Intranasal dexmedetomidine in elderly subjects with or without beta blockade: a randomised double-blind single-ascending-dose cohort study.
beta-blockade
complication
dexmedetomidine
elderly
hypotension
intranasal
safety
sedation
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
03 Feb 2020
03 Feb 2020
Historique:
received:
16
03
2019
revised:
18
11
2019
accepted:
16
12
2019
entrez:
8
2
2020
pubmed:
8
2
2020
medline:
8
2
2020
Statut:
aheadofprint
Résumé
The aim of this double-blind, placebo-controlled, single-ascending-dose study was to determine the safety and tolerability of intranasal dexmedetomidine in the elderly. We randomly assigned 48 surgical patients ≥65 yr of age to receive single intranasal doses of dexmedetomidine or placebo (5:1 ratio) in four sequential dose cohorts: 0.5, 1.0, 1.5, and 2.0 μg kg One subject (1.0 μg kg Intranasal dexmedetomidine in elderly subjects had a sedative effect, but caused a high incidence of profound and sustained hypotension irrespective of β-blocker use. The technique is unsuitable for routine clinical use. NTR5513 (The Netherlands Trial Registry 5513).
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this double-blind, placebo-controlled, single-ascending-dose study was to determine the safety and tolerability of intranasal dexmedetomidine in the elderly.
METHODS
METHODS
We randomly assigned 48 surgical patients ≥65 yr of age to receive single intranasal doses of dexmedetomidine or placebo (5:1 ratio) in four sequential dose cohorts: 0.5, 1.0, 1.5, and 2.0 μg kg
RESULTS
RESULTS
One subject (1.0 μg kg
CONCLUSIONS
CONCLUSIONS
Intranasal dexmedetomidine in elderly subjects had a sedative effect, but caused a high incidence of profound and sustained hypotension irrespective of β-blocker use. The technique is unsuitable for routine clinical use.
CLINICAL TRIAL REGISTRATION
BACKGROUND
NTR5513 (The Netherlands Trial Registry 5513).
Identifiants
pubmed: 32029262
pii: S0007-0912(19)31015-3
doi: 10.1016/j.bja.2019.12.025
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.