Triggered Release of Loads from Microcapsule-in-Microcapsule Hydrogel Microcarriers: En-Route to an "Artificial Pancreas".
Cadmium Compounds
/ chemistry
Calcium Carbonate
/ chemistry
Capsules
/ chemistry
DNA, Catalytic
/ chemistry
Dextrans
/ chemistry
Drug Carriers
/ chemistry
Drug Liberation
Fluorescent Dyes
/ chemistry
Glucose
/ chemistry
Glucose Oxidase
/ chemistry
Hydrogels
/ chemistry
Insulin
/ chemistry
Pancreas, Artificial
Quantum Dots
/ chemistry
Rhodamines
/ chemistry
Selenium Compounds
/ chemistry
Sulfides
/ chemistry
Zinc Compounds
/ chemistry
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
pubmed:
8
2
2020
medline:
20
4
2021
entrez:
8
2
2020
Statut:
ppublish
Résumé
A method to assemble stimuli-responsive nucleic acid-based hydrogel-stabilized microcapsule-in-microcapsule systems is introduced. An inner aqueous compartment stabilized by a stimuli-responsive hydrogel-layer (∼150 nm) provides the inner microcapsule (diameter ∼2.5 μm). The inner microcapsule is separated from an outer aqueous compartment stabilized by an outer stimuli-responsive hydrogel layer (thickness of ∼150 nm) that yields the microcapsule-in-microcapsule system. Different loads, e.g., tetramethyl rhodamine-dextran (TMR-D) and CdSe/ZnS quantum dots (QDs), are loaded in the inner and outer aqueous compartments. The hydrogel layers exist in a higher stiffness state that prevents inter-reservoir or leakage of the loads from the respective aqueous compartments. Subjecting the inner hydrogel layer to Zn
Identifiants
pubmed: 32031792
doi: 10.1021/jacs.9b11847
pmc: PMC7467680
doi:
Substances chimiques
Cadmium Compounds
0
Capsules
0
DNA, Catalytic
0
Dextrans
0
Drug Carriers
0
Fluorescent Dyes
0
Fluoro-Ruby
0
Hydrogels
0
Insulin
0
Rhodamines
0
Selenium Compounds
0
Sulfides
0
Zinc Compounds
0
cadmium selenide
A7F646JC5C
Glucose Oxidase
EC 1.1.3.4
Calcium Carbonate
H0G9379FGK
Glucose
IY9XDZ35W2
zinc sulfide
KPS085631O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4223-4234Références
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