Treatment with Beta-Blockers and ACE-Inhibitors in Breast Cancer Patients Receiving Adjuvant Trastuzumab-Based Therapy and Developing Mild Cardiac Toxicity: A Prospective Study.

ACE inhibitors beta blockers breast cancer cardiac toxicity carvedilol enalapril trastuzumab

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
31 Jan 2020
Historique:
received: 06 11 2019
revised: 26 01 2020
accepted: 29 01 2020
entrez: 7 2 2020
pubmed: 7 2 2020
medline: 7 2 2020
Statut: epublish

Résumé

Angiotensin Converting Enzyme inhibitors (ACEis) and beta-blockers (BB) are suggested to prevent and treat trastuzumab-related cardiac toxicity. We performed a prospective clinical trial in women experiencing mild cardiac toxicity (MCT) while on adjuvant treatment with trastuzumab. MCT was defined as an asymptomatic absolute decrease in LVEF of ≥ 10 percentage units to >50%. Treatment consisted of enalapril 2.5 mg bid and carvedilol 3.75 mg bid, which were up-titrated to 10 mg bid for the enalapril and 6,25 mg bid of carvedilol. In patients receiving study drug, the primary study end-point was LVEF recovery, which was defined as a post-trastuzumab LVEF returning to no less than -5 percentage points of the baseline value. 103 patients were enrolled, 100 started trastuzumab, and 98 completed the planned treatment. Sixteen patients (16%) had MCT and received study drugs until trastuzumab completion. None of these patients achieved a post-trastuzumab LVEF recovery. Nevertheless, treated patients had significantly higher median LVEF recovery from nadir to post-trastuzumab LVEF in (8% points vs. 4% points, respectively, p = 0.004), resulting in no difference in post-treatment LVEF values compared to patients without MCT. Treatment of MCT with ACEis and BB allows faster LVEF recovery from nadir values and should be further studied in this setting.

Sections du résumé

BACKGROUND BACKGROUND
Angiotensin Converting Enzyme inhibitors (ACEis) and beta-blockers (BB) are suggested to prevent and treat trastuzumab-related cardiac toxicity. We performed a prospective clinical trial in women experiencing mild cardiac toxicity (MCT) while on adjuvant treatment with trastuzumab.
METHODS METHODS
MCT was defined as an asymptomatic absolute decrease in LVEF of ≥ 10 percentage units to >50%. Treatment consisted of enalapril 2.5 mg bid and carvedilol 3.75 mg bid, which were up-titrated to 10 mg bid for the enalapril and 6,25 mg bid of carvedilol. In patients receiving study drug, the primary study end-point was LVEF recovery, which was defined as a post-trastuzumab LVEF returning to no less than -5 percentage points of the baseline value.
RESULTS RESULTS
103 patients were enrolled, 100 started trastuzumab, and 98 completed the planned treatment. Sixteen patients (16%) had MCT and received study drugs until trastuzumab completion. None of these patients achieved a post-trastuzumab LVEF recovery. Nevertheless, treated patients had significantly higher median LVEF recovery from nadir to post-trastuzumab LVEF in (8% points vs. 4% points, respectively, p = 0.004), resulting in no difference in post-treatment LVEF values compared to patients without MCT.
CONCLUSION CONCLUSIONS
Treatment of MCT with ACEis and BB allows faster LVEF recovery from nadir values and should be further studied in this setting.

Identifiants

pubmed: 32023877
pii: cancers12020327
doi: 10.3390/cancers12020327
pmc: PMC7072182
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2016, project code 19174
Organisme : Rete Oncologica del Piemonte e della Valle d'Aosta
ID : Cardiorete
Organisme : Ministero della Salute
ID : Ricerca Corrente

Déclaration de conflit d'intérêts

Filippo Montemurro has received speaker’s honoraria from Roche, Novartis, Eli Lilly and Pfizer, advisory board honoraria from Roche and travel grants from Roche. Danilo Galizia has received travel grants from Pfizer, BMS, Merck, Novartis and Roche and speakers' honoraria from BMS. All the other authors do not have significant conflicts of interest to disclose.

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Auteurs

Elena Geuna (E)

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Pasquale Lombardi (P)

Medical School, University of Turin, 10124 Turin, Italy.

Rossella Martinello (R)

Oncologia Medica, Ospedale Cardinal Massaia, 14100 Asti, Italy.

Davide Garino (D)

Medical School, University of Turin, 10124 Turin, Italy.

Alessandro Bonzano (A)

Cardiology Unit, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Danilo Galizia (D)

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Annamaria Nuzzo (A)

Clinical Research Office, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Paola Berchialla (P)

Dipartimento di Scienze Cliniche e Biologiche, University of Turin, 10124 Turin, Italy.

Paolo Becco (P)

Medical School, University of Turin, 10124 Turin, Italy.

Monica Mangioni (M)

Clinical Laboratory, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Lorena De Zarlo (L)

Clinical Laboratory, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Filippo Montemurro (F)

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.

Classifications MeSH