Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.
Adolescent
Adult
Age Factors
Betacoronavirus
/ isolation & purification
COVID-19
COVID-19 Testing
China
/ epidemiology
Clinical Laboratory Techniques
Coronavirus Infections
/ complications
Cough
/ etiology
Female
Fever
/ etiology
Humans
Leukocyte Count
Lung
/ diagnostic imaging
Male
Middle Aged
Pneumonia, Viral
/ complications
Real-Time Polymerase Chain Reaction
Retrospective Studies
SARS-CoV-2
Tomography, X-Ray Computed
Young Adult
Journal
Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
7
2
2020
medline:
21
3
2020
entrez:
7
2
2020
Statut:
ppublish
Résumé
BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated.ResultsFifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocyte count. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients, and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement, while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer (431 of 712 lesions vs 129 of 612 lesions;
Identifiants
pubmed: 32027573
doi: 10.1148/radiol.2020200274
pmc: PMC7233366
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
210-217Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Références
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Comput Assist Tomogr. 2004 Nov-Dec;28(6):790-5
pubmed: 15538152
J Thorac Imaging. 2006 Nov;21(4):259-64
pubmed: 17110849
Influenza Other Respir Viruses. 2012 Nov;6(6):e114-9
pubmed: 22551111
Radiographics. 2018 May-Jun;38(3):719-739
pubmed: 29757717
Radiology. 2013 Sep;268(3):882-9
pubmed: 23821754
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Radiology. 2020 Apr;295(1):18
pubmed: 32003646
Nature. 2013 Nov 28;503(7477):535-8
pubmed: 24172901
Medicine (Baltimore). 2018 Mar;97(12):e0194
pubmed: 29561442
Int J Infect Dis. 2020 Feb;91:264-266
pubmed: 31953166
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143