Executive functioning but not IQ or illness severity predicts occupational status in bipolar disorder.
Bipolar disorder
Cognitive dysfunction
Employment
Executive function
Neuropsychological tests
Observational study
Journal
International journal of bipolar disorders
ISSN: 2194-7511
Titre abrégé: Int J Bipolar Disord
Pays: Germany
ID NLM: 101622983
Informations de publication
Date de publication:
07 Feb 2020
07 Feb 2020
Historique:
received:
14
08
2019
accepted:
05
11
2019
entrez:
8
2
2020
pubmed:
8
2
2020
medline:
8
2
2020
Statut:
epublish
Résumé
Bipolar disorder is associated with significant functional deficits including occupational functioning. Despite the high rates of unemployment and sick leave in the patient population, only a limited number of studies have examined factors associated with occupational functioning in bipolar disorder. The aim of the study was to investigate the relative importance of demographic, clinical, and neuropsychological factors on occupational dysfunction in bipolar disorder. A sample of 120 partially or fully remitted bipolar disorder I and II patients were included in the study. Patients were stratified into an active and an inactive group based on the number of hours per week working or studying. Active (n = 86) and inactive (n = 34) patients were compared with respect to demographic factors, clinical characteristics, medication, measures of psychosocial functioning, and cognitive functioning (i.e., IQ and executive functions). No other cognitive domains were examined. Univariate analyses revealed better overall cognitive function in active patients in terms of IQ and executive functioning. However, only executive functioning accounted for a significant amount of the variance in occupational status when other significant predictors were taken into account. Executive functioning was a more powerful predictor of occupational status in bipolar disorder patients than IQ and other clinical factors, including illness severity.
Sections du résumé
BACKGROUND
BACKGROUND
Bipolar disorder is associated with significant functional deficits including occupational functioning. Despite the high rates of unemployment and sick leave in the patient population, only a limited number of studies have examined factors associated with occupational functioning in bipolar disorder. The aim of the study was to investigate the relative importance of demographic, clinical, and neuropsychological factors on occupational dysfunction in bipolar disorder.
METHODS
METHODS
A sample of 120 partially or fully remitted bipolar disorder I and II patients were included in the study. Patients were stratified into an active and an inactive group based on the number of hours per week working or studying. Active (n = 86) and inactive (n = 34) patients were compared with respect to demographic factors, clinical characteristics, medication, measures of psychosocial functioning, and cognitive functioning (i.e., IQ and executive functions). No other cognitive domains were examined.
RESULTS
RESULTS
Univariate analyses revealed better overall cognitive function in active patients in terms of IQ and executive functioning. However, only executive functioning accounted for a significant amount of the variance in occupational status when other significant predictors were taken into account.
CONCLUSIONS
CONCLUSIONS
Executive functioning was a more powerful predictor of occupational status in bipolar disorder patients than IQ and other clinical factors, including illness severity.
Identifiants
pubmed: 32030544
doi: 10.1186/s40345-019-0168-6
pii: 10.1186/s40345-019-0168-6
pmc: PMC7005229
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Subventions
Organisme : Vetenskapsrådet
ID : 2018-02653
Organisme : Swedish Federal Government
ID : ALF 20170019
Organisme : Swedish Federal Government
ID : ALFGBG-716801
Références
J Affect Disord. 2012 Feb;136(3):812-8
pubmed: 22129770
Bipolar Disord. 2005 Jun;7(3):286-91
pubmed: 15898967
Arch Clin Neuropsychol. 2010 May;25(3):157-73
pubmed: 20197297
J Pers Soc Psychol. 2004 Jan;86(1):162-73
pubmed: 14717634
J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):377-405
pubmed: 12426407
Acta Psychiatr Scand. 2009 Sep;120(3):239-46
pubmed: 19426162
Addiction. 1993 Jun;88(6):791-804
pubmed: 8329970
Eur Psychiatry. 2010 Oct;25(6):338-44
pubmed: 20435449
Arch Gen Psychiatry. 2002 Jun;59(6):530-7
pubmed: 12044195
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Psychopathology. 2009;42(3):148-56
pubmed: 19276630
Acta Psychiatr Scand. 2010 Dec;122(6):507-15
pubmed: 20712826
Bipolar Disord. 2007 Feb-Mar;9(1-2):45-52
pubmed: 17391349
Bipolar Disord. 2007 Feb-Mar;9(1-2):103-13
pubmed: 17391354
Prog Neuropsychopharmacol. 1979;3(4):405-12
pubmed: 400996
J Clin Psychiatry. 2007 Jul;68(7):1078-86
pubmed: 17685745
Bipolar Disord. 2009 Jun;11(4):391-400
pubmed: 19500092
PLoS One. 2015 Jan 23;10(1):e0115562
pubmed: 25614986
Psychol Sci. 2006 Feb;17(2):172-9
pubmed: 16466426
Curr Psychiatry Rep. 2017 Jan;19(1):3
pubmed: 28097635
Br J Psychiatry. 1978 Nov;133:429-35
pubmed: 728692
Psychiatry Res. 2011 Apr 30;186(2-3):254-60
pubmed: 20647154
Bipolar Disord. 2010 Nov;12(7):720-6
pubmed: 21040289
Arch Gen Psychiatry. 1990 Dec;47(12):1106-11
pubmed: 2244795
Bipolar Disord. 2015 Dec;17 Suppl 2:41-55
pubmed: 26688289
J Affect Disord. 2010 Feb;121(1-2):156-60
pubmed: 19505727
Am J Psychiatry. 2000 Feb;157(2):220-8
pubmed: 10671390
Eur Arch Psychiatry Clin Neurosci. 2014 Apr;264(3):247-54
pubmed: 23912643
Psychiatr Serv. 2004 Jan;55(1):54-8
pubmed: 14699201
Psychiatry Res. 2013 Dec 15;210(2):472-8
pubmed: 23870493
Eur Addict Res. 2005;11(1):22-31
pubmed: 15608468
Biol Psychiatry. 2003 Jun 1;53(11):1028-42
pubmed: 12788248
Soc Psychiatry Psychiatr Epidemiol. 2013 Oct;48(10):1601-10
pubmed: 23754681
J Neural Transm (Vienna). 2009 Dec;116(12):1667-74
pubmed: 19756368
Acta Psychiatr Scand. 2000 May;101(5):374-81
pubmed: 10823297
Bull Menninger Clin. 1975 Sep;39(5):448-80
pubmed: 1182328
J Clin Psychiatry. 2008 May;69(5):712-9
pubmed: 18435565
Am J Psychiatry. 1995 Mar;152(3):379-84
pubmed: 7864263
J Affect Disord. 2006 Jul;93(1-3):105-15
pubmed: 16677713
Acta Psychiatr Scand. 2001 Mar;103(3):163-70
pubmed: 11240572
BMC Psychiatry. 2013 Jun 07;13:165
pubmed: 23758923
Lancet. 1997 May 24;349(9064):1498-504
pubmed: 9167458
Acta Psychiatr Scand. 2010 Dec;122(6):499-506
pubmed: 20637012
Int J Bipolar Disord. 2019 Jun 28;7(1):14
pubmed: 31250342
J Affect Disord. 2013 Feb 20;145(2):156-64
pubmed: 22877965
J Affect Disord. 2017 Jun;215:135-142
pubmed: 28319690