6-[

Animals Brain / diagnostic imaging Iodides / metabolism Iodine Radioisotopes / chemistry Male Mice, Inbred C57BL Mice, Knockout Positron-Emission Tomography Purines / chemical synthesis Radiopharmaceuticals / chemical synthesis Symporters / genetics

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 02 2020
Historique:
pubmed: 7 2 2020
medline: 1 9 2020
entrez: 7 2 2020
Statut: ppublish

Résumé

Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in the activity of the sodium iodide symporter (NIS). No radiotracers are currently available for imaging brain NIS activity. Here, we synthesized 6-[

Identifiants

DOI: 10.1021/acs.jmedchem.9b02096 PMID: 32026684
pubmed: 32026684
doi: 10.1021/acs.jmedchem.9b02096
doi:

Substances chimiques

6-((124)I)Iodo-9-pentylpurine 0
Iodides 0
Iodine Radioisotopes 0
Iodine-124 0
Purines 0
Radiopharmaceuticals 0
Symporters 0
sodium-iodide symporter 4XE5NDT4K1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1717-1723

Auteurs

Toshimitsu Okamura (T)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
ORCID: 0000-0001-7117-6917

Satoshi Tsukamoto (S)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Kotaro Nagatsu (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Maki Okada (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Katsuyuki Minegishi (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Takayuki Tatsumi (T)

Comprehensive Reproductive Medicine, Regulation of Internal Environment and Reproduction, Graduate School , Tokyo Medical and Dental University , Tokyo 113-8519 , Japan.

Aya Sugyo (A)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Tatsuya Kikuchi (T)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Hidekatsu Wakizaka (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Hideki Ishii (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Atsushi B Tsuji (AB)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.

Ming-Rong Zhang (MR)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
ORCID: 0000-0002-3001-9605

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › 6-[
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › 6-[
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'iode › Iodures › 6-[
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes de l'iode › 6-[
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › 6-[
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › 6-[
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › 6-[
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › 6-[
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › 6-[
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › 6-[