Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells.
biogenesis
breast cancer stem cells
long non-coding RNA
microRNA
targets
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Feb 2020
04 Feb 2020
Historique:
received:
26
12
2019
revised:
27
01
2020
accepted:
02
02
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
9
2
2020
Statut:
epublish
Résumé
Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a product generated from erroneous transcription. Even though understanding of biological and molecular functions of noncoding RNA remains enigmatic, researchers have established the pivotal role of these RNAs in governing a plethora of biological phenomena that includes cancer-associated cellular processes such as proliferation, invasion, migration, apoptosis, and stemness. In addition to this, the transmission of microRNAs and long non-coding RNAs was identified as a source of communication to breast cancer cells either locally or systemically. The present review provides in-depth information with an aim at discovering the fundamental potential of non-coding RNAs, by providing knowledge of biogenesis and functional roles of micro RNA and long non-coding RNAs in breast cancer and breast cancer stem cells, as either oncogenic drivers or tumor suppressors. Furthermore, non-coding RNAs and their potential role as diagnostic and therapeutic moieties have also been summarized.
Identifiants
pubmed: 32033146
pii: cancers12020351
doi: 10.3390/cancers12020351
pmc: PMC7072613
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Hamad Medical Corporation
ID : 16354/16
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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