Multiplexed NIR-II Probes for Lymph Node-Invaded Cancer Detection and Imaging-Guided Surgery.
Animals
Breast Neoplasms
/ diagnostic imaging
Cadmium Compounds
/ chemistry
Cell Line, Tumor
Female
Fluorescent Dyes
/ chemistry
Lead
/ chemistry
Lymphatic Metastasis
/ diagnostic imaging
Mice
Optical Imaging
/ methods
Polymers
/ chemistry
Quantum Dots
/ chemistry
Selenium Compounds
/ chemistry
Sentinel Lymph Node
/ diagnostic imaging
Spectroscopy, Near-Infrared
/ methods
Surgery, Computer-Assisted
/ methods
NIR-II fluorophores
NIR-II image-guided surgery
NIR-II imaging
multiplexed NIR-II imaging
tumor metastasis detection
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
09
11
2019
revised:
22
12
2019
pubmed:
6
2
2020
medline:
18
12
2020
entrez:
6
2
2020
Statut:
ppublish
Résumé
Tumor-lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision-making. However, concurrently visualizing metastasis and performing imaging-guided lymph node surgery is challenging. Here, a multiplexed-near-infrared-II (NIR-II) in vivo imaging system using nonoverlapping NIR-II probes with markedly suppressed photon scattering and zero-autofluorescence is reported, which enables visualization of the metastatic tumor and the tumor metastatic proximal LNs resection. A bright and tumor-seeking donor-acceptor-donor (D-A-D) dye, IR-FD, is screened for primary/metastatic tumor imaging in the NIR-IIa (1100-1300 nm) window. This optimized D-A-D dye exhibits greatly improved quantum yield of organic D-A-D fluorophores in aqueous solutions (≈6.0%) and good in vivo performance. Ultrabright PbS/CdS core/shell quantum dots (QDs) with dense polymer coating are used to visualize cancer-invaded sentinel LNs in the NIR-IIb (>1500 nm) window. Compared to clinically used indocyanine green, the QDs show superior brightness and photostability (no obvious bleaching even after continuous laser irradiation for 5 h); thus, only a picomolar dose is required for sentinel LNs detection. This combination of dual-NIR-II image-guided surgery can be performed under bright light, adding to its convenience and appeal in clinical use.
Identifiants
pubmed: 32022975
doi: 10.1002/adma.201907365
doi:
Substances chimiques
Cadmium Compounds
0
Fluorescent Dyes
0
Polymers
0
Selenium Compounds
0
lead selenide
12069-00-0
Lead
2P299V784P
cadmium selenide
A7F646JC5C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1907365Subventions
Organisme : National Science Foundation of China
ID : 21772084
Organisme : Shenzhen San-Ming Project
ID : SZSM201809085
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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