Temporomandibular joint damage in K/BxN arthritic mice.
Animals
Arthritis, Experimental
/ immunology
Arthritis, Rheumatoid
/ immunology
Bone and Bones
/ diagnostic imaging
Disease Models, Animal
Humans
Magnetic Resonance Imaging
Matrix Metalloproteinase 8
/ immunology
Mice
Mice, Transgenic
Temporomandibular Joint
/ diagnostic imaging
Tomography, X-Ray Computed
X-Ray Microtomography
/ methods
Journal
International journal of oral science
ISSN: 2049-3169
Titre abrégé: Int J Oral Sci
Pays: India
ID NLM: 101504351
Informations de publication
Date de publication:
06 02 2020
06 02 2020
Historique:
received:
04
10
2019
accepted:
15
12
2019
revised:
13
12
2019
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
14
2
2020
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/BxN mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint (TMJ) inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging (μMRI) and micro-computed tomography (μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/BxN animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes (FLSs) isolated from the TMJ of K/BxN mice secreted inflammatory cytokines (IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases (MMPs). K/BxN mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.
Identifiants
pubmed: 32024813
doi: 10.1038/s41368-019-0072-z
pii: 10.1038/s41368-019-0072-z
pmc: PMC7002582
doi:
Substances chimiques
Matrix Metalloproteinase 8
EC 3.4.24.34
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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