Associations between changes in oxygenation, dead space and driving pressure induced by the first prone position session and mortality in patients with acute respiratory distress syndrome.
Acute respiratory distress syndrome (ARDS)
PaO2/FiO2
VD/VT
dead space
driving pressure
mortality
oxygenation
prognostication
prone position (PP)
refractory hypoxemia
respiratory system driving pressure
ΔP
ΔPRS
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
8
2
2020
pubmed:
8
2
2020
medline:
8
2
2020
Statut:
ppublish
Résumé
Outcome prediction in acute respiratory distress syndrome (ARDS) is challenging, especially in patients with severe hypoxemia. The aim of the current study was to determine the prognostic capacity of changes in PaO This was a post hoc analysis of the conveniently-sized 'Molecular Diagnosis and Risk Stratification of Sepsis' study (MARS). The current analysis included ARDS patients who were placed in the PP. The primary endpoint was the prognostic capacity of the PP-induced changes in PaO Ninety patients were included; 28-day mortality was 46%. PP-induced changes in PaO Changes in PaO
Sections du résumé
BACKGROUND
BACKGROUND
Outcome prediction in acute respiratory distress syndrome (ARDS) is challenging, especially in patients with severe hypoxemia. The aim of the current study was to determine the prognostic capacity of changes in PaO
METHODS
METHODS
This was a post hoc analysis of the conveniently-sized 'Molecular Diagnosis and Risk Stratification of Sepsis' study (MARS). The current analysis included ARDS patients who were placed in the PP. The primary endpoint was the prognostic capacity of the PP-induced changes in PaO
RESULTS
RESULTS
Ninety patients were included; 28-day mortality was 46%. PP-induced changes in PaO
CONCLUSIONS
CONCLUSIONS
Changes in PaO
Identifiants
pubmed: 32030216
doi: 10.21037/jtd.2019.12.38
pii: jtd-11-12-5004
pmc: PMC6987992
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5004-5013Commentaires et corrections
Type : CommentIn
Informations de copyright
2019 Journal of Thoracic Disease. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
Références
N Engl J Med. 1998 Feb 5;338(6):347-54
pubmed: 9449727
Cancer. 1950 Jan;3(1):32-5
pubmed: 15405679
JAMA. 2016 Feb 23;315(8):788-800
pubmed: 26903337
Am J Respir Crit Care Med. 2014 Feb 15;189(4):494-6
pubmed: 24528322
Crit Care Med. 2003 Dec;31(12):2727-33
pubmed: 14668608
Am J Respir Crit Care Med. 1998 Feb;157(2):387-93
pubmed: 9476848
Intensive Care Med. 2016 Dec;42(12):1865-1876
pubmed: 27757516
Crit Care Med. 2013 Oct;41(10):2373-8
pubmed: 23921277
Chest. 2008 Jan;133(1):62-71
pubmed: 17989165
N Engl J Med. 2013 Sep 5;369(10):980-1
pubmed: 24004127
Intensive Care Med. 2013 Nov;39(11):1909-15
pubmed: 24026295
Intensive Care Med. 2019 Sep;45(9):1321-1323
pubmed: 31101961
Crit Care. 2010;14(1):R1
pubmed: 20055989
J Clin Epidemiol. 1996 Dec;49(12):1373-9
pubmed: 8970487
Lancet Respir Med. 2016 Apr;4(4):272-80
pubmed: 26947624
Intensive Care Med. 2014 Mar;40(3):332-41
pubmed: 24435203
Respir Care. 2010 Dec;55(12):1705-16
pubmed: 21122180
N Engl J Med. 2000 May 4;342(18):1301-8
pubmed: 10793162
Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S280-S288
pubmed: 29068269
Intensive Care Med. 2015 Nov;41(11):2004-5
pubmed: 26202043
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
Respir Care. 2014 Nov;59(11):1611-8
pubmed: 24381187
Crit Care. 2017 Aug 4;21(1):199
pubmed: 28774316
N Engl J Med. 2002 Apr 25;346(17):1281-6
pubmed: 11973365
Ann Intensive Care. 2016 Dec;6(1):89
pubmed: 27638132
Respir Care. 2010 Mar;55(3):282-7
pubmed: 20196876
JAMA. 2017 Oct 10;318(14):1335-1345
pubmed: 28973363
Intensive Care Med. 2018 Jan;44(1):22-37
pubmed: 29218379
Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24
pubmed: 7509706
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Caspian J Intern Med. 2013 Spring;4(2):627-35
pubmed: 24009950
JAMA. 2015 Oct 20;314(15):1637-8
pubmed: 26501539
N Engl J Med. 2015 Feb 19;372(8):747-55
pubmed: 25693014
N Engl J Med. 2001 Aug 23;345(8):568-73
pubmed: 11529210
Intensive Care Med. 2011 Feb;37(2):366-7
pubmed: 21069288