Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
19
09
2019
accepted:
04
12
2019
pubmed:
8
2
2020
medline:
2
9
2020
entrez:
8
2
2020
Statut:
ppublish
Résumé
Insulinlike growth factor II (IGF-II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF-II levels and obesity. This study assessed the relationship between serum IGF-II levels and BMI and determined whether IGF-II levels predict weight gain. Serum samples were available from 911 American Indians with a recorded BMI. IGF-II was measured using enzyme-linked immunosorbent assay. Serum IGF-II levels were negatively correlated with BMI (r = -0.17, P = 4.4 × 10 There is a negative relationship between IGF-II levels and BMI, in which the correlation is stronger at older ages. The association between genetic risk for BMI and IGF-II levels suggests that this correlation may be due to an effect of obesity on IGF-II.
Identifiants
pubmed: 32030914
doi: 10.1002/oby.22741
pmc: PMC7192225
mid: NIHMS1547056
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
676-682Subventions
Organisme : Intramural NIH HHS
ID : Z01 DK069071
Pays : United States
Organisme : NIDDK NIH HHS
ID : the intramural research programme of the National
Pays : United States
Informations de copyright
Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
Références
Diabetes Metab Res Rev. 2017 May;33(4):
pubmed: 27862917
Metabolism. 1995 Oct;44(10 Suppl 4):37-44
pubmed: 7476310
Physiol Behav. 1987;40(6):755-8
pubmed: 3313450
Diabetes. 2017 Aug;66(8):2284-2295
pubmed: 28476931
Int J Epidemiol. 2013 Aug;42(4):1134-44
pubmed: 24062299
Trends Neurosci. 1988 Mar;11(3):107-11
pubmed: 2465607
Am J Epidemiol. 2001 Sep 15;154(6):504-13
pubmed: 11549555
Endocrinology. 1995 Dec;136(12):5718-24
pubmed: 7588328
Neuroendocrinology. 1992 Aug;56(2):161-8
pubmed: 1407369
Circ Cardiovasc Genet. 2017 Dec;10(6):
pubmed: 29237685
Genet Epidemiol. 2008 Sep;32(6):567-73
pubmed: 18425821
Hum Mol Genet. 2001 Apr 1;10(8):807-14
pubmed: 11285246
Growth Horm IGF Res. 1998 Jun;8(3):183-4
pubmed: 10984305
J Endocrinol. 1994 Dec;143(3):433-9
pubmed: 7836887
Mol Endocrinol. 1989 Aug;3(8):1263-9
pubmed: 2779582
Int J Obes Relat Metab Disord. 1997 Sep;21(9):822-5
pubmed: 9376897
Hum Mol Genet. 2001 Jul 1;10(14):1491-501
pubmed: 11448941
Diabetes Metab Rev. 1990 Feb;6(1):1-27
pubmed: 2192853
Am J Hum Genet. 1998 May;62(5):1198-211
pubmed: 9545414
Cancer Epidemiol Biomarkers Prev. 2002 Aug;11(8):758-66
pubmed: 12163330
Metabolism. 2002 Apr;51(4):451-6
pubmed: 11912552
Obesity (Silver Spring). 2019 May;27(5):845-854
pubmed: 30887699
Diabetes Care. 1997 Jul;20(7):1183-97
pubmed: 9203460
Epidemiology. 2014 May;25(3):427-35
pubmed: 24681576
Nat Genet. 2001 Feb;27(2):195-200
pubmed: 11175789
Am J Hum Genet. 2011 Feb 11;88(2):173-82
pubmed: 21310274
Diabetes. 2003 Jun;52(6):1403-8
pubmed: 12765950
Endocr Rev. 1995 Feb;16(1):3-34
pubmed: 7758431