Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
received:
05
02
2019
revised:
03
10
2019
accepted:
02
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Osteoclasts actively remodel both the mineral and proteinaceous components of bone during normal growth and development as well as pathologic states ranging from osteoporosis to bone metastasis. The cysteine proteinase cathepsin K confers osteoclasts with potent type I collagenolytic activity; however, cathepsin K-null mice, as well as cathepsin K-mutant humans, continue to remodel bone and degrade collagen by as-yet-undefined effectors. Here, we identify a cathepsin K-independent collagenolytic system in osteoclasts that is composed of a functionally redundant network of the secreted matrix metalloproteinase MMP9 and the membrane-anchored matrix metalloproteinase MMP14. Unexpectedly, whereas deleting either of the proteinases individually leaves bone resorption intact, dual targeting of
Identifiants
pubmed: 32024800
pii: 12/529/eaaw6143
doi: 10.1126/scitranslmed.aaw6143
pmc: PMC7603424
mid: NIHMS1635140
pii:
doi:
Substances chimiques
Cathepsins
EC 3.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR069620
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075168
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA071699
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA093900
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105068
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Nat Cell Biol. 2019 Apr;21(4):430-441
pubmed: 30936475
Nat Rev Immunol. 2007 Apr;7(4):292-304
pubmed: 17380158
FASEB J. 1999 Jul;13(10):1219-30
pubmed: 10385612
Mol Biol Cell. 2006 Nov;17(11):4812-26
pubmed: 16971509
Nat Commun. 2014 Jun 25;5:4255
pubmed: 24963846
J Cell Physiol. 2009 Aug;220(2):332-40
pubmed: 19360717
Dev Cell. 2008 Jun;14(6):914-25
pubmed: 18539119
Blood. 2012 Jun 7;119(23):5405-16
pubmed: 22544701
Nature. 2003 May 15;423(6937):337-42
pubmed: 12748652
J Biol Chem. 1997 Jan 24;272(4):2446-51
pubmed: 8999957
Genes Dev. 2012 Feb 15;26(4):395-413
pubmed: 22345520
Bone. 2011 Oct;49(4):623-35
pubmed: 21718816
Biol Chem. 2013 Sep;394(9):1163-79
pubmed: 23629523
J Pharmacol Sci. 2003 Apr;91(4):285-94
pubmed: 12719657
EMBO J. 2011 Jun 1;30(11):2281-93
pubmed: 21572390
Expert Opin Drug Discov. 2016;11(5):457-72
pubmed: 27001692
J Bone Miner Res. 2017 Jul;32(7):1432-1441
pubmed: 28322464
Lancet Diabetes Endocrinol. 2017 Nov;5(11):898-907
pubmed: 28689769
J Natl Cancer Inst. 2015 Feb 20;107(4):
pubmed: 25710962
J Bone Miner Res. 2013 Jan;28(1):2-17
pubmed: 23197339
J Cell Biol. 2007 Mar 12;176(6):877-88
pubmed: 17353363
Endocr Rev. 2017 Aug 1;38(4):325-350
pubmed: 28651365
Curr Biol. 2012 Jun 19;22(12):1047-56
pubmed: 22578418
Histochem J. 1996 Apr;28(4):229-45
pubmed: 8762055
Biostatistics. 2003 Apr;4(2):249-64
pubmed: 12925520
J Bone Miner Res. 2011 Jun;26(6):1252-60
pubmed: 21611966
Cancer Res. 2009 Feb 15;69(4):1517-26
pubmed: 19208838
J Exp Med. 2005 Sep 5;202(5):663-71
pubmed: 16147977
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2556-E2565
pubmed: 29463701
Mol Cell Biol. 2007 Sep;27(18):6309-22
pubmed: 17620416
J Cell Biol. 2004 Nov 22;167(4):769-81
pubmed: 15557125
J Clin Invest. 2013 Feb;123(2):666-81
pubmed: 23321671
Nat Med. 2014 Nov;20(11):1270-8
pubmed: 25282358
Nat Med. 2009 Jul;15(7):757-65
pubmed: 19584867
Nat Med. 2007 Jul;13(7):791-801
pubmed: 17618270
Nature. 2018 Oct;562(7726):223-228
pubmed: 30258231
Science. 1997 Apr 11;276(5310):270-3
pubmed: 9092479
Dev Cell. 2010 Jan 19;18(1):77-89
pubmed: 20152179
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
J Bone Miner Res. 2006 Sep;21(9):1399-408
pubmed: 16939398
Lab Invest. 1995 Mar;72(3):311-22
pubmed: 7898050
Nat Rev Immunol. 2014 Jun;14(6):392-404
pubmed: 24854589
J Bone Miner Res. 2018 Jun;33(6):1114-1125
pubmed: 29521005
Bone. 2000 Oct;27(4):529-33
pubmed: 11033448
J Bone Miner Res. 1999 Nov;14(11):1902-8
pubmed: 10571690
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Jun;29(3):309-13
pubmed: 22678797
Curr Osteoporos Rep. 2018 Aug;16(4):466-477
pubmed: 29934753
Nat Rev Genet. 2003 Aug;4(8):638-49
pubmed: 12897775
Dev Cell. 2012 Jun 12;22(6):1176-90
pubmed: 22632802
J Bone Miner Res. 2003 May;18(5):859-67
pubmed: 12733725
Genome Res. 1996 Nov;6(11):1050-5
pubmed: 8938428
Cancer Sci. 2017 Jun;108(6):1095-1100
pubmed: 28267240
Bonekey Rep. 2014 Jan 08;3:481
pubmed: 24466412
Nat Commun. 2018 Oct 5;9(1):4108
pubmed: 30291236
J Bone Miner Res. 2006 Jan;21(1):58-66
pubmed: 16355274
Rheumatology (Oxford). 2016 Dec;55(suppl 2):ii61-ii63
pubmed: 27856662
Cell. 1998 May 1;93(3):411-22
pubmed: 9590175
J Biol Chem. 1998 Nov 27;273(48):32347-52
pubmed: 9822715
Calcif Tissue Int. 2003 Oct;73(4):380-6
pubmed: 12874701
Bone. 2015 Feb;71:115-23
pubmed: 25445450
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
pubmed: 10737763
Endocrinology. 2001 Dec;142(12):5371-8
pubmed: 11713237
J Bone Miner Res. 2002 Jan;17(1):77-90
pubmed: 11771672
Nat Cell Biol. 2016 Sep;18(9):917-29
pubmed: 27479603
J Biol Chem. 2007 Sep 14;282(37):27037-45
pubmed: 17623673
Dev Cell. 2018 Oct 22;47(2):145-160.e6
pubmed: 30269950
J Bone Miner Res. 1999 Oct;14(10):1649-53
pubmed: 10491211
Nat Med. 2016 Nov 8;22(11):1203-1205
pubmed: 27824823
PLoS One. 2015 May 11;10(5):e0127063
pubmed: 25961845
J Clin Invest. 2008 Sep;118(9):3012-24
pubmed: 18677407
Dev Cell. 2013 May 28;25(4):402-16
pubmed: 23685250
J Cell Biol. 2000 Nov 13;151(4):879-89
pubmed: 11076971
Nature. 2013 Apr 25;496(7446):445-55
pubmed: 23619691
Lancet. 2011 Apr 9;377(9773):1276-87
pubmed: 21450337
Cell. 1999 Oct 1;99(1):81-92
pubmed: 10520996
EMBO J. 2015 Jul 14;34(14):1875-88
pubmed: 25991604
Genes Dev. 2016 Jan 15;30(2):208-19
pubmed: 26744418
Bone. 2004 Nov;35(5):1107-19
pubmed: 15542036
J Cell Sci. 2007 May 1;120(Pt 9):1607-14
pubmed: 17405818
J Biol Chem. 2006 Dec 1;281(48):36846-55
pubmed: 17018528
Chron Respir Dis. 2009;6(2):81-7
pubmed: 19411568
Nat Rev Rheumatol. 2011 Jun 14;7(8):447-56
pubmed: 21670768
Nat Commun. 2016 Mar 01;7:10824
pubmed: 26926389
Calcif Tissue Int. 1985 Jan;37(1):25-31
pubmed: 3922593
Bone. 2008 Jan;42(1):200-11
pubmed: 17962093
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13453-8
pubmed: 9811821
Prog Mol Biol Transl Sci. 2017;148:203-303
pubmed: 28662823
J Clin Invest. 1999 Feb;103(4):517-24
pubmed: 10021460
Science. 1996 Aug 30;273(5279):1236-8
pubmed: 8703060