GP130 Cytokines in Breast Cancer and Bone.
bone metastasis
breast cancer
cancer stem cells (CSC)
ciliary neurotrophic factor (CNTF)
glycoprotein 130 (gp130)
interleukin-6 (IL-6)
leukemia inhibitory factor (LIF)
oncostatin M (OSM)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 Jan 2020
31 Jan 2020
Historique:
received:
14
12
2019
revised:
24
01
2020
accepted:
29
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
7
2
2020
Statut:
epublish
Résumé
Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways. For example, these signals can promote the survival and dormancy of bone-disseminated cancer cells or stimulate proliferation. The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), among others. These cytokines are known to have overlapping pleiotropic functions in different cell types and are important for cross-talk between bone-resident cells. IL-6 cytokines have also been implicated in the progression and metastasis of breast, prostate, lung, and cervical cancer, highlighting the importance of these cytokines in the tumor-bone microenvironment. This review will describe the role of these cytokines in skeletal remodeling and cancer progression both within and outside of the bone microenvironment.
Identifiants
pubmed: 32023849
pii: cancers12020326
doi: 10.3390/cancers12020326
pmc: PMC7072680
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R00 CA194198
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01AR073773
Pays : United States
Organisme : NCI NIH HHS
ID : R00CA194198
Pays : United States
Organisme : U.S. Department of Defense
ID : W81XWH-18-1-0029
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