Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival.
Animals
Apoptosis
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dentate Gyrus
/ cytology
Genotyping Techniques
Hippocampus
/ cytology
Immunohistochemistry
Male
Mice
Mice, Knockout
Neural Stem Cells
/ cytology
Neurogenesis
/ drug effects
Neuronal Plasticity
/ drug effects
Neurons
/ cytology
Phenylethyl Alcohol
/ analogs & derivatives
Proto-Oncogene Proteins c-fos
/ metabolism
aging
diet
hippocampus
neural stem cells
neurogenic stimuli
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
26
10
2019
revised:
31
12
2019
accepted:
16
01
2020
pubmed:
7
2
2020
medline:
22
1
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
The dentate gyrus of the hippocampus is one of two brain areas generating throughout life new neurons, which contribute to the formation of episodic/associative memories. During aging, the production of new neurons decreases and a cognitive decline occurs. Dietary factors influence neuronal function and synaptic plasticity; among them the phenolic compound hydroxytyrosol (HTyr), present in olive oil, displays neuroprotective effects. As age impacts primarily on the hippocampus-dependent cognitive processes, we wondered whether HTyr could stimulate hippocampal neurogenesis in vivo in adult and aged wild-type mice as well as in the B-cell translocation 1 gene (Btg1) knockout mouse model of accelerated neural aging. We found that treatment with HTyr activates neurogenesis in the dentate gyrus of adult, aged, and Btg1-null mice, by increasing survival of new neurons and decreasing apoptosis. Notably, however, in the aged and Btg1-null dentate gyrus, HTyr treatment also stimulates the proliferation of stem and progenitor cells, whereas in the adult dentate gyrus HTyr lacks any proliferative effect. Moreover, the new neurons generated in aged mice after HTyr treatment are recruited to existing circuits, as shown by the increase of BrdU
Identifiants
pubmed: 32027412
doi: 10.1096/fj.201902643R
doi:
Substances chimiques
Proto-Oncogene Proteins c-fos
0
3,4-dihydroxyphenylethanol
10597-60-1
Phenylethyl Alcohol
ML9LGA7468
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4512-4526Informations de copyright
© 2020 Federation of American Societies for Experimental Biology.
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