Synthesis of flavonoids nitrogen mustard derivatives and study on their antitumor activity in vitro.
Anticancer
Cell apoptosis
Cell cycle
Flavonoids
Nitrogen mustard derivatives
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
19
09
2019
revised:
25
12
2019
accepted:
21
01
2020
pubmed:
7
2
2020
medline:
25
2
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
Several novel flavonoids nitrogen mustard derivatives were synthesized and evaluated for antiproliferative activity against seven human cancer cell lines (HeLa, A549, HepG2, MCF7, SH-SY5Y, PC-3, DU145) by the MTT assay in vitro. The resulting IC
Identifiants
pubmed: 32028061
pii: S0045-2068(19)31538-X
doi: 10.1016/j.bioorg.2020.103613
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Flavonoids
0
Nitrogen Mustard Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103613Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.