Therapeutic Options for the Treatment of Interstitial Lung Disease Related to Connective Tissue Diseases. A Narrative Review.
antifibrotic drugs
clinical trials
connective tissue disease
immunoppressants
interstitial lung disease
treatment
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
03 Feb 2020
03 Feb 2020
Historique:
received:
29
12
2019
revised:
21
01
2020
accepted:
23
01
2020
entrez:
8
2
2020
pubmed:
8
2
2020
medline:
8
2
2020
Statut:
epublish
Résumé
Interstitial lung disease (ILD) is one of the most serious pulmonary complications of connective tissue diseases (CTDs) and it is characterized by a deep impact on morbidity and mortality. Due to the poor knowledge of CTD-ILD's natural history and due to the difficulties related to design of randomized control trials, there is a lack of prospective data about the prevalence, follow-up, and therapeutic efficacy. For these reasons, the choice of therapy for CTD-ILD is currently very challenging and still largely based on experts' opinion. Treatment is often based on steroids and conventional immunosuppressive drugs, but the recent publication of the encouraging results of the INBUILD trial has highlighted a possible effective and safe use of antifibrotic drugs as a new therapeutic option for these subjects. Aim of this review is to summarize the available data and recent advances about therapeutic strategies for ILD in the context of various CTD, such as systemic sclerosis, idiopathic inflammatory myopathy and Sjogren syndrome, systemic lupus erythematosus, mixed connective tissue disease and undifferentiated connective tissue disease, and interstitial pneumonia with autoimmune features, focusing also on ongoing clinical trials.
Identifiants
pubmed: 32028635
pii: jcm9020407
doi: 10.3390/jcm9020407
pmc: PMC7073957
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Br J Rheumatol. 1995 Dec;34(12):1187-8
pubmed: 8608369
Lancet. 2016 Jun 25;387(10038):2630-2640
pubmed: 27156934
Br J Dermatol. 2018 Mar;178(3):650-658
pubmed: 28906550
Autoimmun Rev. 2015 Nov;14(11):1072-8
pubmed: 26209905
Respir Med. 2016 Dec;121:91-99
pubmed: 27888997
Clin Rheumatol. 2006 Mar;25(2):205-12
pubmed: 16228107
Sarcoidosis Vasc Diffuse Lung Dis. 2014 Oct 20;31(3):235-8
pubmed: 25363224
Chest. 2008 Feb;133(2):455-60
pubmed: 18071023
Nat Rev Rheumatol. 2012 May 01;8(7):399-411
pubmed: 22549247
Semin Arthritis Rheum. 2017 Apr;46(5):625-631
pubmed: 27839742
Clin Rheumatol. 2010 Oct;29(10):1167-8
pubmed: 20532938
Chest. 2006 Nov;130(5):1489-95
pubmed: 17099028
Ann Rheum Dis. 2007 Mar;66(3):351-7
pubmed: 16950808
N Engl J Med. 2018 Jan 4;378(1):35-47
pubmed: 29298160
Rheumatology (Oxford). 2015 Aug;54(8):1420-8
pubmed: 25740830
Rheumatology (Oxford). 2010 Sep;49(9):1713-9
pubmed: 20498012
Transpl Int. 2010 May 1;23(5):e10-1
pubmed: 20210936
Autoimmunity. 2006 May;39(3):205-15
pubmed: 16769654
Eur Respir J. 2016 Jan;47(1):344-5
pubmed: 26721966
Clin Rheumatol. 2009 Jun;28(6):639-46
pubmed: 19247576
J Rheumatol. 2019 May;46(5):509-517
pubmed: 30647164
Chest. 1974 Apr;65(4):403-7
pubmed: 4819244
Arthritis Rheum. 2011 Nov;63(11):3540-6
pubmed: 21769849
Arthritis Rheumatol. 2015 May;67(5):1314-22
pubmed: 25581250
Clin Exp Rheumatol. 2009 Jan-Feb;27(1):168-9
pubmed: 19327251
Transplantation. 2013 Apr 15;95(7):975-80
pubmed: 23545509
Lupus. 2015 Jan;24(1):3-9
pubmed: 25297551
J Surg Res. 2014 Jun 15;189(2):232-7
pubmed: 24726692
Arthritis Res Ther. 2017 Dec 21;19(1):284
pubmed: 29268795
Respiration. 2015;90(4):265-74
pubmed: 26461464
BMJ Case Rep. 2015 May 14;2015:
pubmed: 25976199
Ann Am Thorac Soc. 2016 Nov;13(11):2045-2056
pubmed: 27560196
J Heart Lung Transplant. 2018 Jul;37(7):903-911
pubmed: 29628135
JAMA. 2014 Jun 25;311(24):2490-8
pubmed: 25058083
J Rheumatol. 2013 May;40(5):640-6
pubmed: 23457378
Respirol Case Rep. 2014 Jun;2(2):70-2
pubmed: 25473571
Nat Rev Rheumatol. 2016 Aug;12(8):456-71
pubmed: 27411907
Ann Am Thorac Soc. 2016 Jun;13(6):793-802
pubmed: 27078625
Ann Rheum Dis. 2013 Jun;72(6):1026-31
pubmed: 23264337
Respir Med. 2008 Jan;102(1):150-5
pubmed: 17822892
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1182-5
pubmed: 11673206
Lancet Respir Med. 2016 Sep;4(9):708-719
pubmed: 27469583
Rheumatology (Oxford). 2005 May;44(5):656-61
pubmed: 15716315
J Rheumatol. 2017 Nov;44(11):1612-1618
pubmed: 28864644
Ann Rheum Dis. 2015 Jun;74(6):1188-94
pubmed: 24442885
Clin Rheumatol. 2017 Jun;36(6):1261-1268
pubmed: 28324200
Autoimmun Rev. 2016 Jan;15(1):61-70
pubmed: 26384526
Autoimmun Rev. 2017 Jan;16(1):48-54
pubmed: 27682894
Arthritis Rheum. 1999 May;42(5):899-909
pubmed: 10323445
Front Med (Lausanne). 2017 Oct 23;4:176
pubmed: 29109947
Rheumatology (Oxford). 2018 Feb 1;57(2):204-205
pubmed: 28977485
J Pain Symptom Manage. 2019 Dec 28;:
pubmed: 31887400
Rheumatology (Oxford). 2010 May;49(5):1013
pubmed: 20032227
Rheum Dis Clin North Am. 2015 Aug;41(3):439-57
pubmed: 26210128
Respir Med. 2013 Jun;107(6):890-6
pubmed: 23517887
J Rheumatol. 2013 Apr;40(4):484-92
pubmed: 23418387
Clin Rheumatol. 2011 Aug;30(8):1021-8
pubmed: 21340495
J Rheumatol. 2002 Feb;29(2):298-304
pubmed: 11842824
Clin Exp Rheumatol. 2005 Sep-Oct;23(5):724
pubmed: 16173257
Respir Med. 2009 Jun;103(6):846-53
pubmed: 19181509
Arthritis Res Ther. 2014 Jul 08;16(4):R144
pubmed: 25007944
Clin Rheumatol. 2015 Jan;34(1):99-105
pubmed: 25367345
J Clin Rheumatol. 2017 Dec;23(8):411-415
pubmed: 28926468
Rheumatology (Oxford). 2015 Jan;54(1):39-44
pubmed: 24764266
Rheumatology (Oxford). 2007 Mar;46(3):442-5
pubmed: 16899504
J Clin Rheumatol. 2011 Dec;17(8):454
pubmed: 22126805
Arthritis Rheum. 2011 Nov;63(11):3439-47
pubmed: 21702020
Arthritis Care Res (Hoboken). 2010 Oct;62(10):1496-501
pubmed: 20506189
Medicine (Baltimore). 2004 Jan;83(1):35-42
pubmed: 14747766
PLoS One. 2014 Jun 06;9(6):e98824
pubmed: 24905449
Chest. 2016 Nov;150(5):1118-1128
pubmed: 27102182
Lancet Respir Med. 2020 Feb;8(2):147-157
pubmed: 31578169
Ann Thorac Med. 2017 Oct-Dec;12(4):294-297
pubmed: 29118864
Semin Arthritis Rheum. 1990 Aug;20(1):48-56
pubmed: 2218553
Respir Med. 2016 Oct;119:150-154
pubmed: 27692137
Lung India. 2015 Jan-Feb;32(1):50-2
pubmed: 25624597
Chest. 2009 Nov;136(5):1333-1340
pubmed: 19892673
Medicine (Baltimore). 2008 Jul;87(4):210-9
pubmed: 18626304
Respir Med. 2012 Apr;106(4):581-7
pubmed: 22280877
Clin Transplant. 2009 Mar-Apr;23(2):178-83
pubmed: 19210528
Rheumatology (Oxford). 2016 Jul;55(7):1318-24
pubmed: 27060110
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):170-176
pubmed: 27049330
Rheumatol Int. 2009 Oct;29(12):1499-502
pubmed: 19184665
Lancet. 1999 May 22;353(9166):1762-3
pubmed: 10347992
Curr Opin Rheumatol. 2016 May;28(3):236-45
pubmed: 27027811
Curr Opin Rheumatol. 1998 Nov;10(6):579-83
pubmed: 9812219
Mod Rheumatol. 2003 Sep;13(3):231-8
pubmed: 24387210
Arthritis Res Ther. 2018 Jan 30;20(1):17
pubmed: 29382380
N Engl J Med. 2014 May 29;370(22):2071-82
pubmed: 24836310
J Clin Apher. 2013 Dec;28(6):422-5
pubmed: 23908096
Ann Am Thorac Soc. 2016 Jun;13(6):784-92
pubmed: 26669584
Semin Arthritis Rheum. 2015 Feb;44(4):428-36
pubmed: 25300701
Arthritis Rheum. 2006 Dec;54(12):3962-70
pubmed: 17133610
Arthritis Res Ther. 2010;12(4):213
pubmed: 20735863
Scand J Rheumatol. 2011;40(4):327-8
pubmed: 21623666
Lung. 2018 Aug;196(4):409-416
pubmed: 29785507
Clin Exp Rheumatol. 2012 Mar-Apr;30(2 Suppl 71):S17-22
pubmed: 22244622
Am J Respir Crit Care Med. 2008 Jun 1;177(11):1248-54
pubmed: 18369202
Drug Des Devel Ther. 2015 Oct 23;9:5755-62
pubmed: 26566367
J Clin Apher. 2015 Dec;30(6):375-9
pubmed: 25727180
Eur Respir J. 1997 Dec;10(12):2907-12
pubmed: 9493684
Int J Med Sci. 2017 Feb 23;14(3):191-200
pubmed: 28367079
Arthritis Rheum. 2011 Sep;63(9):2797-808
pubmed: 21547897
Semin Arthritis Rheum. 2003 Apr;32(5):273-84
pubmed: 12701038
Curr Opin Pulm Med. 2017 Sep;23(5):411-417
pubmed: 28582317
J Rheumatol. 2016 Sep;43(9):1672-9
pubmed: 27370878
N Engl J Med. 2019 Jun 27;380(26):2518-2528
pubmed: 31112379
Arthritis Rheum. 1998 Sep;41(9):1613-9
pubmed: 9751093
Clin Exp Rheumatol. 2013 May-Jun;31(3):436-9
pubmed: 23465087
Intern Med. 2010;49(5):361-9
pubmed: 20190466
Semin Arthritis Rheum. 2015 Feb;44(4):437-44
pubmed: 25282395
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):e388-e389
pubmed: 28261880
Clin Rheumatol. 2011 Nov;30(11):1393-8
pubmed: 21881859
Rheumatology (Oxford). 2010 Feb;49(2):271-80
pubmed: 19447770
J Rheumatol. 2008 Jun;35(6):1064-72
pubmed: 18464307
Chest. 2011 Feb;139(2):441-443
pubmed: 21285059
Eur Respir J. 2015 Oct;46(4):976-87
pubmed: 26160873
Arthritis Rheum. 2006 Dec;54(12):3954-61
pubmed: 17133609
Respirology. 2014 Apr;19(3):353-9
pubmed: 24286447
PLoS One. 2015 Nov 05;10(11):e0133702
pubmed: 26539981
Lancet. 2011 Aug 6;378(9790):498-506
pubmed: 21777972
Respir Med. 2016 Dec;121:117-122
pubmed: 27888985
Respir Med Case Rep. 2019 Feb 28;26:317-320
pubmed: 30931251
Transplant Proc. 2014 Nov;46(9):3147-53
pubmed: 25420846
Arthritis Rheumatol. 2017 Jul;69(7):1451-1460
pubmed: 28376288
Joint Bone Spine. 2018 Jan;85(1):79-84
pubmed: 28408277
Chest. 2007 Jul;132(1):214-20
pubmed: 17400667
Rheumatology (Oxford). 2014 Sep;53(9):1630-8
pubmed: 24706995
Autoimmunity. 2005 Aug;38(5):383-92
pubmed: 16227154
J Clin Rheumatol. 2017 Mar;23(2):87-93
pubmed: 28225510
Chest. 2019 Nov;156(5):896-906
pubmed: 31238042
Korean J Intern Med. 2017 Jul;32(4):600-610
pubmed: 28704913
Ann Rheum Dis. 2017 Aug;76(8):1327-1339
pubmed: 27941129
Curr Rheumatol Rep. 2012 Jun;14(3):264-74
pubmed: 22367479
Autoimmunity. 2006 May;39(3):233-41
pubmed: 16769657
Chest. 2006 Jul;130(1):30-6
pubmed: 16840379
J Pharmacol Exp Ther. 2014 May;349(2):209-20
pubmed: 24556663
Rheumatology (Oxford). 2007 Jan;46(1):124-30
pubmed: 16754626
Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48
pubmed: 24032382
PLoS One. 2017 Nov 9;12(11):e0187580
pubmed: 29121645
Respirol Case Rep. 2017 Jan 12;5(2):e00215
pubmed: 28096998
J Bras Pneumol. 2011 Jan-Feb;37(1):100-9
pubmed: 21390438
Trials. 2017 Jun 15;18(1):275
pubmed: 28619061
J Heart Lung Transplant. 2017 Jul;36(7):763-769
pubmed: 28131664
Lung. 2009 May-Jun;187(3):201-6
pubmed: 19387736
Chest. 2011 Aug;140(2):562-563
pubmed: 21813543
Intern Med. 1998 Aug;37(8):669-73
pubmed: 9745852
Curr Rheumatol Rep. 2013 Sep;15(9):359
pubmed: 23888366
Respir Med. 2013 Dec;107(12):2081-7
pubmed: 24113572
Autoimmun Rev. 2012 Mar;11(5):335-40
pubmed: 21985773
Chest. 2013 Mar;143(3):814-824
pubmed: 23460159
Cochrane Database Syst Rev. 2014 Oct 06;(10):CD006322
pubmed: 25284270
N Engl J Med. 2019 Oct 31;381(18):1718-1727
pubmed: 31566307
Arthritis Rheum. 2005 Aug;52(8):2439-46
pubmed: 16052580
Am J Respir Crit Care Med. 2007 Nov 15;176(10):1026-34
pubmed: 17717203
Tohoku J Exp Med. 2016;239(4):297-305
pubmed: 27487743
Eur Respir J. 2003 Aug;22(2):245-50
pubmed: 12952255
Rheumatology (Oxford). 2009 Aug;48(8):968-71
pubmed: 19531628
J Rheumatol. 2015 Nov;42(11):2168-71
pubmed: 25729034
Arthritis Care Res (Hoboken). 2015 Sep;67(9):1237-1245
pubmed: 25777803
Scand J Rheumatol. 2003;32(3):181-3
pubmed: 12892257
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):75-81
pubmed: 28664834
Chest. 2010 Dec;138(6):1464-74
pubmed: 21138882
Semin Respir Crit Care Med. 2014 Apr;35(2):249-54
pubmed: 24668539
N Engl J Med. 2006 Jun 22;354(25):2655-66
pubmed: 16790698
Ann Rheum Dis. 2012 Dec;71(12):2061-2
pubmed: 22689320