Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.

Adult Antibody-Dependent Cell Cytotoxicity Autoimmune Diseases / immunology Blood Cells / metabolism Cohort Studies Fucose / metabolism Gene Expression Regulation Glycomics Glycosylation Humans Immunoglobulin G / genetics Iodide Peroxidase / immunology Linkage Disequilibrium / genetics Models, Biological Polymorphism, Single Nucleotide / genetics Polysaccharides / metabolism Thyroid Diseases / immunology

IgG Immunology antibodies antibody-dependent cell-mediated cytotoxicity (ADCC) autoimmune thyroid disease fucosylation glycoproteins glycosylation patient cohorts thyroid peroxidase antibodies (TPOAb)

Journal

Molecular & cellular proteomics : MCP

ISSN: 1535-9484

Titre abrégé: Mol Cell Proteomics

Pays: United States

ID NLM: 101125647

Informations de publication

Date de publication:
05 2020

Historique:

received: 31 10 2019

revised: 17 01 2020

pubmed: 7 2 2020

medline: 5 2 2021

entrez: 7 2 2020

Statut: ppublish

Résumé

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

Identifiants

DOI: 10.1074/mcp.RA119.001860 PMID: 32024769 PMC: PMC7196582

pubmed: 32024769

pii: S1535-9476(20)35003-9

doi: 10.1074/mcp.RA119.001860

pmc: PMC7196582

pii:

doi:

Substances chimiques

Immunoglobulin G 0

Polysaccharides 0

Fucose 28RYY2IV3F

Iodide Peroxidase EC 1.11.1.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't Twin Study

Langues

eng

Sous-ensembles de citation

Pagination

774-792

Subventions

Organisme : Wellcome Trust

Pays : United Kingdom

Informations de copyright

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