The relationship between oral diseases and infectious complications in patients under dialysis.
biomarkers
dialysis
infection
periodontitis
saliva
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
31
10
2019
revised:
08
01
2020
accepted:
30
01
2020
pubmed:
7
2
2020
medline:
29
10
2020
entrez:
7
2
2020
Statut:
ppublish
Résumé
Association was investigated between oral health before dialysis and the incidence of systemic infections during dialysis. We hypothesized that low-grade systemic inflammation caused by poor oral health associates with infectious episodes in patients on dialysis, despite earlier eradication of oral infection foci. A total of 117 patients (46 with peritoneal and 71 with hemodialysis) were examined and treated at predialysis stage and followed up during dialysis. Number of infection episodes and microorganisms cultured from blood and peritoneal fluid were analyzed. Number of teeth, periodontal inflammatory burden, and total dental index scores were assessed, and salivary matrix metalloproteinase 8, triggering receptor on myeloid cells 1, peptidoglycan recognition protein 1 (PGLYRP1), and interleukin-1β were measured. In hemodialysis, 134 infection episodes were recorded, while peritoneal dialysis group had 77 peritonitis episodes. Culture-negative samples were 69% in hemodialysis and 23% in peritoneal dialysis group. Staphylococci were the most frequently associated microorganisms. Infections during dialysis did neither associate with oral health parameters nor associate with salivary inflammatory biomarkers, except for PGLYRP1, which associated with number of infection episodes during hemodialysis (p = .046). A number of infection episodes during hemodialysis were associated with salivary PGLYRP1 but not the other salivary markers or oral infection markers.
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Pagination
1045-1052Subventions
Organisme : Helsinki University Hospital
ID : TYH20012128
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
Références
Bahrani-Mougeot, F. K., Paster, B. J., Coleman, S., Ashar, J., Barbuto, S., & Lockhart, P. B. (2008). Diverse and novel oral bacterial species in blood following dental procedures. Journal of Clinical Microbiology, 46(6), 2129-2132. https://doi.org/10.1128/JCM.02004-07
Berman, S. J., Johnson, E. W., Nakatsu, C., Alkan, M., Chen, R., & LeDuc, J. (2004). Burden of infection in patients with end-stage renal disease requiring long-term dialysis. Clinical Infectious Diseases, 39(12), 1747-1753. https://doi.org/10.1086/424516
D’Amato-Palumbo, S., Kaplan, A. A., Feinn, R. S., & Lalla, R. V. (2013). Retrospective study of microorganisms associated with vascular access infections in hemodialysis patients. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 115(1), 56-61. https://doi.org/10.1016/j.oooo.2012.08.445
Deschamps-Lenhardt, S., Martin-Cabezas, R., Hannedouche, T., & Huck, O. (2019). Association between periodontitis and chronic kidney disease: Systematic review and meta-analysis. Oral Diseases, 25(2), 385-402. https://doi.org/10.1111/odi.12834
Grigoriadis, A., Sorsa, T., Räisänen, I., Pärnänen, P., Tervahartiala, T., & Sakellari, D. (2019). Prediabetes/Diabetes can be screened at the dental office by a low-cost and fast chair-side/point-of-care aMMP-8 immunotest. Diagnostics (Basel, Switzerland), 9(4), 151. https://doi.org/10.3390/diagnostics9040151
Lahdentausta, L. S. J., Paju, S., Mäntylä, P., Buhlin, K., Tervahartiala, T., Pietiäinen, M., … Pussinen, P. J. (2018). Saliva and serum biomarkers in periodontitis and coronary artery disease. Journal of Clinical Periodontology, 45(9), 1045-1055. https://doi.org/10.1111/jcpe.12976
Leppilahti, J., Harjunmaa, U., Järnstedt, J., Mangani, C., Hernández, M., Tervahartiala, T., … Sorsa, T. (2018). Diagnosis of newly delivered mothers for periodontitis with a novel oral-rinse aMMP-8 point-of-care test in a rural Malawian population. Diagnostics, 8(3), 67. https://doi.org/10.3390/diagnostics8030067
Li, P.-K.-T., Szeto, C. C., Piraino, B., de Arteaga, J., Fan, S., Figueiredo, A. E., … Johnson, D. W. (2016). ISPD peritonitis recommendations: 2016 update on prevention and treatment. Peritoneal Dialysis International, 36(5), 481-508. https://doi.org/10.3747/pdi.2016.00078
Liakopoulos, V., Nikitidou, O., Kalathas, T., Roumeliotis, S., Salmas, M., & Eleftheriadis, T. (2017). Peritoneal dialysis-related infections recommendations: 2016 update. What is new? International Urology and Nephrology, 49(12), 2177-2184. https://doi.org/10.1007/s11255-017-1632-9
Lindy, O., Suomalainen, K., Mäkelä, M., & Lindy, S. (2008). Statin use is associated with fewer periodontal lesions: A retrospective study. BMC Oral Health, 8(1), 16. https://doi.org/10.1186/1472-6831-8-16
Lockhart, P. B., Brennan, M. T., Sasser, H. C., Fox, P. C., Paster, B. J., & Bahrani-Mougeot, F. K. (2008). Bacteremia associated with toothbrushing and dental extraction. Circulation, 117(24), 3118-3125. https://doi.org/10.1161/CIRCULATIONAHA.107.758524
Lockhart, P. B., & Durack, D. T. (1999). Oral microflora as a cause of endocarditis and other distant site infections. Infectious Disease Clinics of North America, 13(4), 833-850. https://doi.org/10.1016/S0891-5520(05)70111-2
Lu, X., Wang, M., Qi, J., Wang, H., Li, X., Gupta, D., & Dziarski, R. (2006). Peptidoglycan recognition proteins are a new class of human bactericidal proteins. Journal of Biological Chemistry, 281(9), 5895-5907. https://doi.org/10.1074/jbc.M511631200
Mattila, K. J., Nieminen, M. S., Valtonen, V. V., Rasi, V. P., Kesäniemi, Y. A., Syrjälä, S. L., … Jokinen, M. J. (1989). Association between dental health and acute myocardial infarction. British medical journal, 298(6676), 779-781. https://doi.org/10.1136/bmj.298.6676.779
Meurman, J. H., & Hämäläinen, P. (2006). Oral health and morbidity - implications of oral infections on the elderly. Gerodontology, 23(1), 3-16. https://doi.org/10.1111/j.1741-2358.2006.00102.x
Neovius, M., Jacobson, S. H., Eriksson, J. K., Elinder, C. G., & Hylander, B. (2014). Mortality in chronic kidney disease and renal replacement therapy: A population-based cohort study. British Medical Journal Open, 4(2), e004251. https://doi.org/10.1136/bmjopen-2013-004251
Nessim, S. J., Bargman, J. M., & Jassal, S. V. (2010). Relationship between double-cuff versus single-cuff peritoneal dialysis catheters and risk of peritonitis. Nephrology Dialysis Transplantation, 25(7), 2310-2314. https://doi.org/10.1093/ndt/gfq002
Nylund, K. M., Meurman, J. H., Heikkinen, A. M., Furuholm, J. O., Ortiz, F., & Ruokonen, H. M. (2018). Oral health in patients with renal disease: A longitudinal study from predialysis to kidney transplantation. Clinical Oral Investigations, 22(1), 339-347. https://doi.org/10.1007/s00784-017-2118-y
Nylund, K. M., Meurman, J. H., Heikkinen, A. M., Honkanen, E., Vesterinen, M., Furuholm, J. O., … Ruokonen, H. M. (2015). Periodontal inflammatory burden and salivary matrix metalloproteinase-8 concentration among patients with chronic kidney disease at the predialysis stage. Journal of Periodontology, 86(11), 1212-1220. https://doi.org/10.1902/jop.2015.150285
Nylund, K. M., Ruokonen, H., Sorsa, T., Heikkinen, A. M., Meurman, J. H., Ortiz, F., … Bostanci, N. (2017). Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation kidney disease. Journal of Periodontology, 89(1), 1-17. https://doi.org/10.1902/jop.2017.170218
Oka, H., Yamada, S., Kamimura, T., Aihara, S., Hyodo, M., Terakado, N., … Kitazono, T. (2018). Better oral hygiene habits are associated with a lower incidence of peritoneal dialysis-related peritonitis. Therapeutic Apheresis and Dialysis, 23(2), 187-194. https://doi.org/10.1111/1744-9987.12757
Osanai, A., Sashinami, H., Asano, K., Li, S. J., Hu, D. L., & Nakane, A. (2011). Mouse peptidoglycan recognition protein PGLYRP-1 plays a role in the host innate immune response against Listeria monocytogenes infection. Infection and Immunity, 79(2), 858-866. https://doi.org/10.1128/IAI.00466-10
Patel, P. R., Kallen, A. J., & Arduino, M. J. (2010). Epidemiology, surveillance, and prevention of bloodstream infections in hemodialysis patients. American Journal of Kidney Diseases, 56(3), 566-577. https://doi.org/10.1053/J.AJKD.2010.02.352
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., … Gustafsson, A. (2013). Salivary biomarkers for detection of systemic diseases. PLoS ONE, 8(4), e61356. https://doi.org/10.1371/journal.pone.0061356
Rojas, L., Muñoz, P., Kestler, M., Arroyo, D., Guembe, M., Rodríguez-Créixems, M., … Bouza, E. (2013). Bloodstream infections in patients with kidney disease: Risk factors for poor outcome and mortality. Journal of Hospital Infection, 85(3), 196-205. https://doi.org/10.1016/J.JHIN.2013.07.009
Ruokonen, H., Nylund, K., Furuholm, J., Meurman, J. H., Sorsa, T., Kotaniemi, K., … Heikkinen, A. M. (2017). Oral health and mortality in patients with chronic kidney disease. Journal of Periodontology, 88(1), 26-33. https://doi.org/10.1902/jop.2016.160215
Scannapieco, F. A. (1998). Position paper of The American Academy of Periodontology: Periodontal disease as a potential risk factor for systemic diseases. Journal of Periodontology, 69(7), 841-850. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9706864.
Shariff, G., Brennan, M. T., Louise Kent, M., Fox, P. C., Weinrib, D., Burgess, P., & Lockhart, P. B. (2004). Relationship between oral bacteria and hemodialysis access infection. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 98(4), 418-422. https://doi.org/10.1016/j.tripleo.2004.04.026
Silbereisen, A., Hallak, A. K., Nascimento, G. G., Sorsa, T., Belibasakis, G. N., Lopez, R., & Bostanci, N. (2019). Regulation of PGLYRP1 and TREM-1 during progression and resolution of gingival inflammation. JDR Clinical and Translational Research, 4(4), 352-359. https://doi.org/10.1177/2380084419844937
Sorsa, T., Gieselmann, D., Arweiler, N. B., & Hernández, M. (2017). A quantitative point-of-care test for periodontal and dental peri-implant diseases. Nature Reviews Disease Primers, 3(1), 17069. https://doi.org/10.1038/nrdp.2017.69
Tokars, J. I., Light, P., Anderson, J., Miller, E. R., Parrish, J., Armistead, N., … Gehr, T. (2001). A prospective study of vascular access infections at seven outpatient hemodialysis centers. American Journal of Kidney Diseases, 37(6), 1232-1240. https://doi.org/10.1053/AJKD.2001.24527
Vesterinen, M., Ruokonen, H., Furuholm, J., Honkanen, E., & Meurman, J. H. (2011). Oral health in predialysis patients with emphasis on diabetic nephropathy. Clinical Oral Investigations, 15(1), 99-104. https://doi.org/10.1007/s00784-009-0360-7
Wang, M., Liu, L.-H., Wang, S., Li, X., Lu, X., Gupta, D., & Dziarski, R. (2007). Human peptidoglycan recognition proteins require zinc to kill both gram-positive and gram-negative bacteria and are synergistic with antibacterial peptides. The Journal of Immunology, 178(5), 3116-3125. https://doi.org/10.4049/jimmunol.178.5.3116