Levan-based hydrogels for controlled release of Amphotericin B for dermal local antifungal therapy of Candidiasis.
Amphotericin B
/ administration & dosage
Animals
Antifungal Agents
/ administration & dosage
Candida albicans
/ drug effects
Candidiasis
/ drug therapy
Cell Line
Delayed-Action Preparations
/ administration & dosage
Drug Liberation
/ drug effects
Fructans
/ administration & dosage
Hydrogels
/ administration & dosage
Mice
Amphotericin B
Antifungal activity
Controlled drug release
Halomonas Levan
Hydrogel
Wound healing
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
30 Mar 2020
30 Mar 2020
Historique:
received:
03
10
2019
revised:
13
01
2020
accepted:
03
02
2020
pubmed:
8
2
2020
medline:
26
11
2020
entrez:
8
2
2020
Statut:
ppublish
Résumé
Hydrogels from Halomonas levan polysaccharide were prepared at different crosslinking densities. Swelling results demonstrated pH dependent rather than temperature dependent swelling of the hydrogel and the highest swelling value was achieved at basic conditions with a swelling ratio of 9.1 ± 0.1 which is the highest reported for levan based hydrogels. SEM images show a porous network architecture, which indicates a large surface area of the hydrogels. Rheological analyses showed the viscoelastic behavior of the hydrogels. Biocompatibility of the hydrogels was confirmed by cell culture experiments. For drug release experiments Amphotericin B (AmB) was used. 51% of the loaded AmB was released into the PBS buffer and the released AmB had a significant antifungal activity against Candida albicans.
Identifiants
pubmed: 32032777
pii: S0928-0987(20)30044-0
doi: 10.1016/j.ejps.2020.105255
pii:
doi:
Substances chimiques
Antifungal Agents
0
Delayed-Action Preparations
0
Fructans
0
Hydrogels
0
Amphotericin B
7XU7A7DROE
levan
9013-95-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105255Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.