Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis.

Mental health UK Biobank alcohol disorders cohort study depressive disorders

Journal

BJPsych open
ISSN: 2056-4724
Titre abrégé: BJPsych Open
Pays: England
ID NLM: 101667931

Informations de publication

Date de publication:
06 Feb 2020
Historique:
entrez: 7 2 2020
pubmed: 7 2 2020
medline: 7 2 2020
Statut: epublish

Résumé

UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential. Describe the development, implementation and results of this questionnaire. An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use. A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45-82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation. The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.

Sections du résumé

BACKGROUND BACKGROUND
UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential.
AIMS OBJECTIVE
Describe the development, implementation and results of this questionnaire.
METHOD METHODS
An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use.
RESULTS RESULTS
A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45-82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation.
CONCLUSIONS CONCLUSIONS
The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.

Identifiants

DOI: 10.1192/bjo.2019.100 PMID: 32026800 PMC: PMC7176892
pubmed: 32026800
doi: 10.1192/bjo.2019.100
pii: S2056472419001005
pmc: PMC7176892
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e18

Subventions

Organisme : Department of Health
ID : NIHR-RP-R3-12-011
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12028
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : DTF/14/03
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom

Références

PLoS One. 2018 Mar 26;13(3):e0195002
pubmed: 29579109
Lancet. 2015 Dec 5;386(10010):2257-74
pubmed: 26382241
BMJ Open. 2016 Mar 01;6(3):e008721
pubmed: 26932138
Epidemiology. 2004 Sep;15(5):615-25
pubmed: 15308962
Am J Epidemiol. 2016 Jun 15;183(12):1149-58
pubmed: 27188935
Curr Opin Psychiatry. 2007 Jul;20(4):359-64
pubmed: 17551351
Lancet. 2007 Sep 8;370(9590):859-77
pubmed: 17804063
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034
pubmed: 28641372
Int J Geriatr Psychiatry. 2017 Dec;32(12):e83-e92
pubmed: 28128869
Br J Pain. 2015 Nov;9(4):203-12
pubmed: 26526341
J Intern Med. 2019 Oct;286(4):389-397
pubmed: 31283063
J Affect Disord. 2015 Feb 1;172:337-46
pubmed: 25451435
Annu Rev Clin Psychol. 2016;12:435-63
pubmed: 26845519
Nord J Psychiatry. 2011 Sep;65(4):226-37
pubmed: 21138402
Lancet. 2012 Jul 7;380(9836):37-43
pubmed: 22579043
Int J Methods Psychiatr Res. 2019 Sep;28(3):e1796
pubmed: 31397039
J Clin Epidemiol. 2004 Oct;57(10):1096-103
pubmed: 15528061
Am J Hypertens. 2015 Nov;28(11):1295-302
pubmed: 25911639
Psychol Med. 2019 May 2;:1-10
pubmed: 31044683
PLoS One. 2013 Nov 25;8(11):e75362
pubmed: 24282498
Soc Psychiatry Psychiatr Epidemiol. 2012 May;47(5):691-6
pubmed: 21533819
BMC Public Health. 2009 Oct 08;9:376
pubmed: 19811664
Am J Epidemiol. 2010 Dec 1;172(11):1306-14
pubmed: 20843863
Lancet Psychiatry. 2017 Jul;4(7):525-526
pubmed: 28552500
J Ment Health. 2016 Jun;25(3):185-8
pubmed: 27068151
Epidemiology. 2016 Jul;27(4):525-30
pubmed: 27075676
BMJ Open. 2014 Jan 29;4(1):e004295
pubmed: 24477317
Gen Hosp Psychiatry. 2014 Jan-Feb;36(1):19-25
pubmed: 24144521
Arch Gen Psychiatry. 2011 Jun;68(6):600-8
pubmed: 21646577
Int J Epidemiol. 2019 Jul 01;:
pubmed: 31263887
Neuron. 2019 Apr 3;102(1):91-103
pubmed: 30946830
Int J Methods Psychiatr Res. 2009 Dec;18(4):221-8
pubmed: 20052690
J Epidemiol Community Health. 2008 Mar;62(3):216-23
pubmed: 18272736
Depress Anxiety. 2010 Apr;27(4):351-64
pubmed: 20037917
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379

Auteurs

Katrina A S Davis (KAS)

Researcher, Institute of Psychiatry, Psychology and Neuroscience, King's College London; and South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre, UK.
ORCID: 0000-0001-5945-4646

Jonathan R I Coleman (JRI)

Lecturer in Statistical Genetics, Institute of Psychiatry, Psychology and Neuroscience, King's College London; and South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre, UK.

Mark Adams (M)

Data Scientist, Division of Psychiatry, University of Edinburgh, UK.

Naomi Allen (N)

Professor, University of Oxford; and Chief Scientist, UK Biobank, Nuffield Department of Population Health, University of Oxford Big Data Institute, UK.

Gerome Breen (G)

Professor of Psychiatric Genetics, Institute of Psychiatry, Psychology and Neuroscience, King's College London; and South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre, UK.

Breda Cullen (B)

Senior Lecturer, Institute of Health and Wellbeing, University of Glasgow, UK.

Chris Dickens (C)

Professor of Psychological Medicine, Institute of Health Research, University of Exeter Medical School, University of Exeter, UK.

Elaine Fox (E)

Professor of Psychology and Affective Neuroscience, Department of Experimental Psychology, University of Oxford, UK.

Nick Graham (N)

Clinical Lecturer in General Psychiatry, Institute of Health and Wellbeing, University of Glasgow, UK.

Jo Holliday (J)

Senior Research Facilitator, University of Oxford; and UK Biobank: UK Biobank, Nuffield Department of Population Health, University of Oxford Big Data Institute, UK.

Louise M Howard (LM)

NIHR Research Professor in Women's Mental Health and NIHR Senior Investigator, Section of Women's Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
ORCID: 0000-0001-9942-744X

Ann John (A)

Professor of Public Health and Psychiatry and Consultant Public Health Medicine, Population Data Science, Farr Institute of Health Informatics Research, Swansea University Medical School, Swansea University; and Public Health Wales NHS Trust, UK.

William Lee (W)

Consultant Liaison Psychiatrist and Honorary Clinical Senior Lecturer, Devon Partnership NHS Trust; and University of Exeter Medical School, University of Exeter, UK.

Rose McCabe (R)

Professor of Clinical Communication, School of Health Sciences, City, University of London, UK.

Andrew McIntosh (A)

Professor of Biological Psychiatry, Division of Psychiatry, University of Edinburgh, UK.
ORCID: 0000-0002-0198-4588

Robert Pearsall (R)

Consultant Psychiatrist and Honorary Clinical Senior Lecturer in Psychiatry, Institute of Health and Wellbeing, University of Glasgow, UK.
ORCID: 0000-0002-6697-9157

Daniel J Smith (DJ)

Lecturer in Psychiatry, Institute of Health and Wellbeing, University of Glasgow, UK.
ORCID: 0000-0002-2267-1951

Cathie Sudlow (C)

Director of the British Heart Foundation Data Science Centre, BHF Data Science Centre; Former Chief Scientist, UK Biobank; and Chair of Neurology and Clinical Epidemiology, Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, UK.

Joey Ward (J)

Researcher, Institute of Health and Wellbeing, University of Glasgow, UK.

Stan Zammit (S)

Professor of Psychiatric Epidemiology, Centre for Academic Mental Health, University of Bristol; and Institute of Psychological Medicine and Clinical Neurosciences, University of Cardiff, Cardiff University School of Medicine, UK.

Matthew Hotopf (M)

Director, National Institute of Health Research Biomedical Research Centre at the Maudsley; Institute of Psychiatry, Psychology and Neuroscience, King's College London; and South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre, UK.

Classifications MeSH