In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles.
Intracellular water lifetime
Iron oxide particles
Low field relaxometry (NMRD)
Magnetic resonance imaging
Tumour associated macrophages
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
25
07
2019
revised:
27
12
2019
accepted:
22
01
2020
pubmed:
7
2
2020
medline:
15
5
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
Tumour-associated macrophages (TAM) are forced by cancer cells to adopt an anti-inflammatory phenotype and secrete factors to promote tumour invasion thus being responsible for poor patient outcome. The aim of this study is to develop a clinically applicable, non-invasive method to obtain a quantitative TAM detection in tumour tissue. The method is based on longitudinal proton relaxation rate (R
Identifiants
pubmed: 32028168
pii: S0142-9612(20)30051-X
doi: 10.1016/j.biomaterials.2020.119805
pii:
doi:
Substances chimiques
Contrast Media
0
Ferric Compounds
0
ferric oxide
1K09F3G675
Ferrosoferric Oxide
XM0M87F357
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119805Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.