Microglia Heterogeneity in the Single-Cell Era.

Aging / metabolism Animals Brain / metabolism Homeostasis Humans Macrophages / metabolism Microglia / cytology Single-Cell Analysis
CNS CyTOF heterogeneity human macrophages microglia mouse single-cell RNA sequencing

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
04 02 2020
Historique:
received: 19 03 2019
revised: 19 10 2019
accepted: 02 01 2020
entrez: 6 2 2020
pubmed: 6 2 2020
medline: 17 3 2021
Statut: ppublish

Résumé

Microglia are resident immune cells in the central nervous system (CNS) that are capable of carrying out prominent and various functions during development and adulthood under both homeostatic and disease conditions. Although microglia are traditionally thought to be heterogeneous populations, which potentially allows them to achieve a wide range of responses to environmental changes for the maintenance of CNS homeostasis, a lack of unbiased and high-throughput methods to assess microglia heterogeneity has prevented the study of spatially and temporally distributed microglia subsets. The recent emergence of novel single-cell techniques, such as cytometry by time-of-flight mass spectrometry (CyTOF) and single-cell RNA sequencing, enabled scientists to overcome such limitations and reveal the surprising context-dependent heterogeneity of microglia. In this review, we summarize the current knowledge about the spatial, temporal, and functional diversity of microglia during development, homeostasis, and disease in mice and humans.

Identifiants

DOI: 10.1016/j.celrep.2020.01.010 PMID: 32023447
pubmed: 32023447
pii: S2211-1247(20)30019-X
doi: 10.1016/j.celrep.2020.01.010
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1271-1281

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Takahiro Masuda (T)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Roman Sankowski (R)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Ori Staszewski (O)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Marco Prinz (M)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: marco.prinz@uniklinik-freiburg.de.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Eucaryotes › Animaux › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Cellules › Névroglie › Microglie › Microglia Heterogeneity in the Single-Cell Era.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Microglia Heterogeneity in the Single-Cell Era.