Isolation of an Anti-Tumour Disintegrin: Dabmaurin-1, a Peptide Lebein-1-Like, from
Amino Acid Sequence
Angiogenesis Inhibitors
/ chemistry
Animals
Cell Adhesion
/ drug effects
Cell Line
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Disintegrins
/ chemistry
Dose-Response Relationship, Drug
Endothelial Cells
/ drug effects
Extracellular Matrix
/ drug effects
Humans
Neovascularization, Pathologic
/ pathology
Viper Venoms
/ chemistry
Viperidae
angiogenesis
anti–angiogenic peptide
anti–tumour
cell adhesion molecules
disintegrin
endothelial cells
integrin
snake venom
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
received:
03
01
2020
revised:
28
01
2020
accepted:
31
01
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
23
2
2021
Statut:
epublish
Résumé
In the soft treatment of cancer tumours, consequent downregulation of the malignant tissue angiogenesis constitutes an efficient way to stifle tumour development and metastasis spreading. As angiogenesis requires integrin-promoting endothelial cell adhesion, migration, and vessel tube formation, integrins represent potential targets of new therapeutic anti-angiogenic agents. Our work is a contribution to the research of such therapeutic disintegrins in animal venoms. We report isolation of one peptide, named Dabmaurin-1, from the hemotoxic venom of snake
Identifiants
pubmed: 32033352
pii: toxins12020102
doi: 10.3390/toxins12020102
pmc: PMC7076848
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Disintegrins
0
Viper Venoms
0
lebein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
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