Visual Dysfunction of the Superior Colliculus in De Novo Parkinsonian Patients.
Adult
Aged
Case-Control Studies
Contrast Sensitivity
Female
Functional Neuroimaging
Geniculate Bodies
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson Disease
/ diagnostic imaging
Photic Stimulation
Superior Colliculi
/ diagnostic imaging
Visual Cortex
/ diagnostic imaging
Visual Pathways
/ diagnostic imaging
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
07
2019
revised:
05
02
2020
accepted:
05
02
2020
pubmed:
8
2
2020
medline:
28
7
2020
entrez:
8
2
2020
Statut:
ppublish
Résumé
The dual hit hypothesis about the pathogenesis of Parkinson disease (PD) suggests that the brainstem is a convergent area for the propagation of pathological α-synuclein from the periphery to the brain. Although brainstem structures are likely to be affected early in the course of the disease, detailed information regarding specific brainstem regions is lacking. The aim of our study was to investigate the function of the superior colliculus, a sensorimotor brainstem structure, in de novo PD patients compared to controls using brain functional magnetic imaging and visual stimulation paradigms. De novo PD patients and controls were recruited. PD subjects were imaged before and after starting PD medications. A recently developed functional magnetic resonance imaging protocol was used to stimulate and visualize the superior colliculus and 2 other visual structures: the lateral geniculate nucleus and the primary visual cortex. In the 22 PD patients, there was no modulation of the superior colliculus responses to the luminance contrasts compared to controls. This implies a hypersensitivity to low luminance contrast and abnormal rapid blood oxygenation level-dependent signal saturation to high luminance contrasts. The lateral geniculate nucleus was only modulated by 3 to 9% luminance contrasts compared to controls. No major differences were found in the primary visual cortex between both groups. Our findings suggest that pathological superior colliculus visual responses in de novo PD patients are present early in the course of the disease. Changes in imaging the superior colliculus could play an important role as a preclinical biomarker of the disease. ANN NEUROL 2020;87:533-546.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-546Informations de copyright
© 2020 American Neurological Association.
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