Chronic Diabetes Complications: The Need to Move beyond Classical Concepts.
angiopathy
diabetes mellitus
long-term complications
multisystemic disease
neuropathy
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
16
09
2019
revised:
22
11
2019
accepted:
09
01
2020
pubmed:
9
2
2020
medline:
13
8
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
Chronic-diabetes-related complications simultaneously compromise both the micro- and macrovascular trees, with target organs considered as the paradigm of large vessel injury also entailing microangiopathic changes. However, complications independent or partially independent from vascular damage are often overlooked. This includes neuronal dysfunction (e.g., retinal neurodegeneration), interstitial injury (e.g., tubulointerstitial disease), metabolic damage (e.g., in the heart and liver), and nonclassical conditions such as cognitive decline, impaired pulmonary function, or increased risk of cancer. In this scenario, researchers, endocrinologists and primary care physicians should have a holistic view of the disease and pay further attention to all organs and all potential clinical repercussions, which would certainly contribute to a more rational and integrated patient health care.
Identifiants
pubmed: 32033865
pii: S1043-2760(20)30007-2
doi: 10.1016/j.tem.2020.01.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-295Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.