Evaluation of Serum Cryptococcal Antigen Testing Using Two Novel Semiquantitative Lateral Flow Assays in Persons with Cryptococcal Antigenemia.
CrAg
CrAg positive
Cryptococcus
Cryptococcus neoformans
HIV
cryptococcal antigen
cryptococcal antigenemia
cryptococcal meningitis
human immunodeficiency virus
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
25 03 2020
25 03 2020
Historique:
received:
18
12
2019
accepted:
03
02
2020
pubmed:
7
2
2020
medline:
24
6
2021
entrez:
7
2
2020
Statut:
epublish
Résumé
Early cryptococcal disease can be detected via circulating antigen in blood before fulminant meningitis develops, when early antifungal therapy improves survival. Two semiquantitative cryptococcal antigen (CrAg) lateral flow assays (LFAs) have been developed, but their diagnostic performance has not been defined. Cryopreserved serum samples from HIV-infected Ugandans obtained as part of a prospective CrAg-screening cohort were tested in duplicate for CrAg by the CrAgSQ (IMMY) and CryptoPS (Biosynex) lateral flow assays. Case-controlled diagnostic performance was measured using the FDA-approved CrAg LFA (IMMY) as a reference standard via McNemar's test. Of 99 serum samples tested, 57 were CrAg positive (CrAg
Identifiants
pubmed: 32024729
pii: JCM.02046-19
doi: 10.1128/JCM.02046-19
pmc: PMC7098738
pii:
doi:
Substances chimiques
Antigens, Fungal
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : U01 AI089244
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086312
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI138851
Pays : United States
Organisme : FIC NIH HHS
ID : K01 TW010268
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055433
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009345
Pays : United States
Organisme : FIC NIH HHS
ID : R25 TW009345
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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