Comparative Study on Pulmonary Toxicity in Mice Induced by Exposure to Unflavoured and Apple- and Strawberry-Flavoured Tobacco Waterpipe Smoke.
Animals
Caspase 3
/ metabolism
Catalase
/ metabolism
Disease Models, Animal
Flavoring Agents
/ administration & dosage
Fragaria
Humans
Interleukin-6
/ metabolism
Malus
Mice
NF-kappa B
/ metabolism
Oxidative Stress
Pneumonia
/ chemically induced
Signal Transduction
Tobacco Products
/ adverse effects
Tumor Necrosis Factor-alpha
/ metabolism
Water Pipe Smoking
/ adverse effects
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
09
2019
revised:
05
12
2019
accepted:
10
12
2019
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
22
9
2020
Statut:
epublish
Résumé
The use of flavoured tobacco products in waterpipe smoking (WPS) has increased its attractiveness and consumption. Nonetheless, the influence of flavourings on pulmonary toxicity caused by WPS remains unclear. Here, the pulmonary toxicity induced by plain (P)-WPS, apple-flavoured (AF)-WPS, and strawberry-flavoured (SF)-WPS (30 minutes/day, 5 days/week for 1 month) was investigated in mice. Control mice were exposed to air. Exposure to P-WPS or AF-WPS or SF-WPS induced a dose-dependent increase of airway hyperreactivity to methacholine. The histological evaluation of the lungs in all the WPS groups revealed the presence focal areas of dilated alveolar spaces and foci of widening of interalveolar spaces with inflammatory cells. In the lung, the activity of neutrophil elastase and myeloperoxidase and the concentrations of tumor necrosis factor-
Identifiants
pubmed: 32025277
doi: 10.1155/2020/6450450
pmc: PMC6983288
doi:
Substances chimiques
Flavoring Agents
0
Interleukin-6
0
NF-kappa B
0
Tumor Necrosis Factor-alpha
0
Catalase
EC 1.11.1.6
Caspase 3
EC 3.4.22.-
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6450450Informations de copyright
Copyright © 2020 Abderrahim Nemmar et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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