Blueberry Juice Antioxidants Protect Osteogenic Activity against Oxidative Stress and Improve Long-Term Activation of the Mineralization Process in Human Osteoblast-Like SaOS-2 Cells: Involvement of SIRT1.

Runt-related transcription factor 2 (RUNX-2) alkaline phosphatase (ALP) blueberry juice (BJ) dietary antioxidants osteoblast osteogenic differentiation osteoporosis oxidative stress sirtuin type 1 deacetylase (SIRT1) total soluble polyphenols (TSP)

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
01 Feb 2020
Historique:
received: 17 12 2019
revised: 27 01 2020
accepted: 29 01 2020
entrez: 7 2 2020
pubmed: 7 2 2020
medline: 7 2 2020
Statut: epublish

Résumé

Diets rich in fruits and vegetables with many antioxidants can be very important in the prevention and treatment of osteoporosis. Studies show that oxidative stress, often due to lack of antioxidants, is involved in alteration of bone remodeling and reduction in bone density. This study demonstrates in human osteoblast-like SaOS-2 cells that blueberry juice (BJ), containing 7.5 or 15 μg∙mL

Identifiants

pubmed: 32024159
pii: antiox9020125
doi: 10.3390/antiox9020125
pmc: PMC7070538
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : RICATEN18 and IANTCRPP15
ID : RICATEN18 and IANTCRPP15

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Auteurs

Vladana Domazetovic (V)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Gemma Marcucci (G)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Irene Falsetti (I)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Anna Rita Bilia (AR)

Department of Chemistry "Ugo Schiff" University of Florence, Via U. Schiff, 6, 50019 Sesto Fiorentino, Italy.

Maria Teresa Vincenzini (MT)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Maria Luisa Brandi (ML)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Teresa Iantomasi (T)

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Classifications MeSH