidence of CD.
Identifiants
pubmed: 32022718
doi: 10.14309/ajg.0000000000000523
pii: 00000434-202004000-00009
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-525Références
Singh P, Arora A, Strand TA, et al. Global prevalence of celiac disease: Systematic review and meta-analysis. Clin Gastroenterol Hepatol 2018;16(6):823–36.e2.
Kang JY, Kang AH, Green A, et al. Systematic review: Worldwide variation in the frequency of coeliac disease and changes over time. Aliment Pharmacol Ther 2013;38(3):226–45.
Altobelli E, Paduano R, Petrocelli R, et al. Burden of celiac disease in Europe: A review of its childhood and adulthood prevalence and incidence as of September 2014. Ann Ig 2014;26(6):485–98.
Choung RS, Larson SA, Khaleghi S, et al. Prevalence and morbidity of undiagnosed celiac disease from a community-based study. Gastroenterology 2017;152(4):830–9.e5.
Choung RS, Unalp-Arida A, Ruhl CE, et al. Less hidden celiac disease but increased gluten avoidance without a diagnosis in the United States: Findings from the National Health and Nutrition Examination Surveys from 2009 to 2014. Mayo Clin Proc 2017;92(1):30–8.
Shah S, Akbari M, Vanga R, et al. Patient perception of treatment burden is high in celiac disease compared with other common conditions. Am J Gastroenterol 2014;109(9):1304–11.
Missbach B, Schwingshackl L, Billmann A, et al. Gluten-free food database: The nutritional quality and cost of packaged gluten-free foods. PeerJ 2015;3:e1337.
Pourhoseingholi MA, Rostami-Nejad M, Barzegar F, et al. Economic burden made celiac disease an expensive and challenging condition for Iranian patients. Gastroenterol Hepatol Bed Bench 2017;10(4):258–62.
Koerner TB, Cleroux C, Poirier C, et al. Gluten contamination of naturally gluten-free flours and starches used by Canadians with celiac disease. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2013;30(12):2017–21.
Farage P, de Medeiros Nobrega YK, Pratesi R, et al. Gluten contamination in gluten-free bakery products: A risk for coeliac disease patients. Public Health Nutr 2017;20(3):413–6.
Ciacci C, Zingone F. The perceived social burden in celiac disease. Diseases 2015;3(2):102–10.
King JA, Kaplan GG, Godley J. Experiences of coeliac disease in a changing gluten-free landscape. J Hum Nutr Diet 2019;32(1):72–9.
Ludvigsson JF. Mortality and malignancy in celiac disease. Gastrointest Endosc Clin N Am 2012;22(4):705–22.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000;283(15):2008–12.
GA Wells BS, O'Connell D, Peterson J, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses (http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp). Accessed September 10, 2017.
Grode L, Bech BH, Jensen TM, et al. Prevalence, incidence, and autoimmune comorbidities of celiac disease: A nation-wide, population-based study in Denmark from 1977 to 2016. Eur J Gastroenterol Hepatol 2018;30(1):83–91.
Sher KS, Fraser RC, Wicks AC, et al. High risk of coeliac disease in Punjabis: Epidemiological study in the South Asian and European populations of Leicestershire. Digestion 1993;54(3):178–82.
Fowell AJ, Thomas PW, Surgenor SL, et al. The epidemiology of coeliac disease in East Dorset 1993-2002: An assessment of the “coeliac iceberg”, and preliminary evidence of case clustering. QJM 2006;99(7):453–60.
Hawkes ND, Swift GL, Smith PM, et al. Incidence and presentation of coeliac disease in South Glamorgan. Eur J Gastroenterol Hepatol 2000;12(3):345–9.
Hurley JJ, Lee B, Turner JK, et al. Incidence and presentation of reported coeliac disease in Cardiff and the Vale of Glamorgan: The next 10 years. Eur J Gastroenterol Hepatol 2012;24(5):482–6.
West J, Fleming KM, Tata LJ, et al. Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: Population-based study. Am J Gastroenterol 2014;109(5):757–68.
Corrao G, Usai P, Galatola G, et al. Estimating the incidence of coeliac disease with capture-recapture methods within four geographic areas in Italy. J Epidemiol Community Health 1996;50(3):299–305.
Lanzarotto F, Crimi F, Amato M, et al. Is under diagnosis of celiac disease compounded by mismanagement in the primary care setting? A survey in the Italian Province of Brescia. Minerva Gastroenterol Dietol 2004;50(4):283–8.
Lanzini A, Villanacci V, Apillan N, et al. Epidemiological, clinical and histopathologic characteristics of celiac disease: Results of a case-finding population-based program in an Italian community. Scand J Gastroenterol 2005;40(8):950–7.
Angeli G, Pasquini R, Panella V, et al. An epidemiologic survey of celiac disease in the Terni area (Umbria, Italy) in 2002-2010. J Prev Med Hyg 2012;53(1):20–3.
Zingone F, West J, Auricchio R, et al. Incidence and distribution of coeliac disease in Campania (Italy): 2011-2013. United European Gastroenterol J 2015;3(2):182–9.
Gutschmidt S, Sandforth F, Janicke I, et al. Incidence of endemic sprue in Berlin (West): A retrospective study based on biopsy findings. Z Gastroenterol 1987;25(10):662–7.
Jansen TLA, Mulder CJJ, Karssen PHZ, et al. Epidemiological survey of the Dutch Coeliac Disease Society: An update 1992. Eur J Gastroenterol Hepatol 1993;5(2):73–8.
Burger JP, Roovers EA, Drenth JP, et al. Rising incidence of celiac disease in the Netherlands: An analysis of temporal trends from 1995 to 2010. Scand J Gastroenterol 2014;49(8):933–41.
Ussher R, Yeong ML, Stace N. Coeliac disease: Incidence and prevalence in Wellington 1985-92. N Z Med J 1994;107(978):195–7.
Cook B, Oxner R, Chapman B, et al. A thirty-year (1970-1999) study of coeliac disease in the Canterbury region of New Zealand. N Z Med J 2004;117(1189):U772.
Stewart M, Andrews CN, Urbanski S, et al. The association of coeliac disease and microscopic colitis: A large population-based study. Aliment Pharmacol Ther 2011;33(12):1340–9.
Murray JA, Van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol 2003;1(1):19–27.
Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing incidence of celiac disease in a North American population. Am J Gastroenterol 2013;108(5):818–24.
Dydensborg S, Toftedal P, Biaggi M, et al. Increasing prevalence of coeliac disease in Denmark: A linkage study combining national registries. Acta Paediatr 2012;101(2):179–84.
Ress K, Luts K, Rago T, et al. Nationwide study of childhood celiac disease incidence over a 35-year period in Estonia. Eur J Pediatr 2012;171(12):1823–8.
Kivela L, Kaukinen K, Lahdeaho ML, et al. Presentation of celiac disease in Finnish children is no longer changing: A 50-year perspective. J Pediatr 2015;167(5):1109–15.e1.
Perminow G, Rydning A, Jacobsen CD, et al. Gastrointestinal endoscopy in children. Tidsskr Nor Laegeforen 2000;120(29):3503–6.
Beitnes AR, Vikskjold FB, Johannesdottir GB, et al. Symptoms and mucosal changes stable during rapid increase of pediatric celiac disease in Norway. J Pediatr Gastroenterol Nutr 2017;64(4):586–91.
Namatovu F, Sandström O, Olsson C, et al. Celiac disease risk varies between birth cohorts, generating hypotheses about causality: Evidence from 36 years of population-based follow-up. BMC Gastroenterol 2014;14:59.
Tapsas D, Hollén E, Stenhammar L, et al. Unusually high incidence of paediatric coeliac disease in Sweden during the period 1973 - 2013. PLoS One 2015;10(12):e0144346.
White LE, Merrick VM, Bannerman E, et al. The rising incidence of celiac disease in Scotland. Pediatrics 2013;132(4):e924–31.
Whyte LA, Jenkins HR. The epidemiology of coeliac disease in South Wales: A 28-year perspective. Arch Dis Child 2013;98(6):405–7.
Zingone F, West J, Crooks CJ, et al. Socioeconomic variation in the incidence of childhood coeliac disease in the UK. Arch Dis Child 2015;100(5):466–73.
Lister M, Wood P, Henderson P, et al. The rising incidence of childhood coeliac disease: A 7-year regional cohort study. Paper presented at: Coeliac UK's Research Conference 2018, 2018; London, UK.
Lopez-Rodriguez MJ, Canal Macias ML, Lavado Garcia JM, et al. Epidemiological changes in diagnosed coeliac disease in a population of Spanish children. Acta Paediatr 2003;92(2):165–9.
Cilleruelo ML, Roman-Riechmann E, Sanchez-Valverde F, et al. Spanish national registry of celiac disease: Incidence and clinical presentation. J Pediatr Gastroenterol Nutr 2014;59(4):522–6.
Vukavic T. The incidence of coeliac disease in children born on the territory of Voyvodina (Serbia): Coeliac disease register 1980-1993. Arch Gastroenterohepatol 1995;14(1-2):1–3.
Van Kalleveen MW, de Meij T, Plotz FB. Clinical spectrum of paediatric coeliac disease: A 10-year single-centre experience. Eur J Pediatr 2018;177(4):593–602.
McGowan KE, Castiglione DA, Butzner JD. The changing face of childhood celiac disease in North America: Impact of serological testing. Pediatrics 2009;124(6):1572–8.
Rajani S, Huynh HQ, Turner J. The changing frequency of celiac disease diagnosed at the Stollery Children's Hospital. Can J Gastroenterol 2010;24(2):109–12.
Stewart MJ, Shaffer E, Urbanski SJ, et al. The association between celiac disease and eosinophilic esophagitis in children and adults. BMC Gastroenterol 2013;13:96.
Almallouhi E, King KS, Patel B, et al. Increasing incidence and altered presentation in a population-based study of pediatric celiac disease in North America. J Pediatr Gastroenterol Nutr 2017;65(4):432–7.
Bode S, Gudmand-Hoyer E. Incidence and prevalence of adult coeliac disease within a defined geographic area in Denmark. Scand J Gastroenterol 1996;31(7):694–9.
Schosler L, Christensen LA, Hvas CL. Symptoms and findings in adult-onset celiac disease in a historical Danish patient cohort. Scand J Gastroenterol 2016;51(3):288–94.
Collin P, Reunala T, Rasmussen M, et al. High incidence and prevalence of adult coeliac disease augmented diagnostic approach. Scand J Gastroenterol 1997;32(11):1129–33.
Collin P, Huhtala H, Virta L, et al. Diagnosis of celiac disease in clinical practice: Physician's alertness to the condition essential. J Clin Gastroenterol 2007;41(2):152–6.
Virta LJ, Kaukinen K, Collin P. Incidence and prevalence of diagnosed coeliac disease in Finland: Results of effective case finding in adults. Scand J Gastroenterol 2009;44(8):933–8.
Virta LJ, Saarinen MM, Kolho KL. Declining trend in the incidence of biopsy-verified coeliac disease in the adult population of Finland, 2005-2014. Aliment Pharmacol Ther 2017;46(11-12):1085–93.
Tosic Z, Salkic N, Krizic N, et al. Celiac disease in adult population in Tuzla region of Bosnia and Herzegovina: A 3-year surveillance (2007-2009). Med Arch 2013;67(5):333–5.
Fernandez A, Gonzalez L, de-la-Fuente J. Coeliac disease: Clinical features in adult populations. Rev Esp Enferm Dig 2010;102(8):466–71.
Olsson C, Stenlund H, Hornell A, et al. Regional variation in celiac disease risk within Sweden revealed by the nationwide prospective incidence register. Acta Paediatr 2009;98(2):337–42.
Midhagen G, Järnerot G, Kraaz W. Adult coeliac disease within a defined geographic area in Sweden: A study of prevalence and associated diseases. Scand J Gastroenterol 1988;23(8):1000–4.
Stroud C, Almilaji O, Nicholas D, et al. Evolving patterns in the presentation of coeliac disease over the last 25 years. Frontline Gastroenterol 2019;0:1–6.
West J, Otete H, Sultan AA, et al. Changes in testing for and incidence of celiac disease in the United Kingdom: A population-based cohort study. Epidemiology 2019;30(4):e23–4.
Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3(7):797–801.
Chorzelski TP, Sulej J, Tchorzewska H, et al. IgA class endomysium antibodies in dermatitis herpetiformis and coeliac disease. Ann NY Acad Sci 1983;420:325–34.
Meeuwisse G. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970;59:461–3.
Walker-Smith J, Guandalini S, Schmitz J, et al. Revised criteria for diagnosis of coeliac disease: Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990;65(8):909–11.
Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40(1):1–19.
Husby S, Koletzko S, Korponay-Szabo IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012;54(1):136–60.
Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol 2015;12(10):561–71.
Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013;62(1):43–52.
Pham-Short A, Donaghue KC, Ambler G, et al. Screening for celiac disease in type 1 diabetes: A systematic review. Pediatrics 2015;136(1):e170–6.
Singh P, Arora S, Lal S, et al. Risk of celiac disease in the first- and second-degree relatives of patients with celiac disease: A systematic review and meta-analysis. Am J Gastroenterol 2015;110(11):1539–48.
Quan J, Panaccione N, King JA, et al. Association between celiac disease and autism spectrum disorder: A systematic review. J Can Assoc Gastroenterol 2019;2(Suppl 2):502–3.
Salinas M, Lopez-Garrigos M, Flores E, et al. Big differences in primary care celiac disease serological markers request in Spain. Biochem Med 2017;27(1):231–6.
Evans KE, Malloy AR, Gorard DA. Changing patterns of coeliac serology requests. Aliment Pharmacol Ther 2009;29(10):1137–42.
Copelton DA, Valle G. “You don't need a prescription to go gluten-free”: The scientific self-diagnosis of celiac disease. Soc Sci Med 2009;69(4):623–31.
Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009;137(1):88–93.
Lebwohl B, Tennyson CA, Holub JL, et al. Sex and racial disparities in duodenal biopsy to evaluate for celiac disease. Gastrointest Endosc 2012;76(4):779–85.
Katz KD, Rashtak S, Lahr BD, et al. Screening for celiac disease in a North American population: Sequential serology and gastrointestinal symptoms. Am J Gastroenterol 2011;106(7):1333–9.
Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 2018;14(5):301–16.
Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007;26(9):1217–25.
Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42(7):530–8.
Namatovu F, Lindkvist M, Olsson C, et al. Season and region of birth as risk factors for coeliac disease a key to the aetiology? Arch Dis Child 2016;101(12):1114–8.
Namatovu F, Olsson C, Lindkvist M, et al. Maternal and perinatal conditions and the risk of developing celiac disease during childhood. BMC Pediatr 2016;16:77.
Namatovu F, Stromgren M, Ivarsson A, et al. Neighborhood conditions and celiac disease risk among children in Sweden. Scand J Public Health 2014;42(7):572–80.
Ivarsson A. The Swedish epidemic of coeliac disease explored using an epidemiological approach—Some lessons to be learnt. Best Pract Res Clin Gastroenterol 2005;19(3):425–40.
Myleus A, Ivarsson A, Webb C, et al. Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic. J Pediatr Gastroenterol Nutr 2009;49(2):170–6.
Dydenborg Sander S, Nybo Andersen AM, Murray JA, et al. Association between antibiotics in the first year of life and celiac disease. Gastroenterology 2019;156(8):2217–29.
Bach JF. The hygiene hypothesis in autoimmunity: The role of pathogens and commensals. Nat Rev Immunol 2018;18(2):105–20.
Kondrashova A, Mustalahti K, Kaukinen K, et al. Lower economic status and inferior hygienic environment may protect against celiac disease. Ann Med 2008;40(3):223–31.
Myléus A, Hernell O, Gothefors L, et al. Early infections are associated with increased risk for celiac disease: An incident case-referent study. BMC Pediatr 2012;12:194.
Mårild K, Ye W, Lebwohl B, et al. Antibiotic exposure and the development of coeliac disease: A nationwide case-control study. BMC Gastroenterol 2013;13:109.
Marild K, Stephansson O, Montgomery S, et al. Pregnancy outcome and risk of celiac disease in offspring: A nationwide case-control study. Gastroenterology 2012;142(1):39–45.e3.
Unalp-Arida A, Ruhl CE, Choung RS, et al. Lower prevalence of celiac disease and gluten-related disorders in persons living in southern vs northern latitudes of the United States. Gastroenterology 2017;152(8):1922–32.e2.
Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet 2018;390(10114):2769–78.
Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis: A systematic review of population-based studies. Ann Surg 2017;266(2):237–41.
Blackett JW, Shamsunder M, Reilly NR, et al. Characteristics and comorbidities of inpatients without celiac disease on a gluten-free diet. Eur J Gastroenterol Hepatol 2018;30(4):477–83.
Kim HS, Patel KG, Orosz E, et al. Time trends in the prevalence of celiac disease and gluten-free diet in the US population: Results from the National Health and Nutrition Examination Surveys 2009-2014. JAMA Intern Med 2016;176(11):1716–7.
Egger M, Davey-Smith G, Schneider M. Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd ed. London: BMJ Publishing Group; 2008.
Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet 2018;391(10115):70–81.