Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.
ERK
MAPK signaling
MEK
Ras
actin
cancer
cell confinement
cell mechanics
mitosis
mitotic rounding
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
09 03 2020
09 03 2020
Historique:
received:
08
03
2019
revised:
30
09
2019
accepted:
06
01
2020
pubmed:
8
2
2020
medline:
23
10
2020
entrez:
8
2
2020
Statut:
ppublish
Résumé
To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We found that short-term induction of oncogenic Ras
Identifiants
pubmed: 32032547
pii: S1534-5807(20)30005-8
doi: 10.1016/j.devcel.2020.01.004
pmc: PMC7063569
pii:
doi:
Substances chimiques
ras Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
563-573.e3Subventions
Organisme : Cancer Research UK
ID : 17343
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_CF12266
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 9786
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R009732/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1529/A23335
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 5369923
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1529/A17343
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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