Long-term changes of stimulation intensities in hypoglossal nerve stimulation.
OSAS
hypoglossal nerve stimulation
stimulation intensity
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
pubmed:
7
2
2020
medline:
24
6
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
Hypoglossal nerve stimulation (HNS) is a novel therapy in the treatment of obstructive sleep apnea. Previous studies have focused on the effectiveness of HNS, but there are no studies specifically investigating the long-term changes of the stimulation intensities in HNS. Increasing stimulation intensity requirements have been reported in the past in other peripheral nerve stimulation therapies. The aim of this study was to investigate the development of stimulation intensities over the observation period of 4 years. All patients who were implanted with an HNS system since December 2013 and maintained a bipolar configuration over the observation period were included. Sensation threshold (ST), functional threshold, the titrated stimulation intensity (SI), and the apnea-hypopnea index (AHI) were recorded. A total of 82 patients were enrolled (sex: 69 men, 13 women, age: 60 ± 11 years, body mass index: 29. 8 ± 4.0 kg/m²). Two months after surgery, the median ST was 0.8 ± 0.5 V. During the observation period of 48 months, no significant change of ST was observed. The median ST was 1.0 ± 0.4 V (P = 0.93) at 48 months. Similar results were found for functional threshold and the titrated stimulation intensity. There was a significant reduction of the baseline median AHI when compared with the median AHI at 1, 12, 24, 36 and 48 months after surgery (P < 0.05). The stimulation intensities in HNS show no significant changes over 4 years. Despite the constant stimulation intensity, AHI was significantly reduced. This indicates that the stimulation threshold of the hypoglossal nerve does not change over time with this therapy.
Identifiants
pubmed: 32026804
doi: 10.5664/jcsm.8320
pmc: PMC7954005
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1775-1780Informations de copyright
© 2020 American Academy of Sleep Medicine.
Références
Laryngoscope. 2018 Mar;128(3):756-762
pubmed: 28681961
N Engl J Med. 1996 Jan 11;334(2):99-104
pubmed: 8531966
Sleep. 2015 Oct 01;38(10):1593-8
pubmed: 26158895
Sleep Med Rev. 2011 Dec;15(6):343-56
pubmed: 21652236
J Sports Sci Med. 2005 Dec 01;4(4):395-405
pubmed: 24501553
Somatosens Mot Res. 2017 Dec;34(4):242-247
pubmed: 29320897
Ann Neurol. 2008 Apr;63(4):507-12
pubmed: 18300313
Sleep Breath. 2019 Mar;23(1):235-241
pubmed: 29956103
N Engl J Med. 2014 Jan 9;370(2):139-49
pubmed: 24401051
Neurotherapeutics. 2008 Jan;5(1):100-6
pubmed: 18164488
Respir Med. 2018 Jul;140:77-81
pubmed: 29957285
Eur Respir J. 2019 Jan 3;53(1):
pubmed: 30487205
Prog Neurol Surg. 2011;24:189-202
pubmed: 21422789
Laryngoscope. 2016 Sep;126 Suppl 7:S12-6
pubmed: 27572119
Otolaryngol Head Neck Surg. 2018 Jul;159(1):194-202
pubmed: 29582703
Science. 1967 Jan 6;155(3758):108-9
pubmed: 6015561
Otolaryngol Head Neck Surg. 2017 Feb;156(2):378-384
pubmed: 28025918
Laryngoscope. 2016 Dec;126(12):2852-2858
pubmed: 27345949
Laryngoscope. 2018 Aug;128(8):1970-1976
pubmed: 29280488
Front Neurosci. 2017 Sep 21;11:523
pubmed: 28983236
Chest. 2018 Feb;153(2):574-575
pubmed: 29406226
N Engl J Med. 2000 May 11;342(19):1378-84
pubmed: 10805822
Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39
pubmed: 11991871