Hydrogel Microvalves as Control Elements for Parallelized Enzymatic Cascade Reactions in Microfluidics.
enzyme
hydrogel
microfluidics
parallelization
poly(N-isopropylacrylamide) (PNiPAAm)
polydimethylsiloxane (PDMS)-on-glass
thermoresponsive
valves
Journal
Micromachines
ISSN: 2072-666X
Titre abrégé: Micromachines (Basel)
Pays: Switzerland
ID NLM: 101640903
Informations de publication
Date de publication:
05 Feb 2020
05 Feb 2020
Historique:
received:
17
12
2019
revised:
26
01
2020
accepted:
01
02
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
9
2
2020
Statut:
epublish
Résumé
Compartmentalized microfluidic devices with immobilized catalysts are a valuable tool for overcoming the incompatibility challenge in (bio) catalytic cascade reactions and high-throughput screening of multiple reaction parameters. To achieve flow control in microfluidics, stimuli-responsive hydrogel microvalves were previously introduced. However, an application of this valve concept for the control of multistep reactions was not yet shown. To fill this gap, we show the integration of thermoresponsive poly(
Identifiants
pubmed: 32033413
pii: mi11020167
doi: 10.3390/mi11020167
pmc: PMC7074747
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 1865
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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