Endosomal Escape of Peptide-Photosensitizer Conjugates Is Affected by Amino Acid Sequences near the Photosensitizer.

Amino Acid Sequence Animals Apoptosis / drug effects CHO Cells Cell-Penetrating Peptides / chemistry Cricetulus Endocytosis Endosomes / metabolism Photochemical Processes Photosensitizing Agents / chemistry

Journal

Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319

Informations de publication

Date de publication:
18 03 2020
Historique:
pubmed: 7 2 2020
medline: 12 2 2021
entrez: 7 2 2020
Statut: ppublish

Résumé

Cell-penetrating peptides (CPPs) are widely used for the intracellular delivery of peptides and proteins, but CPP fusion peptides and proteins are often transported by endocytosis and trapped in endosomes. Photochemical internalization (PCI) is a method for the endosomal escape of the trapped peptide or protein and release into the cytosol using light and photosensitizers. In PCI, endosomal membranes are thought to be destabilized by singlet oxygen (

Identifiants

DOI: 10.1021/acs.bioconjchem.0c00046 PMID: 32027488
pubmed: 32027488
doi: 10.1021/acs.bioconjchem.0c00046
doi:

Substances chimiques

Cell-Penetrating Peptides 0
Photosensitizing Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

916-922

Auteurs

Yuichi Miyoshi (Y)

Department of Medical Bioengineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.

Maho Kadono (M)

Department of Medical Bioengineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.

Shigetoshi Okazaki (S)

Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

Ayano Nishimura (A)

Department of Applied Chemistry, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.

Mizuki Kitamatsu (M)

Department of Applied Chemistry, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.

Kazunori Watanabe (K)

Department of Medical Bioengineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.

Takashi Ohtsuki (T)

Department of Medical Bioengineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
ORCID: 0000-0002-3183-5305

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Eucaryotes › Animaux › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides de pénétration cellulaire › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Phénomènes chimiques › Processus photochimiques › Endosomal Escape of Peptide-Photosensitizer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Endosomal Escape of Peptide-Photosensitizer...