Glucose as a Major Antioxidant: When, What for and Why It Fails?
NADPH
glucose
glycogen
glycolysis
insulin resistance
pentose phosphate pathway
redox balance
stress resistance
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
05 Feb 2020
05 Feb 2020
Historique:
received:
10
12
2019
revised:
01
02
2020
accepted:
03
02
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
9
2
2020
Statut:
epublish
Résumé
A human organism depends on stable glucose blood levels in order to maintain its metabolic needs. Glucose is considered to be the most important energy source, and glycolysis is postulated as a backbone pathway. However, when the glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of the pentose phosphate pathway (PPP) glucose is essential and cannot be substituted by other metabolites. The PPP generates and maintains the levels of nicotinamide adenine dinucleotide phosphate (NADPH) needed for the reduction in oxidized glutathione and protein thiols, the synthesis of lipids and DNA as well as for xenobiotic detoxification, regulatory redox signaling and counteracting infections. The flux of glucose into a PPP-particularly under extreme oxidative and toxic challenges-is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP
Identifiants
pubmed: 32033390
pii: antiox9020140
doi: 10.3390/antiox9020140
pmc: PMC7070274
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Lipid Res. 2019 Oct;60(10):1648-1684
pubmed: 31209153
Mol Cell. 2015 Aug 20;59(4):519-21
pubmed: 26295959
Arch Physiol Biochem. 2018 Jul;124(3):275-285
pubmed: 29105496
Int J Mol Sci. 2016 Sep 29;17(10):
pubmed: 27690013
Redox Biol. 2017 Oct;13:646-654
pubmed: 28818793
Front Horm Res. 2014;42:1-28
pubmed: 24732922
J Biol Chem. 2004 Sep 17;279(38):39846-55
pubmed: 15247300
Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1343-51
pubmed: 22395109
BMC Biol. 2017 Apr 10;15(1):30
pubmed: 28395669
Georgian Med News. 2019 Apr;(289):68-72
pubmed: 31215882
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2791-E2800
pubmed: 29511104
Nat Rev Endocrinol. 2018 Jul;14(7):404-414
pubmed: 29773871
Med Hypotheses. 2014 Mar;82(3):387-9
pubmed: 24495563
Am J Physiol Cell Physiol. 2015 Jul 15;309(2):C92-6
pubmed: 26017147
J Diabetes Investig. 2016 Apr;7 Suppl 1:50-5
pubmed: 27186356
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
Pharmacol Ther. 2017 Nov;179:17-30
pubmed: 28527919
J Neurochem. 1983 Nov;41(5):1253-60
pubmed: 6619864
J Biol Chem. 2008 Nov 21;283(47):32492-9
pubmed: 18809674
Nat Commun. 2016 Mar 15;7:10894
pubmed: 26976705
Ups J Med Sci. 2016 May;121(2):120-32
pubmed: 27044660
Redox Biol. 2017 Aug;12:727-732
pubmed: 28411557
Neurochem Res. 1996 Sep;21(9):1005-12
pubmed: 8897463
Methods Mol Biol. 2019;1890:61-76
pubmed: 30414145
Biochem J. 2013 Mar 15;450(3):595-605
pubmed: 23282133
Enzyme. 1991;45(4):180-7
pubmed: 1823863
Nat Commun. 2019 Jan 11;10(1):139
pubmed: 30635569
J Neurotrauma. 2005 Oct;22(10):1052-65
pubmed: 16238483
Cells. 2019 Jul 30;8(8):
pubmed: 31366062
Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E273-E283
pubmed: 28512154
J Insect Physiol. 2015 Aug;79:42-54
pubmed: 26050918
IUBMB Life. 2012 May;64(5):362-9
pubmed: 22431005
Antioxid Redox Signal. 2017 Apr 1;26(10):501-518
pubmed: 27225690
Cell. 2016 Apr 7;165(2):343-56
pubmed: 26997483
Curr Pharm Des. 2019;25(16):1889-1912
pubmed: 31267859
Circulation. 2016 Mar 15;133(11):1104-14
pubmed: 26976915
Free Radic Biol Med. 2019 Dec 30;:
pubmed: 31899344
Atherosclerosis. 2016 Apr;247:225-82
pubmed: 26967715
J Biol Chem. 2017 Oct 13;292(41):17113-17120
pubmed: 28848047
Metabolism. 2013 May;62(5):622-33
pubmed: 23260798
Endocr J. 2017 Apr 29;64(4):375-378
pubmed: 28321033
Redox Biol. 2019 Oct;27:101159
pubmed: 30902504
Hematol Oncol Clin North Am. 2016 Apr;30(2):373-93
pubmed: 27040960
Antioxidants (Basel). 2018 Sep 03;7(9):
pubmed: 30177630
Cell Metab. 2017 Oct 3;26(4):585-587
pubmed: 28978421
Mol Cell. 2015 Aug 6;59(3):359-71
pubmed: 26190262
Oxid Med Cell Longev. 2017;2017:9175806
pubmed: 28808499
Mol Aspects Med. 2003 Aug-Oct;24(4-5):281-91
pubmed: 12893006
Nature. 2014 Jun 12;510(7504):298-302
pubmed: 24805240
Early Hum Dev. 2015 Nov;91(11):629-35
pubmed: 26375355
Science. 2017 May 5;356(6337):513-519
pubmed: 28473584
Can J Diabetes. 2018 Apr;42 Suppl 1:S104-S108
pubmed: 29650081
PLoS Comput Biol. 2017 Sep 28;13(9):e1005758
pubmed: 28957320
Nature. 2018 Jul;559(7715):637-641
pubmed: 30022161
Elife. 2017 Oct 24;6:
pubmed: 29063832
Blood. 2009 Feb 26;113(9):2118-9
pubmed: 19246566
Redox Biol. 2017 Apr;11:482-501
pubmed: 28086196
Ann Hematol. 2017 May;96(5):839-845
pubmed: 28197721
Antioxid Redox Signal. 2018 Jan 20;28(3):251-272
pubmed: 28648096
Diabetologia. 2018 Oct;61(10):2108-2117
pubmed: 30132036
Free Radic Biol Med. 2017 Dec;113:16-25
pubmed: 28917508
Nat Cell Biol. 2019 Feb;21(2):143-151
pubmed: 30602724
Nat Rev Mol Cell Biol. 2018 Oct;19(10):617
pubmed: 30061710
Oxid Med Cell Longev. 2019 Feb 19;2019:1472623
pubmed: 30915194
Nature. 2019 Sep;573(7772):135-138
pubmed: 31462774
Free Radic Res. 2018 Feb;52(2):135-149
pubmed: 29251014
Curr Drug Targets. 2015;16(1):13-9
pubmed: 25585126
Aging Dis. 2013 Oct 21;5(1):52-62
pubmed: 24490117
Animal Model Exp Med. 2018 Mar;1(1):7-13
pubmed: 29863179
EMBO J. 1995 Nov 1;14(21):5209-15
pubmed: 7489710
Pediatrics. 2019 Apr;143(4):
pubmed: 30910915
Cell Metab. 2007 Oct;6(4):280-93
pubmed: 17908557
Free Radic Res. 2016 Oct;50(10):1047-1064
pubmed: 27684214
Lancet. 2017 Nov 4;390(10107):2050-2062
pubmed: 28864332
Cell Metab. 2017 Jul 5;26(1):17-23
pubmed: 28683284
Nat Rev Cardiol. 2020 Mar;17(3):170-194
pubmed: 31591535
Diabetologia. 2018 Oct;61(10):2098-2107
pubmed: 30132034
Redox Biol. 2017 Apr;11:502-515
pubmed: 28086197
Mol Cell. 2015 Oct 15;60(2):195-207
pubmed: 26474064
Biochimie. 2019 May;160:156-171
pubmed: 30878492
Lifestyle Genom. 2018;11(1):9-12
pubmed: 30001536
Annu Rev Biochem. 2017 Jun 20;86:245-275
pubmed: 28301739
Q Rev Biol. 2015 Sep;90(3):251-68
pubmed: 26591850
Diabetes Obes Metab. 2014 Sep;16 Suppl 1:87-95
pubmed: 25200301
Cell Metab. 2017 Jun 6;25(6):1231-1242
pubmed: 28591631
Redox Biol. 2015 Aug;5:301-307
pubmed: 26092779
Croat Med J. 2016 Apr 23;57(2):141-9
pubmed: 27106356
J Biol Chem. 2014 May 2;289(18):12189-94
pubmed: 24637025
Nat Cell Biol. 2009 Jun;11(6):747-52
pubmed: 19448625
Genes Cancer. 2013 Mar;4(3-4):135-47
pubmed: 24020005
Trends Biochem Sci. 2014 Apr;39(4):199-218
pubmed: 24647116
Plant Foods Hum Nutr. 2016 Jun;71(2):129-36
pubmed: 27184000
Nat Commun. 2017 Jun 19;8:15868
pubmed: 28627510
Redox Biol. 2015 Dec;6:51-72
pubmed: 26184557
Analyst. 2019 Mar 25;144(7):2367-2374
pubmed: 30793720
Cell. 2018 Jan 11;172(1-2):234-248.e17
pubmed: 29307489
Diabetes Obes Metab. 2018 Feb;20 Suppl 1:5-21
pubmed: 29364588
J Allergy Clin Immunol. 2017 Jan;139(1):212-219.e3
pubmed: 27458052
Science. 2017 Feb 17;355(6326):733-735
pubmed: 28209896
Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E11-21
pubmed: 18840763
Nat Med. 2017 Dec;23(12):1444-1453
pubmed: 29106398
Med Hypotheses. 2016 Oct;95:77-81
pubmed: 27692173
Cell. 2016 Apr 21;165(3):566-79
pubmed: 27087445
Cardiovasc Diabetol. 2016 Jun 01;15:82
pubmed: 27245224
Free Radic Biol Med. 2020 Jan 15;:
pubmed: 31953150
Horm Metab Res. 1991 Apr;23(4):171-3
pubmed: 1874475
Mol Genet Metab Rep. 2017 Jun 09;12:69-75
pubmed: 28649515
Worm. 2016 Mar 04;5(2):e1156831
pubmed: 27383221
EMBO J. 2017 Jun 1;36(11):1474-1492
pubmed: 28438892
Cell. 2018 Jan 11;172(1-2):22-40
pubmed: 29328913
Lancet. 2019 Sep 21;394(10203):1041-1054
pubmed: 31443926
Mol Aspects Med. 2015 Dec;46:70-7
pubmed: 26344371
J Biol. 2007 Dec 21;6(4):10
pubmed: 18154684
Drugs. 2019 Feb;79(3):219-230
pubmed: 30701480
Free Radic Biol Med. 2019 Nov 19;:
pubmed: 31756524
Obesity (Silver Spring). 2018 Feb;26(2):254-268
pubmed: 29086496
Cell. 2017 Oct 5;171(2):372-384.e12
pubmed: 28942920
JAMA Intern Med. 2020 Jan 21;:
pubmed: 31961383
Cells. 2018 Dec 27;8(1):
pubmed: 30591661
Physiol Behav. 2016 Oct 1;164(Pt B):432-437
pubmed: 27174610
J Nutr Biochem. 2018 Jul;57:1-13
pubmed: 29529489
Biol Rev Camb Philos Soc. 2015 Aug;90(3):927-63
pubmed: 25243985
Neurochem Int. 2016 Feb;93:26-39
pubmed: 26723542
Pediatr Med Chir. 2017 Jun 28;39(2):155
pubmed: 28673076
Ecotoxicol Environ Saf. 2018 Feb;148:684-692
pubmed: 29172149