Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study.
Breast feeding
Infant
Respiratory syncytial virus infection
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
30
04
2019
accepted:
11
11
2019
pubmed:
7
2
2020
medline:
7
2
2020
entrez:
7
2
2020
Statut:
ppublish
Résumé
Breastfeeding reportedly reduces the overall frequency of infections. Respiratory syncytial virus (RSV), the most common respiratory pathogen in infants, involves recurrent wheezing and has a pathogenic mechanism related to airway structural damage. This study aimed to investigate whether breastfeeding has a beneficial effect against RSV-induced respiratory infection compared to formula feeding among infants in Korea. We retrospectively reviewed the medical records of infants under 1 year of age who were admitted with RSV infection between January 2016 and February 2018 at the department of pediatrics of 4 hospitals. We investigated the differences in clinical parameters such as cyanosis, chest retraction, combined infection, fever duration, oxygen use, oxygen therapy duration, intensive care unit (ICU) admission, and corticosteroid treatment of exclusive breast milk feeding (BMF), artificial milk formula fed (AMF), and mixed feeding (MF) groups. Among the 411 infants included in our study, 94, 161, and 156 were included in the BMF, MF, and AMF groups, respectively. The rates of oxygen therapy were significantly different among the BMF (4.3%), MF (8.1%), and AMF (13.5 %) groups (P=0.042). The odds ratios (ORs) for oxygen therapy was significantly higher in the AMF group than in the BMF group (adjusted OR, 3.807; 95% confidence interval, 1.22-11.90; P=0.021). The ICU admission rate of the BMF group (1.1%) was lower than that of the MF (3.5%) and AMF (4.5%) groups; however, the dissimilarity was not statistically significant (P=0.338). The severity of RSV infection requiring oxygen therapy was lower in the BMF than the AMF group. This protective role of human milk on RSV infection might decrease the need for oxygen therapy suggesting less airway damage.
Sections du résumé
BACKGROUND
BACKGROUND
Breastfeeding reportedly reduces the overall frequency of infections. Respiratory syncytial virus (RSV), the most common respiratory pathogen in infants, involves recurrent wheezing and has a pathogenic mechanism related to airway structural damage.
PURPOSE
OBJECTIVE
This study aimed to investigate whether breastfeeding has a beneficial effect against RSV-induced respiratory infection compared to formula feeding among infants in Korea.
METHODS
METHODS
We retrospectively reviewed the medical records of infants under 1 year of age who were admitted with RSV infection between January 2016 and February 2018 at the department of pediatrics of 4 hospitals. We investigated the differences in clinical parameters such as cyanosis, chest retraction, combined infection, fever duration, oxygen use, oxygen therapy duration, intensive care unit (ICU) admission, and corticosteroid treatment of exclusive breast milk feeding (BMF), artificial milk formula fed (AMF), and mixed feeding (MF) groups.
RESULTS
RESULTS
Among the 411 infants included in our study, 94, 161, and 156 were included in the BMF, MF, and AMF groups, respectively. The rates of oxygen therapy were significantly different among the BMF (4.3%), MF (8.1%), and AMF (13.5 %) groups (P=0.042). The odds ratios (ORs) for oxygen therapy was significantly higher in the AMF group than in the BMF group (adjusted OR, 3.807; 95% confidence interval, 1.22-11.90; P=0.021). The ICU admission rate of the BMF group (1.1%) was lower than that of the MF (3.5%) and AMF (4.5%) groups; however, the dissimilarity was not statistically significant (P=0.338).
CONCLUSION
CONCLUSIONS
The severity of RSV infection requiring oxygen therapy was lower in the BMF than the AMF group. This protective role of human milk on RSV infection might decrease the need for oxygen therapy suggesting less airway damage.
Identifiants
pubmed: 32024328
pii: kjp.2019.00402
doi: 10.3345/kjp.2019.00402
pmc: PMC7170789
doi:
Types de publication
Journal Article
Langues
eng
Pagination
135-140Subventions
Organisme : Korean Society of Breastfeeding Medicine
Références
Am J Respir Crit Care Med. 2017 Jul 1;196(1):29-38
pubmed: 28152315
Pediatrics. 2012 Mar;129(3):e827-41
pubmed: 22371471
J Med Virol. 1987 Jan;21(1):7-14
pubmed: 3794673
J Clin Invest. 1997 May 1;99(9):2183-91
pubmed: 9151790
Pediatr Int. 2009 Dec;51(6):812-6
pubmed: 19419530
Evid Rep Technol Assess (Full Rep). 2007 Apr;(153):1-186
pubmed: 17764214
Nutrition. 2000 Jul-Aug;16(7-8):509-11
pubmed: 10906538
Pediatrics. 2014 Nov;134(5):e1474-502
pubmed: 25349312
Eur J Immunol. 1997 Dec;27(12):3341-9
pubmed: 9464822
Allergol Immunopathol (Madr). 2011 Jan-Feb;39(1):3-9
pubmed: 20685025
Eur Cytokine Netw. 2005 Sep;16(3):206-10
pubmed: 16266861
Respir Med. 2002 Apr;96 Suppl B:S1-7
pubmed: 11996399
Children (Basel). 2015 Jul 07;2(3):289-304
pubmed: 27417364
Ther Adv Infect Dis. 2013 Aug;1(4):139-50
pubmed: 25165549
Pediatr Allergy Immunol. 2005 Aug;16(5):386-92
pubmed: 16101930
PLoS One. 2014 Feb 26;9(2):e89186
pubmed: 24586581
J Matern Fetal Neonatal Med. 2015 Jul;28(10):1133-41
pubmed: 25048748
J Korean Med Sci. 2013 Nov;28(11):1573-80
pubmed: 24265518
Lancet. 1999 Aug 14;354(9178):541-5
pubmed: 10470697
J Pediatr Pharmacol Ther. 2009 Apr;14(2):75-85
pubmed: 23055894
Front Immunol. 2017 May 29;8:584
pubmed: 28611768
Thorax. 2010 Dec;65(12):1045-52
pubmed: 20581410