Effects of Tissue Pressure on Transgene Expression Characteristics via Renal Local Administration Routes from Ureter or Renal Artery in the Rat Kidney.
gene transfection
kidney
local administration
naked pDNA
physical methods
pressure
renal artery
renal ureter
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
01 Feb 2020
01 Feb 2020
Historique:
received:
12
12
2019
revised:
24
01
2020
accepted:
29
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
7
2
2020
Statut:
epublish
Résumé
We previously developed a renal pressure-mediated transfection method (renal pressure method) as a kidney-specific in vivo gene delivery system. However, additional information on selecting other injection routes and applicable animals remains unclear. In this study, we selected renal arterial and ureteral injections as local administration routes and evaluated the characteristics of gene delivery such as efficacy, safety, and distribution in pressured kidney of rat. Immediately after the naked pDNA injection, via renal artery or ureter, the left kidney of the rat was pressured using a pressure controlling device. Transfection efficiency of the pressured kidney was about 100-fold higher than that of the injection only group in both administration routes. The optimal pressure intensity in the rat kidney was 1.2 N/cm
Identifiants
pubmed: 32024046
pii: pharmaceutics12020114
doi: 10.3390/pharmaceutics12020114
pmc: PMC7076412
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17K19496
Organisme : Japan Society for the Promotion of Science
ID : 18J10186
Organisme : Nagai Memorial Research Scholarship from the Pharmaceutical Society of Japan
ID : N-177001
Déclaration de conflit d'intérêts
We declare the following conflict of interest: Shigeru Kawakami received a scholarship donation for the study of incompatibility of vancomycin with other clinically used drugs, from Towa Pharmaceutical Co. Ltd., Japan. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Références
Nat Med. 2013 Aug;19(8):1047-53
pubmed: 23817022
J Biol Chem. 2011 Mar 11;286(10):8655-65
pubmed: 21209102
Eur J Vasc Endovasc Surg. 2015 Oct;50(4):494-501
pubmed: 26122834
PLoS One. 2012;7(7):e41319
pubmed: 22844458
Gene Ther. 1997 May;4(5):426-31
pubmed: 9274719
J Pathol. 1976 Mar;118(3):171-82
pubmed: 1263024
J Gene Med. 2016 Nov;18(11-12):343-352
pubmed: 27794198
Sci Rep. 2017 Mar 20;7:44904
pubmed: 28317878
J Am Soc Nephrol. 2007 Jan;18(1):58-65
pubmed: 17135397
Gene Ther. 2014 Jun;21(6):618-28
pubmed: 24784447
Nephron Extra. 2011 Jan;1(1):217-23
pubmed: 22470395
Toxicol Sci. 2008 Jan;101(1):159-70
pubmed: 17934191
J Clin Invest. 1998 Apr 1;101(7):1320-5
pubmed: 9525974
Nephrol Dial Transplant. 2006 Oct;21(10):2745-53
pubmed: 16822795
Nat Neurosci. 2015 Oct;18(10):1518-29
pubmed: 26368944
Biol Pharm Bull. 2018;41(6):944-950
pubmed: 29863083
Pharmaceutics. 2019 May 22;11(5):
pubmed: 31121989
Exp Anim. 2011;60(5):481-7
pubmed: 22041285
Expert Opin Biol Ther. 2015;15(9):1337-48
pubmed: 26125492
Clin Exp Nephrol. 2019 Dec;23(12):1345-1356
pubmed: 31482255
Drug Deliv. 2017 Nov;24(1):906-917
pubmed: 28585867
Hum Gene Ther. 2002 Feb 10;13(3):455-68
pubmed: 11860712
J Drug Target. 2016;24(5):450-6
pubmed: 26390999
J Am Soc Nephrol. 2002 Oct;13(10):2464-77
pubmed: 12239235
Nat Rev Drug Discov. 2014 Oct;13(10):759-80
pubmed: 25233993
Biochem Biophys Res Commun. 2008 Aug 1;372(3):383-7
pubmed: 18445481
Gene Ther. 2005 Nov;12(21):1551-8
pubmed: 15973441
Mol Pharm. 2018 Oct 1;15(10):4481-4490
pubmed: 30179010
J Vis Exp. 2018 Jan 8;(131):
pubmed: 29364221
J Am Soc Nephrol. 2001 May;12(5):949-54
pubmed: 11316853
Int J Nanomedicine. 2018 Apr 16;13:2309-2320
pubmed: 29713163
Kidney Int. 2004 May;65(5):1551-5
pubmed: 15086890
J Drug Target. 2015 Jun;23(5):427-35
pubmed: 25673263
Biores Open Access. 2015 Feb 01;4(1):164-74
pubmed: 26309793
Nephrology (Carlton). 2008 Feb;13(1):23-6
pubmed: 18199097
PLoS One. 2013;8(2):e56220
pubmed: 23418537
Hum Gene Ther. 2009 Oct;20(10):1157-67
pubmed: 19445600
Pharm Res. 2000 Mar;17(3):306-13
pubmed: 10801219
J Vet Med Sci. 1995 Dec;57(6):997-1002
pubmed: 8720036
Int Angiol. 2011 Apr;30(2):140-9
pubmed: 21427651
Biol Pharm Bull. 2010;33(9):1627-32
pubmed: 20823586
Clin Exp Nephrol. 2006 Dec;10(4):229-35
pubmed: 17186326
Biochem Biophys Res Commun. 2018 Feb 26;497(1):19-24
pubmed: 29407172