Low dose of isotretinoin: A comprehensive review.
dermatology
low-dose isotretinoin
safety
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
14
11
2019
revised:
04
01
2020
accepted:
03
02
2020
pubmed:
6
2
2020
medline:
15
5
2021
entrez:
6
2
2020
Statut:
ppublish
Résumé
Isotretinoin is a first-generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti-inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date-unlimited PubMed search, from inception till December 2019, using the following search terms: "low-dose isotretinoin" and "dermatology," "isotretinoin and safety," "isotretinoin, off-label uses," "isotretinoin and male fertility," "isotretinoin, iPLEDGE system," aiming to deliver a therapeutic update relevant to clinical practice. All English-language articles were considered with no limitation based on the articles' type. Low-dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.
Substances chimiques
Dermatologic Agents
0
Retinoids
0
Isotretinoin
EH28UP18IF
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13251Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
Abdelmaksoud, A., Vojvodic, A., Ayhan, E., Dönmezdil, S., Jovicevic, T. V., Vojvodic, P., … Vestita, M. (2019). Depression, isotretinoin, and folic acid: A practical review. Dermatologic Therapy, 6, e13104. https://doi.org/10.1111/dth.13104
Abraham, S., & Piguet, V. (2006). An unusual presentation of malassezia dermatosis. Dermatology, 212(1), 4-6.
Acmaz, G., Cınar, L., Acmaz, B., Aksoy, H., Kafadar, Y. T., Madendag, Y., … Muderris, I. (2019). The effects of Oral Isotretinoin in women with acne and polycystic ovary syndrome. BioMed Research International, 7, 2513067.
Akoglu, G., Boztepe, G., & Karaduman, A. (2006). Prurigo pigmentosa successfully treated with low-dose isotretinoin. Dermatology, 213, 331-333.
Akoglu, G., Emre, S., Sungu, N., Kurtoglu, G., & Metin, A. (2013). Clinicopathological features of 25 patients with acquired perforating dermatosis. European Journal of Dermatology, 23, 864-871.
Aktas, H., Ertugrul, G., Parlak, M., & Unal, M. (2019). Long-term isotretinoin use does not cause parenchymal liver change: Ultrasonographic study in 50 patients. Dermatologic Therapy, 32(5), e13012.
Al-Hamamy, H. R., Salman, H. A., & Abdulsattar, N. A. (2012). Treatment of plane warts with a low-dose oral isotretinoin. ISRN Dermatology, 2012, 163929.
Al-Sudany, N. K., Mohammed, N. H., & Alrifai, S. B. (2019). Down-regulation of S100a7a antimicrobial peptide in acne vulgaris patients after isotretinoin therapy. Dermatologic Therapy, 32(6), e13136. https://doi.org/10.1111/dth.13136
Altıntaş Aykan, D., & Ergün, Y. (2019). Isotretinoin: Still the cause of anxiety for teratogenicity. Dermatologic Therapy, 14, e13192. https://doi.org/10.1111/dth.13192
Amory, J. K., Ostrowski, K. A., Gannon, J. R., Berkseth, K., Stevison, F., Isoherranen, N., … Walsh, T. (2017). Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: A pilot study. Andrology, 5, 1115-1123.
Andrade, F. M. X., Picosse, F. R., Cunha, L. P. D., Valente, C. M., Bezerra, F. M., Miot, H., … Freitas, D. (2019). Ocular surface changes in the treatment of rosacea: Comparison between low-dose oral isotretinoin and doxycycline. Arquivos Brasileiros de Oftalmologia pii: S0004-27492019005018102. https://doi.org/10.5935/0004-2749.20200016
Arora S, Malik A, Kumar D, Sodhi N. 2016. Hepatitis B, interferon, and acne fulminans in a young girl. Indian Dermatology Online JournalMar-Apr;7(2):93-5.
Atacan, D., Ergin, C., Çelik, G., Gönül, M., & Adabağ, A. (2016). Oral isotretinoin: A new treatment alternative for generalized lichen amyloidosis. The Australasian Journal of Dermatology, 57, 246-247.
Ayhan, E. (2016). Lymphangioma circumscriptum: Good clinical response to isotretinoin therapy. Pediatric Dermatology, 33, e208-e209.
Babahosseini, H., Tavakolpour, S., Mahmoudi, H., Balighi, K., Teimourpour, A., Ghodsi, S. Z., … Daneshpazhooh, M. (2019). Lichen planopilaris: Retrospective study on the characteristics and treatment of 291 patients. The Journal of Dermatological Treatment, 30(6), 598-604.
Bagatin, E. (2010). Oral isotretinoin: The most promising dermatological off-label uses. Expert Review of Dermatology, 5(6), 617-626.
Barańska-Rybak, W., Mehrholz, D., Flis, P., Karpinsky, G., & Sokołowska-Wojdyło, M. (2019). Severe acne fulminans following low-dose isotretinoin and testosterone use. Cutis, 103(6), E20-E21.
Barbieri, J. S., Frieden, I. J., & Nagler, A. R. (2019). Isotretinoin, patient safety, and patient-centered care-time to reform iPLEDGE. JAMA Dermatology. https://doi.org/10.1001/jamadermatol.2019.3270
Barbieri, J. S., Spaccarelli, N., Margolis, D. J., & James, W. D. (2019). Approaches to limit systemic antibiotic use in acne: Systemic alternatives, emerging topical therapies, dietary modification, and laser and light-based treatments. Journal of the American Academy of Dermatology, 80(2), 538-549.
Benhadou, F., Van der Zee, H. H., Pascual, J. C., Rigopoulos, D., Katoulis, A., Liakou, A. I., … Guillem, P. (2019). Pilonidal sinus disease: An intergluteal localization of hidradenitis suppurativa/acne inversa: A cross-sectional study among 2465 patients. The British Journal of Dermatology, 181(6), 1198-1206.
Bocquet-Trémoureux, S., Corvec, S., Khammari, A., Dagnelie, M. A., Boisrobert, A., & Dreno, B. (2019). Acne fulminans and Cutibacterium acnes phylotypes. Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.16064
Borovaya, A., Dombrowski, Y., Zwicker, S., Olisova, O., Ruzicka, T., Wolf, R., … Sárdy, M. (2014). Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Archives of Dermatological Research, 306, 689-700.
Botsali, A., Kocyigit, P., & Uran, P. (2019). The effects of Isotretinoin on affective and cognitive functions are disparate in adolescent acne vulgaris patients. Journal of Dermatologic Treatment, 15, 1-17. https://doi.org/10.1080/09546634.2019.1606396
Caposiena Caro, R. D., & Bianchi, L. (2019). Can retinoids flare hidradenitis suppurativa? A further case series. Clinical and Experimental Dermatology, 44(4), e153-e154.
Çinar, L., Kartal, D., Ergin, C., Aksoy, H., Karadag, M. A., Aydin, T., … Borlu, M. (2016). The effect of systemic isotretinoin on male fertility. Cutaneous and Ocular Toxicology, 35, 296-299.
Damevska, K., Pollozhani, N., Neloska, L., & Duma, S. (2017). Unsuccessful treatment of progressive macular hypomelanosis with oral isotretinoin. Dermatologic Therapy, 30(5). https://doi:10.1111/dth.12514
Daunton, A., Oyebode, F., & Goulding, J. M. R. (2019). Depression and the dermatologist: A critical analysis of contemporary isotretinoin prescribingpractices. Clinical and Experimental Dermatology, 44(8), 903-905. https://doi.org/10.1111/ced.13971
Dave, D. D., & Abdelmaksoud, A. (2018). Low dose isotretinoin for pigmented post-varicella scars. Dermatologic Therapy, 32(1), e12768.
Dave, D. D., & Abdelmaksoud, A. (2019). Low dose isotretinoin as an adjuvant therapy for treatment of different clinical variants of warts: A case series. Dermatologic Therapy, 32, e12836.
de Souza Leão Kamamoto, C., Sanudo, A., Hassun, K. M., & Bagatin, E. (2017). Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: A randomized comparative trial. International Journal of Dermatology, 56, 80-85.
De Vita, V., & Melnik, B. C. (2017). The magnitude of mTORC1 Signalling may predict the response to Isotretinoin treatment in patients with Hidradenitis Suppurativa. Dermatology, 233(5), 399-400.
Dhaked, D. R., Meena, R. S., Maheshwari, A., Agarwal, U. S., & Purohit, S. (2016). A randomized comparative trial of two low-dose oral isotretinoin regimens in moderate to severe acne vulgaris. Indian Dermatology Online Journal, 7, 378-385.
Dispenza, M. C., Wolpert, E. B., Gilliland, K. L., Dai, J. P., Cong, Z., Nelson, A. M., & Thiboutot, D. M. (2012). Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responsesin acne patients. The Journal of Investigative Dermatology, 132, 2198-2205.
Droitcourt, C., Poizeau, F., Kerbrat, S., Balusson, F., Drezen, E., Happe, A., … Dupuy, A. (2019). Isotretinoin and risk factors for suicide attempt: A population-based comprehensive case series and nested case-control study using 2010-2014 French health insurance data. Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.16005
Dupuy, E., Alexanian, S., & Hsiao, J. (2018). Galli-Galli disease responsive to isotretinoin treatment. International Journal of Dermatology, 57, 1123-1124.
El Aziz Ragab, M. A., Omar, S. S., Collier, A., El-Wafa, R. A. H. A., & Gomaa, N. (2018). The effect of continuous high versus low dose oral isotretinoin regimens on dermcidin expression in patients with moderate to severe acne vulgaris. Dermatologic Therapy, 31, e12715.
Elshahid, A. R. M., Shahein, I. M., Mohammed, Y. F., Ismail, N. F., Zakarria, H. B. A. E., & GamalEl Din, S. F. (2019). Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: A case-control study. Andrology, 8(1), 148-153. https://doi.org/10.1111/andr.12672
Erkek, E., Ayva, S., Atasoy, P., & Emeksiz, M. C. (2009). Confluent and reticulated papillomatosis: Favourable response to low-dose isotretinoin. Journal of the European Academy of Dermatology and Venereology, 23, 1342-1343.
Faghihi, G., Mokhtari, F., Fard, N. M., Motamedi, N., & Hosseini, S. M. (2017). Comparing the efficacy of low dose and conventional dose of Oral Isotretinoin in treatment of moderate and severe acne vulgaris. Journal of Research in Pharmacy Practice, 6, 233-238.
Feily, A., Theri, T., Meier-Schiesser, B., Rhinehart, D. P., Sobhanian, S., MaricarmenColon-Diaz, A. F., & Ramirez-Fort, M. K. (2019). The effect of low-dose isotretinoin therapy on serum androgen levels in women with acne vulgaris. International Journal of Women's Dermatology. https://doi.org/10.1016/j.ijwd.2019.10.007
Flores-Terry, M. Á., García-Arpa, M., Franco-Muñóz, M., & González-Ruiz, L. (2018). Facial papules in frontal Fibrosing alopecia: Good response to Isotretinoin. Actas Dermo-Sifiliográficas, 109, 831-833.
Forbat, E., Ali, F. R., & Al-Niaimi, F. (2018). Dermatological indications for the use of isotretinoin beyond acne. Journal of Dermatological Treatment, 29(7), 698-705.
Gallagher, C. G., Kirthi, S. K., Cotter, C. C., Revuz, J. R., & Tobin, A. M. T. (2019). Could isotretinoin flare hidradenitis suppurativa? A case series. Clinical and Experimental Dermatology, 44(7), 777-780.
Gaufin, M., Hess, R., Hopkins, Z. H., Biber, J. E., & Secrest, A. M. (2019). Practical screening for depression in dermatology: Using technology to improve care. The British Journal of Dermatology. https://doi.org/10.1111/bjd.18514
Geissler, S. E., Michelsen, S., & Plewig, G. (2003). Very low-dose isotretinoin is effective in controlling seborrhea. Journal der Deutschen Dermatologischen Gesellschaft, 1, 952-958.
Georgala, S., Katoulis, A. C., Georgala, C., Bozi, E., & Mortakis, A. (2004). Oral isotretinoin in the treatment of recalcitrant condylomata acuminata of the cervix: A randomised placebo controlled trial. Sexually Transmitted Infections, 80, 216-218.
Ghiasi, M., Mortazavi, H., & Jafari, M. (2018). Efficacy of folic acid and vitamin B12 replacement therapies in the reduction of adverse effects of isotretinoin: A randomized controlled trial. Skinmed, 16, 239-245.
Gollnick, H., Blume-Peytavi, U., Szabó, E. L., Meyer, K. G., Hauptmann, P., Popp, G., … von der Weth, R. (2010). Systemic isotretinoin in the treatment of rosacea-Doxycycline- and placebo-controlled, randomized clinical study. Journal der Deutschen Dermatologischen Gesellschaft, 8(7), 505-515.
Guruvayoorappan, C., & Kuttan, G. (2008). 13 Cis-retinoic acid regulates cytokine production and inhibits angiogenesis by disrupting endothelial cell migration and tube formation. Journal of Experimental Therapeutics & Oncology, 7, 173-182.
Hasibur, M. R., & Meraj, Z. (2013). Combination of low-dose isotretinoin and pulsed oral azithromycin for maximizing efficacy of acne treatment. Mymensingh Medical Journal, 22, 42-48.
Healy, D., Le Noury, J., & Mangin, D. (2018). Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. The International Journal of Risk & Safety in Medicine, 29(3-4), 125-134.
Heppt, M. V., Kirchberger, M. C., Ruzicka, T., Berking, C., & Heppt, W. J. (2018). Indications and use of Isotretinoin in facial plastic surgery. Facial Plastic Surgery, 34, 75-81.
Hernandez-Perez, E., Khawaja, H. A., & Alvarez, T. Y. (2000). Oral isotretinoin as part of the treatment of cutaneous aging. Dermatologic Surgery, 26(7), 649-652.
Herold, M., Nielson, C., & Longo, M. I. (2019). Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients. Dermatologic Therapy, 32, e12803.
Huang, C. M., & Kirchhof, M. G. (2017). A new perspective on Isotretinoin treatment of hidradenitis suppurativa: A retrospective chart review of patient outcomes. Dermatology, 233(2-3), 120-125.
Ianhez, M., Pinto , S. A., Bagatin, E., & Miot , H. A. (2019). Response to the correspondence: A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization. International Journal of Dermatology 2019 Oct;58(10):e186-e187.
Ianhez, M., Pinto, S. A., Miot, H. A., & Bagatin, E. (2019). A randomized, open, controlled trial of tretinoin 0.05% cream vs. low-dose oral isotretinoin for the treatment of field cancerization. International Journal of Dermatology, 58(3), 365-373. https://doi.org/10.1111/ijd.14363
Jung, Y. S., Kim, G. M., & Bae, J. M. (2017). An adolescent with desquamation of both feet. JAMA Pediatrics, 172, 489-490.
Kaur, G. J., Brar, B. K., Kumar, S., Brar, S. K., & Singh, B. (2017). Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: A randomized open trial. International Journal of Dermatology, 56, 1352-1358.
Kaushik, A., Handa, S., Chatterjee, D., Vinay, K., & Mahajan, R. (2018). Disseminated filiform hyperkeratosis-A variant of porokeratosis? Journal of the European Academy of Dermatology and Venereology, 32, e419-e421.
Kim, Y. J., Lee, D. Y., Lee, J. Y., & Yoon, T. Y. (2012). Progressive macular hypomelanosis showing excellent response to oral isotretinoin. The Journal of Dermatology, 39, 937-938.
Koh, Y. P., Tian, E. A., & Oon, H. H. (2019). New changes in pregnancy and lactation labelling: Review of dermatologic drugs. International Journal of Women's Dermatology, 5(4), 216-226.
Kovács D, Hegyi K, Szegedi A, Deák D, Póliska S, Rühl R, Zouboulis CC5, Törőcsik D1.2019. Isotretinoin is indirectly effective in sebocytes. The British Journal of Dermatology: https://doi.org/10.1111/bjd.18562.
Krishnan, A., & Kar, S. (2012). Photoletter to the editor: Hyperkeratosis lenticularis perstans (Flegel's disease) with unusualclinical presentation. Response to isotretinoin therapy. Journal of Dermatologic Case Reports, 6, 93-95.
Kwon, H. H., Jung, J. Y., Lee, W. Y., Bae, Y., & Park, G. H. (2019). Combined treatment of recalcitrant papulopustular rosacea involving pulsed dye laser and fractional microneedling radiofrequency with low-dose isotretinoin. Journal of Cosmetic Dermatology, 19(1), 105-111. https://doi.org/10.1111/jocd.12982
Lam, M. W., Veitch, D., Barbieri, A., & Woo, P. N. (2019). Orofacial granulomatosis presenting with the unusual sign of lymphangiectasia successfully treated with isotretinoin. International Journal of Dermatology. https://doi.org/10.1111/ijd.14738
Lipozenčić J, Hadžavdić SL.2013. Perioral dermatitis. Clinics in Dermatology 2014;32(1):125-30.
London, N. J. S., Kaiser, R. S., Khan, M. A., Alshareef, R. A., Khuthaila, M., Shahlaee, A., … Regillo, C. D. (2018). Determining the effect of low-dose isotretinoin on proliferative vitreoretinopathy: The DELIVER trial. The British Journal of Ophthalmology, 103(9), 1306-1313. https://doi.org/10.1136/bjophthalmol-2018-312839
Marasca, C., Donnarumma, M., Annunziata, M. C., & Fabbrocini, G. (2019). Comment on "the effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne": May retinoids be useful to treat hyperhomocysteinemia found in patients affected by hidradenitis suppurativa? Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.16039
Marquis, K., Christensen, L. C., & Rajpara, A. (2017). Dissecting cellulitis of the scalp with excellent response to isotretinoin. Pediatric Dermatology, 34, e210-e211.
Marson, J. W., & Baldwin, H. E. (2019). The creatine kinase conundrum: A reappraisal of the association of isotretinoin, creatine kinase, and rhabdomyolysis. International Journal of Dermatology, 59(3), 279-283. https://doi.org/10.1111/ijd.14758
Maurelli, M., Gisondi, P., & Girolomoni, G. (2018). Kyrle's disease effectively treated with oral isotretinoin. The Journal of Dermatological Treatment, 29, 630-632.
Miljkovic, J. (2012). A novel therapeutic approach to plane warts: A report on two cases. Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 21, 63-64.
Mirnezami, M., & Rahimi, H. (2018). Is oral omega-3 effective in reducing mucocutaneous side effects of isotretinoin in patients with acne vulgaris? Dermatology Research and Practice, 29, 6974045.
Miziołek, B., Bergler-Czop, B., Stańkowska, A., & Brzezińska-Wcisło, L. (2019). The safety of isotretinoin treatment in patients with bone fractures. Postȩpy Dermatologii i Alergologii, 36, 18-24.
Muthu, S. K., Narang, T., Saikia, U. N., Kanwar, A. J., Parsad, D., & Dogra, S. (2016). Low-dose oral isotretinoin therapy in lichen planus pigmentosus: An open-label non-randomized prospective pilot study. International Journal of Dermatology, 55, 1048-1054.
Namazi, N., Niknezhad, N., Niknejad, N., & Asadi-Kani, Z. (2018). Familial facial lichen planopilaris and satisfactory response to isotretinoin. Dermatologic Therapy, 31, e12633.
Nico, M. M. S., & Fernandes, J. D. (2017). Low-dose isotretinoin prevents digital amputation in loricrin keratoderma (Vohwinkel syndrome with ichthyosis). Journal der Deutschen Dermatologischen Gesellschaft, 15, 665-667.
Noh, S., Shin, J. U., Jung, J. Y., & Lee, J. H. (2014). A case of sebaceous hyperplasia maintained on low-dose isotretinoin after carbon dioxide laser treatment. International Journal of Dermatology, 53, e151-e153.
Öktem, A., Hayran, Y., Arı, E., & Yalçın, B. (2019). Minimize the regular laboratory monitoring during the systemic isotretinoin treatment: Data of 704 patients with acne vulgaris. The Journal of Dermatological Treatment, 30(8), 813-817.
Olvera-Cortés, V., & Pulido-Díaz, N. (2019). Effective treatment of Morbihan's disease with long-term Isotretinoin: A report of three cases. The Journal of Clinical and Aesthetic Dermatology, 12, 32-34.
Orfanos, C. E., & Zouboulis, C. C. (1998). Oral retinoids in the treatment of seborrhoea and acne. Dermatology, 196, 140-147.
Patel, N., SA, M. K., Harview, C. L., Truong, A. K., Shi, V. Y., Chen, L., … Hsiao, J. L. (2019). Isotretinoin in the treatment of hidradenitis suppurativa: A retrospective study. The Journal of Dermatological Treatment, 26, 1-3. https://doi.org/10.1080/09546634.2019.1670779
Pedrosa, A. F., Duarte, A. F., Haneke, E., & Correia, O. (2017). Yellow facial papules associated with frontal fibrosing alopecia: A distinct histologic pattern and response to isotretinoin. Journal of the American Academy of Dermatology, 77, 764-766.
Pérez-Crespo, M., Bañuls, J., Mataix, J., & Lucas, A. (2008). Low-dose isotretinoin for treatment of chronic discoid lupus in women of childbearing age. Actas Dermo-Sifiliográficas, 99, 498-499.
Pirrone, J., Broyer, J., Otte, N., Reich, K., & Boer-Auer, A. (2017). Extensive hyperpigmentation of the face in a Filipina. Journal der Deutschen Dermatologischen Gesellschaft, 15, 1167-1168.
Poli, F., & Revuz, J. (2019). Acne flare on isotretinoin: A pointer to diagnosis of hidradenitis suppurativa. Annales de Dermatologie et de Vénéréologie, 146, 4-8.
Pona, A., Cardenas-de la Garza, J. A., Haidari, W., Cline, A., Feldman, S. R., & Taylor, S. L. (2019). Abnormal liver function tests in acne patients receiving isotretinoin. The Journal of Dermatological Treatment, 9, 1-4. https://doi.org/10.1080/09546634.2019.1662882
Prather, H. B., Alam, M., Poon, E., Arndt, K. A., & Dover, J. S. (2017). Laser safety in isotretinoin use: A survey of expert opinion and practice. Dermatologic Surgery, 43, 357-363.
Rademaker, M. (2010). Adverse effects of isotretinoin. A retrospective study of 1743 patients. The Australasian Journal of Dermatology, 51, 248-253.
Rademaker, M. (2013). Isotretinoin: Dose, duration and relapse. What does 30 years of usage tell us? The Australasian Journal of Dermatology, 54, 157-162.
Rademaker, M. (2016). Making sense of the effects of the cumulative dose of isotretinoin in acne vulgaris. International Journal of Dermatology, 55, 518-523.
Rademaker, M. (2018). Very low-dose isotretinoin in mild to moderate papulopustular rosacea; a retrospective review of 52 patients. The Australasian Journal of Dermatology, 59, 26-30.
Rallis, E., Papatheodorou, G., Bimpakis, E., Butanska, D., Menounos, P., & Papadakis, P. (2008). Systemic low-dose isotretinoin maintains remission status in epidermodysplasia verruciformis. Journal of the European Academy of Dermatology and Venereology, 22, 523-525.
Rasi, A., Behrangi, E., Rohaninasab, M., & Nahad, Z. M. (2014). Efficacy of fixed daily 20 mg of isotretinoin in moderate to severe scar prone acne. Advanced Biomedical Research, 3, 103.
Rodriguez-Garijo, N., Querol-Cisneros, E., Tomas-Velazquez, A., Estenaga, A., Moreno-Artero, E., Idoate, M. A., … España, A. (2019). Recalcitrant granulomatous periorificial dermatitis with good response to low-dose oral isotretinoin. Pediatric Dermatology, 36(6), 980-981. https://doi.org/10.1111/pde.13969
Saraswathy, K. N., Ansari, S. N., Kaur, G., Joshi, P. C., & Chandel, S. (2019). Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India. Clinical Nutrition ESPEN, 30, 199-203.
Sarkar, T., Sarkar, S., & Patra, A. (2018). Low-dose isotretinoin therapy and blood lipid abnormality: A case series with sixty patients. Journal of Family Medicine and Primary Care, 7, 171-174.
Saylam Kurtipek, G., Sarı, N., & Tuncez, A. F. (2019). Significant reduction in bilirubin levels in a patient with Gilbert syndromeunder isotretinoin treatment for acne vulgaris: A new area of use for isotretinoin? Dermatologic Therapy, 33(1), e12884. https://doi.org/10.1111/dth.12884
Saylam Kurtipek, G., Ulutas Demirbas, G., Demirbas, A., Sarı, N., Zekey, E., Tuncez Akyurek, F., & Güngör, G. (2019). The effects of isotretinoin therapy on the biliary system. Dermatologic Therapy, 26, e13177. https://doi.org/10.1111/dth.13177
Sbidian, E., Vicaut, É., Chidiack, H., Anselin, E., Cribier, B., Dréno, B., & Chosidow, O. (2016). A randomized-controlled trial of oral low-dose isotretinoin for difficult-to-treat papulopustular rosacea. The Journal of Investigative Dermatology, 136, 1124-1129.
Schaarschmidt, M. L., Schlich, M., Staub, J., Schmieder, A., Goerdt, S., & Peitsch, W. K. (2017). Lupus miliaris disseminatus faciei: Not only a facial dermatosis. Acta Dermato-Venereologica, 97, 655-656.
Singh, N., & Thappa, D. M. (2010). Erythrokeratoderma variabilis responding to low-dose isotretinoin. Pediatric Dermatology, 27, 111-113.
Spring, L. K., Krakowski, A. C., Alam, M., Bhatia, A., Brauer, J., Cohen, J., … Zaenglein, A. L. (2017). Isotretinoin and timing of procedural interventions: A systematic review with consensus recommendations. JAMA Dermatology, 153(8), 802-809.
Taverner, T., Crowe, F. L., Thomas, G. N., Gokhale, K., Thayakaran, R., Nirantharakumar, K., & Rajabally, Y. A. (2019). Circulating Folate concentrations and risk of peripheral neuropathy and mortality: A retrospective cohort study in the U.K. Nutrients, 11(10). https://doi.org/10.3390/nu11102443
Thomazini, B. F., Lamas, C. A., & Dolder, M. A. H. (2019). Safety of isotretinoin treatment as measured by liver parameters. Histology and Histopathology, 34, 755-763.
Tkachenko, E., Singer, S., Sharma, P., Barbieri, J., & Mostaghimi, A. (2019). US Food and Drug Administration reports of pregnancy and pregnancy-related adverse events associated with isotretinoin. JAMA Dermatology. https://doi.org/10.1001/jamadermatol.2019.1388
Tsai, T. Y., Hsieh, T. S., Yang, T. H., Wang, H. H., Lin, R. L., & Huang, Y. C. (2019). The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne: A meta-analysis and meta-regression. Journal of the European Academy of Dermatology and Venereology, 34(1), e32-e34. https://doi.org/10.1111/jdv.15886
Ungarelli, L. F., Hetem, C. M., & Farina Junior, J. A. (2016). Is it safe to operate on patients taking isotretinoin? Aesthetic Plastic Surgery, 40, 139-148.
Van, T. L. T., Minh, P. N., Thuy, P. T. T., Gandolfi, M., Satolli, F., Feliciani, C., … Lotti, T. (2019). Efficacy of oral low-dose isotretinoin in the treatment of acne vulgaris in Vietnam. Open Access Macedonian Journal of Medical Sciences, 7, 279-282.
Vasicek B, Adams W, Steadman L, Reserva J, Swan J.2019. Coprescription of Isotretinoin and systemic corticosteroids for acne: An analysis of the national ambulatory medical care survey. Journal of Clinical and Aesthetic Dermatology Jun;12(6):27-28.
Verma, G., Sardana, K., & Gautam, R. K. (2017). Mutilating keratoderma with concomitant alopecia and keratoses follicularis spinulosa decalvans: X-linked Olmsted syndrome and its response to Isotretinoin. Indian Dermatology Online Journal, 8, 482-484.
Wang, F., Zhao, Y. K., Wang, Z., Liu, J. H., & Luo, D. Q. (2016). Erythema dyschromicum perstans response to isotretinoin. JAMA Dermatology, 152, 841-842.
Westerhof, W., Relyveld, G. N., Kingswijk, M. M., de Man, P., & Menke, H. E. (2004). Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. Archives of Dermatology, 140, 210-214.
Xia, J., Hu, G., Hu, D., Geng, S., & Zeng, W. (2018). Concomitant use of 1,550-nm nonablative fractional laser with low-dose Isotretinoin for the treatment of acne vulgaris in Asian patients: A randomized Split-face controlled study. Dermatologic Surgery, 44, 1201-1208.
Yang, T. H., Lee, T. H., & Huang, Y. C. (2019). Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysis. Indian Journal of Dermatology, Venereology and Leprology, 85, 569-577.
Yap, F. B. (2017). Safety and efficacy of fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia. Journal of Cosmetic Dermatology, 16, 348-352.
Yazici, S., Baskan, E. B., & Saricaoglu, H. (2018). Long-term remission of recurren pityriasis versicolor with short-term systemic isotretinoin therapy. Journal of Dermatology and Cosmetology, 2, 103-104.
Yildirim, M., Inaloz, H. S., Baysal, V., Kesici, D., & Candir, O. (2004). A case of condyloma acuminatum treated successfully with low-dose isotretinoin and interferon. International Journal of Clinical Practice, 58, 889-891.
Yoon, J. H., Park, E. J., Kwon, I. H., Kim, C. W., Lee, G. S., Hann, S. K., … Kim, K. J. (2014). Concomitant use of an infrared fractional laser with low-dose isotretinoin for the treatment of acne and acne scars. The Journal of Dermatological Treatment, 25, 142-146.
Zakhem GA, Motosko CC, Mu EW, Ho RS.2019. Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review. Journal of the American Academy of Dermatology Apr;80(4):957-969.
Zhao, S., Ci, J., Xue, J., Wang, Y., Li, X., Hao, L., … Zhao, Y. (2019). Cutibacterium acnes type II strains are associated with acne in Chinese patients. Antonie Van Leeuwenhoek. https://doi.org/10.1007/s10482-019-01344-x