Heterocycle Compounds with Antimicrobial Activity.
Antibacterial
antifungal
benzothiazole
microdilution methods
thiadiazole
thiazole
thiazolidinone.
Journal
Current pharmaceutical design
ISSN: 1873-4286
Titre abrégé: Curr Pharm Des
Pays: United Arab Emirates
ID NLM: 9602487
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
10
2019
accepted:
19
11
2019
pubmed:
7
2
2020
medline:
4
11
2020
entrez:
7
2
2020
Statut:
ppublish
Résumé
Bacterial infections are a growing problem worldwide causing morbidity and mortality mainly in developing countries. Moreover, the increased number of microorganisms, developing multiple resistances to known drugs, due to abuse of antibiotics, is another serious problem. This problem becomes more serious for immunocompromised patients and those who are often disposed to opportunistic fungal infections. The objective of this manuscript is to give an overview of new findings in the field of antimicrobial agents among five-membered heterocyclic compounds. These heterocyclic compounds especially five-membered attracted the interest of the scientific community not only for their occurrence in nature but also due to their wide range of biological activities. To reach our goal, a literature survey that covers the last decade was performed. As a result, recent data on the biological activity of thiazole, thiazolidinone, benzothiazole and thiadiazole derivatives are mentioned. It should be mentioned that despite the progress in the development of new antimicrobial agents, there is still room for new findings. Thus, research still continues.
Sections du résumé
BACKGROUND
Bacterial infections are a growing problem worldwide causing morbidity and mortality mainly in developing countries. Moreover, the increased number of microorganisms, developing multiple resistances to known drugs, due to abuse of antibiotics, is another serious problem. This problem becomes more serious for immunocompromised patients and those who are often disposed to opportunistic fungal infections.
OBJECTIVE
The objective of this manuscript is to give an overview of new findings in the field of antimicrobial agents among five-membered heterocyclic compounds. These heterocyclic compounds especially five-membered attracted the interest of the scientific community not only for their occurrence in nature but also due to their wide range of biological activities.
METHODS
To reach our goal, a literature survey that covers the last decade was performed.
RESULTS
As a result, recent data on the biological activity of thiazole, thiazolidinone, benzothiazole and thiadiazole derivatives are mentioned.
CONCLUSION
It should be mentioned that despite the progress in the development of new antimicrobial agents, there is still room for new findings. Thus, research still continues.
Identifiants
pubmed: 32026773
pii: CPD-EPUB-104227
doi: 10.2174/1381612826666200206093815
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Heterocyclic Compounds
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
867-904Informations de copyright
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