The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.
Bone enhancement
Bone healing
Bone substitutes
Cell therapy
Diamond concept
Diaphyseal fractures
Nonunions
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
23
07
2019
revised:
11
01
2020
accepted:
26
01
2020
entrez:
7
2
2020
pubmed:
7
2
2020
medline:
7
2
2020
Statut:
epublish
Résumé
Diaphyseal fractures represent a complex biological entity that could often end into impaired bone-healing, with delayed union and non-union occurring up to 10% of cases. The role of the modern orthopaedic surgeon is to optimize the fracture healing environment, recognize and eliminate possible interfering factors, and choose the best suited surgical fixation technique. The impaired reparative process after surgical intervention can be modulated with different surgical techniques, such as dynamization or exchange nailing after failed intramedullary nailing. Moreover, the mechanical stability of a nail can be improved through augmentation plating, bone grafting or external fixation techniques with satisfactory results. According to the "diamond concept", local therapies, such as osteoconductive scaffolds, bone growth factors, and osteogenic cells can be successfully applied in "polytherapy" for the enhancement of delayed union and non-union of long bones diaphyseal fractures. Moreover, systemic anti-osteoporosis anabolic drugs, such as teriparatide, have been proposed as off-label treatment for bone healing enhancement both in fresh complex shaft fractures and impaired unions, especially for fragility fractures. The article aims to review the biological and mechanical principles of failed reparative osteogenesis of diaphyseal fractures after surgical treatment. Moreover, the evidence about the modern non-surgical and pharmacological options for bone healing enhancement will discussed.
Identifiants
pubmed: 32025538
doi: 10.1016/j.bonr.2020.100249
pii: S2352-1872(20)30008-5
pii: 100249
pmc: PMC6997516
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100249Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors.
Références
Eur J Orthop Surg Traumatol. 2014 Jul;24(5):663-70
pubmed: 23756643
Eur J Orthop Surg Traumatol. 2013 Nov;23 Suppl 2:S291-4
pubmed: 23412268
Clin Cases Miner Bone Metab. 2014 May;11(2):105-9
pubmed: 25285136
Eur J Orthop Surg Traumatol. 2018 Jan;28(1):131-137
pubmed: 28766069
Injury. 2011 Nov;42(11):1353-61
pubmed: 21726859
J Orthop Traumatol. 2019 Apr 11;20(1):21
pubmed: 30976944
J Orthop Res. 2003 Mar;21(2):335-40
pubmed: 12568967
Bone Rep. 2017 Mar 16;6:87-100
pubmed: 28377988
Curr Osteoporos Rep. 2015 Oct;13(5):327-35
pubmed: 26254939
J Clin Orthop Trauma. 2018 Jul-Sep;9(3):260-268
pubmed: 30202159
Injury. 2015 Dec;46 Suppl 8:S55-64
pubmed: 26747920
Orthop Surg. 2009 Feb;1(1):17-21
pubmed: 22009776
Rheumatol Int. 2012 Feb;32(2):439-43
pubmed: 21120486
Orthopedics. 2006 Oct;29(10):939-41
pubmed: 17061421
J Bone Joint Surg Am. 1994 Jan;76(1):26-34
pubmed: 8288661
J Bone Miner Res. 2017 May;32(5):1027-1033
pubmed: 28071822
Clin Orthop Relat Res. 1990 Jul;(256):260-73
pubmed: 2364613
Clin Orthop Relat Res. 1977 May;(124):5-8
pubmed: 340088
Injury. 2009 Jun;40(6):663-8
pubmed: 19324360
Clin Orthop Relat Res. 1968 Jul-Aug;59:59-96
pubmed: 4969827
Injury. 2007 Sep;38 Suppl 4:S3-6
pubmed: 18224731
Injury. 2018 Nov;49 Suppl 3:S26-S31
pubmed: 30415666
Injury. 2008 Dec;39(12):1391-402
pubmed: 19027898
Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):209-213
pubmed: 28228784
J Orthop Res. 2011 Feb;29(2):173-80
pubmed: 20740672
Injury. 2019 Nov;50(11):1986-1991
pubmed: 31431330
J Orthop Traumatol. 2013 Mar;14(1):51-7
pubmed: 23179083
Orthop Clin North Am. 1999 Oct;30(4):571-81
pubmed: 10471762
Injury. 2016 Jun;47 Suppl 2:S21-6
pubmed: 27338222
JBJS Rev. 2017 Sep;5(9):e7
pubmed: 28953136
J Clin Orthop Trauma. 2017 Nov;8(Suppl 2):S21-S30
pubmed: 29339841
J Bone Miner Res. 2002 Mar;17(3):513-20
pubmed: 11874242
J Bone Miner Res. 2010 Feb;25(2):404-14
pubmed: 19594305
Biomed Res Int. 2018 Apr 30;2018:1809091
pubmed: 29854729
JAMA Surg. 2016 Nov 16;151(11):e162775
pubmed: 27603155
Alcohol. 2005 Jul;36(3):201-14
pubmed: 16377462
PLoS One. 2014 Jan 02;9(1):e84740
pubmed: 24392155
J Bone Joint Surg Br. 2002 Nov;84(8):1093-110
pubmed: 12463652
Aging Clin Exp Res. 2013 Oct;25 Suppl 1:S15-7
pubmed: 24046046
J Bone Joint Surg Am. 2011 May 4;93(9):801-8
pubmed: 21454742
J Bone Joint Surg Am. 2002 Dec;84(12):2123-34
pubmed: 12473698
Injury. 2013 Feb;44(2):226-31
pubmed: 23200761
Injury. 2008 Sep;39 Suppl 2:S83-90
pubmed: 18804578
Am J Sports Med. 2015 Dec;43(12):3062-70
pubmed: 26473014
J Bone Joint Surg Am. 1994 Jun;76(6):820-6
pubmed: 8200888
Arch Orthop Trauma Surg. 2011 Jan;131(1):93-9
pubmed: 20532901
Osteoporos Int. 2011 Aug;22(8):2329-36
pubmed: 21153021
J Orthop Trauma. 1999 May;13(4):252-7
pubmed: 10342350
Bone. 2014 Jul;64:288-97
pubmed: 24792958
Clin Orthop Relat Res. 1989 Feb;(239):263-85
pubmed: 2912628
J Bone Miner Res. 2002 Nov;17(11):2038-47
pubmed: 12412812
Clin Cases Miner Bone Metab. 2012 Sep;9(3):166-9
pubmed: 23289032
J Bone Joint Surg Am. 2013 Dec 4;95(23):2088-96
pubmed: 24306695
BMC Res Notes. 2014 May 27;7:317
pubmed: 24886079
J Bone Joint Surg Am. 2012 Dec 5;94(23):2113-9
pubmed: 23097066
J Bone Joint Surg Br. 2007 Feb;89(2):265-72
pubmed: 17322450
Bone. 2008 May;42(5):894-906
pubmed: 18314404
Osteoporos Int. 2016 Mar;27(3):861-871
pubmed: 26419471
J Bone Joint Surg Am. 1988 Aug;70(7):1067-81
pubmed: 3042791
J Mater Sci Mater Med. 2017 Sep;28(9):137
pubmed: 28785889
J Bone Miner Res. 2019 Sep;34(9):1690-1706
pubmed: 31081125
Orthopedics. 2016 Nov 1;39(6):e1117-e1123
pubmed: 27575039
Orthop Clin North Am. 2017 Jul;48(3):301-309
pubmed: 28577779
Orthop Clin North Am. 2017 Jul;48(3):311-321
pubmed: 28577780
Injury. 2005 Jan;36(1):203-6
pubmed: 15589942
J Bone Joint Surg Am. 2007 Jan;89(1):177-88
pubmed: 17200326
J Bone Joint Surg Am. 2011 Sep 7;93(17):1569-76
pubmed: 21915570
BMC Surg. 2019 Apr 5;19(1):35
pubmed: 30953554
PLoS One. 2015 Nov 03;10(11):e0141973
pubmed: 26529606
Injury. 2015 Dec;46 Suppl 8:S8-S19
pubmed: 26747924
Chin J Traumatol. 2017 Apr;20(2):94-98
pubmed: 28359592
Injury. 2010 Jun;41(6):563-7
pubmed: 19740464
J Arthroplasty. 2014 May;29(5):872-6
pubmed: 24650900
Acta Pharmacol Sin. 2013 Mar;34(3):387-92
pubmed: 23459092
Clin Sports Med. 2019 Jan;38(1):79-95
pubmed: 30466724
Calcif Tissue Int. 2010 Sep;87(3):193-202
pubmed: 20552333
J Orthop Trauma. 2015 Dec;29(12):569-73
pubmed: 26595595
J Bone Joint Surg Am. 2013 Jul 3;95(13):1184-92
pubmed: 23824386
Clin Cases Miner Bone Metab. 2017 May-Aug;14(2):189-196
pubmed: 29263732
Injury. 2005 Nov;36 Suppl 4:S51-9
pubmed: 16291324
Bone. 2019 Mar;120:1-8
pubmed: 30268814
J Biomech. 1999 Mar;32(3):255-66
pubmed: 10093025
Orthopedics. 1989 Jan;12(1):21-34
pubmed: 2915947
Nutrients. 2018 Oct 31;10(11):
pubmed: 30384490
Injury. 2015 Nov;46 Suppl 5:S43-6
pubmed: 26343300
Anat Rec. 1987 Sep;219(1):1-9
pubmed: 3688455
Eur J Orthop Surg Traumatol. 2019 Jan;29(1):169-173
pubmed: 29931529
Arch Orthop Trauma Surg. 2016 Feb;136(2):149-56
pubmed: 26646845
Orthop Traumatol Surg Res. 2017 Feb;103(1S):S161-S169
pubmed: 27867137
Nat Rev Rheumatol. 2009 Jul;5(7):392-9
pubmed: 19568253
Injury. 2008 Sep;39 Suppl 2:S45-57
pubmed: 18804573
Int Orthop. 2018 Feb;42(2):247-258
pubmed: 29273837
J Bone Joint Surg Br. 1995 May;77(3):407-11
pubmed: 7744925
Bone. 2005 Nov;37(5):711-9
pubmed: 16143574
Injury. 2007 Mar;38 Suppl 1:S75-80
pubmed: 17383488
Calcif Tissue Int. 2008 Jun;82(6):465-74
pubmed: 18528610
Clin Orthop Relat Res. 1999 Aug;(365):175-83
pubmed: 10627702
Bone. 2010 Jul;47(1):65-73
pubmed: 20348041
HSS J. 2015 Jul;11(2):104-11
pubmed: 26140028
J Bone Miner Res. 2010 Dec;25(12):2735-43
pubmed: 20533373
Front Physiol. 2017 Jan 24;7:678
pubmed: 28174539
Calcif Tissue Int. 2001 Sep;69(3):121-9
pubmed: 11683526
Hip Int. 2019 Jul;29(4):385-392
pubmed: 30253655
Arch Orthop Trauma Surg. 2014 Aug;134(8):1093-106
pubmed: 24895156
Injury. 2017 Jun;48(6):1217-1223
pubmed: 28302305
Bone Joint Res. 2017 Jul;6(7):423-432
pubmed: 28733366
Injury. 2006 Aug;37(8):740-50
pubmed: 16487528
Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008579
pubmed: 22336847
J Am Acad Orthop Surg. 2007 Feb;15(2):97-106
pubmed: 17277256
Int Orthop. 2019 Jan;43(1):217-222
pubmed: 30167836
Med Biol Eng Comput. 2017 Nov;55(11):1895-1914
pubmed: 28785849
Am J Orthop (Belle Mead NJ). 2005 Jul;34(7):329-32
pubmed: 16130350
Acta Orthop. 2017 Aug;88(4):434-439
pubmed: 28508682
Wien Klin Wochenschr. 2013 May;125(9-10):244-53
pubmed: 23689954
Diagnostics (Basel). 2019 Dec 29;10(1):
pubmed: 31905717
J Trauma. 1993 Feb;34(2):185-92
pubmed: 8459454
Injury. 1998;29 Suppl 3:C3-6
pubmed: 10341891
Bone. 2013 Jan;52(1):360-5
pubmed: 23072919
Arch Orthop Trauma Surg. 2016 May;136(5):631-8
pubmed: 26852379
Cochrane Database Syst Rev. 2014 Jun 23;(6):CD008579
pubmed: 24956457
Injury. 2001 Jan;32(1):61-5
pubmed: 11164405
Musculoskelet Surg. 2020 Aug;104(2):179-185
pubmed: 31183680
Biomaterials. 2006 Jun;27(17):3249-55
pubmed: 16490250
Biomed Res Int. 2016;2016:4061539
pubmed: 27022610
Hip Pelvis. 2016 Sep;28(3):148-156
pubmed: 27777917
Expert Opin Investig Drugs. 2012 Aug;21(8):1169-76
pubmed: 22694479
J Bone Joint Surg Am. 2006 Sep;88 Suppl 1 Pt 2:322-7
pubmed: 16951103
Curr Stem Cell Res Ther. 2013 May;8(3):260-8
pubmed: 23317434
BMJ Case Rep. 2020 Jan 9;13(1):
pubmed: 31924710
J Bone Miner Res. 2008 Aug;23(8):1204-16
pubmed: 18348700
Int Orthop. 2007 Feb;31(1):87-92
pubmed: 16691386
Expert Opin Drug Saf. 2012 Mar;11(2):215-20
pubmed: 22145960
J Bone Joint Surg Am. 2011 Sep 7;93(17):1583-7
pubmed: 21915572
J Bone Joint Surg Am. 2007 Jan;89(1):96-101
pubmed: 17200316
Clin Orthop Relat Res. 1989 Jan;(238):249-81
pubmed: 2910611
Bone Joint J. 2016 Jan;98-B(1):81-7
pubmed: 26733519
Injury. 2016 Jun;47(6):1309-17
pubmed: 27015752
J Bone Miner Metab. 2019 Mar;37(2):256-263
pubmed: 29721806
Curr Osteoporos Rep. 2019 Feb;17(1):36-47
pubmed: 30671884
J Orthop Trauma. 2000 Jun-Jul;14(5):335-8
pubmed: 10926240
J Bone Miner Metab. 2015 Sep;33(5):553-9
pubmed: 25227287
Hip Int. 2011 Mar-Apr;21(2):211-6
pubmed: 21462153
Eur Cell Mater. 2018 Jun 22;35:365-385
pubmed: 29931664
J Orthop Res. 1997 Jul;15(4):577-84
pubmed: 9379268
Injury. 2002 Oct;33(8):691-9
pubmed: 12213420
J Bone Miner Res. 2014 Jan;29(1):1-23
pubmed: 23712442
Musculoskelet Surg. 2015 Dec;99(3):243-8
pubmed: 26193983