Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5).
Binding Sites
Cell Nucleus
/ metabolism
HeLa Cells
Humans
Mass Spectrometry
Mitogen-Activated Protein Kinase 7
/ chemistry
Phosphorylation
Protein Binding
Protein Domains
Protein Interaction Maps
Protein Processing, Post-Translational
Protein Transport
Proteomics
/ methods
Signal Transduction
Threonine
/ metabolism
Transcription, Genetic
ERK5
MAPK
mass spectrometry
phosphorylation
proteomics
transcription
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jan 2020
31 Jan 2020
Historique:
received:
21
12
2019
revised:
23
01
2020
accepted:
29
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
18
11
2020
Statut:
epublish
Résumé
The extracellular signal-regulated protein kinase 5 (ERK5) is a non-redundant mitogen-activated protein kinase (MAPK) that exhibits a unique C-terminal extension which comprises distinct structural and functional properties. Here
Identifiants
pubmed: 32023819
pii: ijms21030929
doi: 10.3390/ijms21030929
pmc: PMC7037328
pii:
doi:
Substances chimiques
Threonine
2ZD004190S
MAPK7 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 7
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Worldwide Cancer Research
ID : 15-1283
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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