Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems.
Administration, Oral
Animals
Antimalarials
/ administration & dosage
Biological Availability
Drug Compounding
/ methods
Drug Delivery Systems
/ methods
Drug Stability
Emulsions
Excipients
/ chemistry
Male
Molecular Structure
Polyethylene Glycols
/ chemistry
Polyvinyls
/ chemistry
Prodrugs
/ administration & dosage
Quinolones
/ administration & dosage
Rats, Sprague-Dawley
Solubility
Antimalarial drugs
amorphous form
oral bioavailability
self-emulsifying drug delivery systems (SEDDS)
spray-dried dispersions (SDD)
Journal
Pharmaceutical development and technology
ISSN: 1097-9867
Titre abrégé: Pharm Dev Technol
Pays: England
ID NLM: 9610932
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
8
2
2020
medline:
15
1
2021
entrez:
8
2
2020
Statut:
ppublish
Résumé
To improve the solubility and oral bioavailability of a novel antimalarial agent ELQ-331(a prodrug of ELQ-300), spray-dried dispersions (SDD) and a self-emulsifying drug delivery system (SEDDS) were developed. SDD were prepared with polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus
Identifiants
pubmed: 32031478
doi: 10.1080/10837450.2020.1725893
pmc: PMC8120996
mid: NIHMS1693132
doi:
Substances chimiques
6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
0
Antimalarials
0
Emulsions
0
Excipients
0
Polyvinyls
0
Prodrugs
0
Quinolones
0
polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-639Subventions
Organisme : BLRD VA
ID : IK6 BX004857
Pays : United States
Organisme : BLRD VA
ID : I01 BX003312
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI100569
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141412
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100569
Pays : United States
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