Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable.
Endocrine
Imaging
PTSD
Physiology
SABV
Sex
Journal
Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
18
11
2019
accepted:
06
12
2019
pubmed:
9
2
2020
medline:
28
4
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
Decades of research into the biological mechanisms of posttraumatic stress disorder (PTSD) suggests that chronic activation of the stress response leads to long-lasting changes in the structure and function of the nervous and endocrine systems. While the prevalence of PTSD is twice as high in females as males, little is known about how sex differences in neuroendocrine systems may contribute to PTSD. In response to the paucity of research on sex-related mechanisms, the National Institutes of Health created a policy that asks researchers to consider sex as a biological variable. This review provides an overview of the current understanding of nervous and endocrine dysfunction in PTSD (e.g., neural circuitry, autonomic arousal, hormonal response), highlighting areas where the influence of sex has been characterized and where further research is needed. We also provide recommendations for using the sex-as-a-biological-variable policy to address specific gaps in PTSD neuroscience research.
Identifiants
pubmed: 32033924
pii: S2451-9022(19)30346-5
doi: 10.1016/j.bpsc.2019.12.006
pmc: PMC7150641
mid: NIHMS1547103
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-391Subventions
Organisme : NIMH NIH HHS
ID : R01 MH117292
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH112956
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094757
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH115874
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106595
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD102974
Pays : United States
Organisme : NIMH NIH HHS
ID : K00 MH119603
Pays : United States
Informations de copyright
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Références
Horm Behav. 2012 Sep;62(4):531-8
pubmed: 22986336
Brain Imaging Behav. 2016 Mar;10(1):226-37
pubmed: 25913645
Am J Psychiatry. 2001 Apr;158(4):575-81
pubmed: 11282691
J Anxiety Disord. 2019 Dec;68:102147
pubmed: 31669786
Arch Gen Psychiatry. 1996 May;53(5):380-7
pubmed: 8624181
Int J Psychophysiol. 2009 Sep;73(3):257-64
pubmed: 19374925
Biol Psychiatry. 2018 Feb 1;83(3):244-253
pubmed: 29217296
Psychoneuroendocrinology. 2009 Jun;34(5):687-93
pubmed: 19136216
Psychoneuroendocrinology. 2013 Jun;38(6):808-17
pubmed: 22999654
Br J Psychiatry. 2007 Nov;191:387-92
pubmed: 17978317
Brain Imaging Behav. 2018 Dec 5;:
pubmed: 30519996
Neuroimage Clin. 2016 Oct 10;12:715-723
pubmed: 27761402
Arch Gen Psychiatry. 1995 Dec;52(12):1048-60
pubmed: 7492257
J Consult Clin Psychol. 1998 Dec;66(6):914-23
pubmed: 9874904
Depress Anxiety. 2017 Jan;34(1):51-58
pubmed: 27862643
Biol Psychol. 2017 Oct;129:305-313
pubmed: 28958482
Front Psychiatry. 2014 Jul 21;5:88
pubmed: 25101010
Harv Rev Psychiatry. 2018 Mar/Apr;26(2):57-69
pubmed: 29016379
Lancet Psychiatry. 2015 Nov;2(11):1002-12
pubmed: 26544749
Biol Psychiatry. 2011 Mar 15;69(6):556-63
pubmed: 21035787
J Abnorm Psychol. 2010 Feb;119(1):241-7
pubmed: 20141261
J Psychiatr Res. 2017 Jun;89:14-21
pubmed: 28135632
Behav Res Ther. 2016 Jul;82:28-37
pubmed: 27183343
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15468-73
pubmed: 26621705
Endocrinol Metab Clin North Am. 2013 Sep;42(3):503-13
pubmed: 24011883
Biol Psychol. 2011 Dec;88(2-3):215-22
pubmed: 21856373
Psychosom Med. 2012 Feb-Mar;74(2):153-9
pubmed: 22286850
Soc Cogn Affect Neurosci. 2015 Sep;10(9):1266-72
pubmed: 25688096
Psychosom Med. 2010 Nov;72(9):917-24
pubmed: 20947782
Brain Behav Immun. 2018 Mar;69:203-209
pubmed: 29157934
Am J Med Genet B Neuropsychiatr Genet. 2019 Sep;180(6):415-427
pubmed: 30537437
Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1052-61
pubmed: 17904297
Clin Psychol Rev. 2016 Nov;49:79-91
pubmed: 27623149
Biol Psychiatry. 2018 Feb 1;83(3):254-262
pubmed: 29100627
J Forensic Nurs. 2012 Sep;8(3):122-30
pubmed: 22925127
Psychosom Med. 2001 Jul-Aug;63(4):585-94
pubmed: 11485112
Front Psychol. 2017 Jan 06;7:2031
pubmed: 28111559
Psychiatry Investig. 2013 Jun;10(2):121-30
pubmed: 23798959
J Abnorm Psychol. 1993 Feb;102(1):152-9
pubmed: 8436691
Psychophysiology. 2019 May;56(5):e13329
pubmed: 30672603
Psychosom Med. 2008 Jan;70(1):13-9
pubmed: 17991819
J Abnorm Psychol. 1999 Feb;108(1):134-42
pubmed: 10066999
Depress Anxiety. 2017 Jul;34(7):641-650
pubmed: 28030757
Biol Mood Anxiety Disord. 2012 May 18;2:9
pubmed: 22738125
J Neurosci Res. 2018 Aug;96(8):1388-1397
pubmed: 29741787
Neurobiol Learn Mem. 2014 Sep;113:101-8
pubmed: 24560771
Psychiatry Res. 2013 Dec 30;214(3):260-8
pubmed: 24074963
J Psychiatr Res. 2013 Oct;47(10):1469-78
pubmed: 23827769
Psychoneuroendocrinology. 2015 Jan;51:525-33
pubmed: 25128222
Int J Psychophysiol. 2010 Oct;78(1):27-34
pubmed: 20450940
J Psychiatr Res. 2019 Sep;116:34-41
pubmed: 31181391
Horm Behav. 2015 Nov;76:106-17
pubmed: 25888456
Brain Behav Immun. 2020 Jan;83:260-269
pubmed: 31682970
Biol Psychiatry. 2015 Sep 1;78(5):344-53
pubmed: 25727177
Brain Res. 2013 Jan 15;1490:225-32
pubmed: 23122880
Cortex. 2015 Mar;64:249-59
pubmed: 25522360
J Clin Psychiatry. 1997;58 Suppl 9:16-24
pubmed: 9329447
Psychoneuroendocrinology. 2001 Apr;26(3):273-85
pubmed: 11166490
Biol Psychiatry. 2000 Mar 15;47(6):512-9
pubmed: 10715357
Neuroimage. 2017 Feb 15;147:925-933
pubmed: 27988321
J Clin Psychiatry. 1992 Sep;53(9):324-6
pubmed: 1355475
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):823-8
pubmed: 24297904
Biol Psychiatry. 2019 Sep 15;86(6):421-432
pubmed: 31221426
Clin Psychol Rev. 2012 Jun;32(4):301-15
pubmed: 22459791
PLoS One. 2013;8(3):e58150
pubmed: 23536785
Ann N Y Acad Sci. 2006 Jul;1071:27-40
pubmed: 16891559
Depress Anxiety. 2010 Mar;27(3):244-51
pubmed: 20143428
Transl Psychiatry. 2019 Jul 25;9(1):178
pubmed: 31346158
Hippocampus. 2005;15(6):798-807
pubmed: 15988763
Biol Psychiatry. 2009 Dec 15;66(12):1075-82
pubmed: 19748076
Ann N Y Acad Sci. 2006 Jul;1071:137-66
pubmed: 16891568
Biol Psychol. 2014 Oct;102:10-7
pubmed: 25046862
Int J Psychophysiol. 2009 Mar;71(3):264-8
pubmed: 19013485
Arch Gen Psychiatry. 2009 Oct;66(10):1099-107
pubmed: 19805700
J Physiol. 2017 Jul 15;595(14):4893-4908
pubmed: 28503726
Arch Gen Psychiatry. 1998 Jun;55(6):553-9
pubmed: 9633675
Neurobiol Stress. 2016 Nov 23;6:44-56
pubmed: 28229108
Compr Physiol. 2016 Mar 15;6(2):603-21
pubmed: 27065163
Am J Psychiatry. 2018 Oct 1;175(10):989-998
pubmed: 30021460
Neurosci Biobehav Rev. 2012 Oct;36(9):2130-42
pubmed: 22766141
J Psychiatr Res. 2008 Jun;42(7):515-20
pubmed: 18313695
Neuropsychopharmacology. 2009 Feb;34(3):539-47
pubmed: 18235425
Ann Behav Med. 2009 Apr;37(2):141-53
pubmed: 19424767
JAMA Psychiatry. 2015 Oct;72(10):979-86
pubmed: 26353072
Brain Res. 2016 Jun 15;1641(Pt B):177-88
pubmed: 26607253
Biol Psychol. 2015 May;108:62-77
pubmed: 25843917
Dialogues Clin Neurosci. 2011;13(3):263-78
pubmed: 22034143
Behav Res Ther. 2007 Sep;45(9):2019-33
pubmed: 17442266
Biol Psychiatry. 2010 Feb 15;67(4):346-56
pubmed: 19875104
J Affect Disord. 2016 Jan 15;190:714-722
pubmed: 26600413
J Abnorm Psychol. 2016 Apr;125(3):349-55
pubmed: 26866677
Front Hum Neurosci. 2019 Jan 09;12:521
pubmed: 30687041
Neuropharmacology. 2012 Feb;62(2):695-704
pubmed: 21377482
J Couns Psychol. 2016 Oct;63(5):509-519
pubmed: 26866637
J Psychiatry Neurosci. 2013 Sep;38(5):341-8
pubmed: 23611176
Transl Psychiatry. 2017 Sep 12;7(9):e1231
pubmed: 28895942
J Psychiatry Neurosci. 2017 Sep;42(5):331-342
pubmed: 28452713
J Psychiatr Res. 2013 Jan;47(1):64-71
pubmed: 23107307
J Psychiatr Res. 2018 Jul;102:192-200
pubmed: 29684628
Psychoneuroendocrinology. 2018 Jul;93:133-141
pubmed: 29727810
Front Mol Neurosci. 2018 Dec 04;11:450
pubmed: 30564100
Am J Psychiatry. 1993 Jan;150(1):83-6
pubmed: 8417586
Eur Neuropsychopharmacol. 2017 May;27(5):515-525
pubmed: 28279623
Depress Anxiety. 2017 May;34(5):437-445
pubmed: 28294462
Psychoneuroendocrinology. 2015 Sep;59:49-58
pubmed: 26025005
Transl Psychiatry. 2015 Dec 15;5:e700
pubmed: 26670285
Am J Psychiatry. 1995 Jul;152(7):973-81
pubmed: 7793467
Psychosom Med. 2014 May;76(4):292-301
pubmed: 24804881
Am J Psychiatry. 2007 Oct;164(10):1476-88
pubmed: 17898336
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):103-17
pubmed: 12732227
Ann N Y Acad Sci. 2006 Dec;1094:202-14
pubmed: 17347352
J Trauma Stress. 2008 Apr;21(2):190-8
pubmed: 18404640
Biol Psychiatry. 2006 Apr 1;59(7):582-7
pubmed: 16165099
Biol Psychiatry. 2012 Jul 1;72(1):19-24
pubmed: 22502987
J Psychiatr Res. 2017 Nov;94:15-22
pubmed: 28633076
Neuropsychopharmacology. 2017 Jan;42(1):254-270
pubmed: 27510423
J Anxiety Disord. 2011 Mar;25(2):209-16
pubmed: 20956066
Int J Psychophysiol. 2015 Nov;98(2 Pt 2):270-275
pubmed: 25451788
Biol Mood Anxiety Disord. 2011 Oct 12;1(1):5
pubmed: 22738160
Nat Rev Neurosci. 2018 Sep;19(9):535-551
pubmed: 30054570
Rev Neurosci. 2006;17(3):279-307
pubmed: 16878401
J Abnorm Psychol. 2006 Nov;115(4):687-98
pubmed: 17100526
Biol Psychiatry. 1997 Mar 1;41(5):627-9
pubmed: 9046997
Neuroscience. 2010 Jul 14;168(3):652-8
pubmed: 20412837
J Clin Psychiatry. 2014 Oct;75(10):e1133-9
pubmed: 25373123
J Psychosom Res. 2006 Jan;60(1):83-90
pubmed: 16380314
Biol Psychol. 2018 Jul;136:161-167
pubmed: 29920297
Percept Mot Skills. 2013 Jun;116(3):707-23
pubmed: 24175446
J Abnorm Psychol. 1990 Feb;99(1):49-54
pubmed: 2307766
Biol Psychiatry. 2018 May 15;83(10):866-875
pubmed: 29628193
J Psychiatr Res. 2013 Dec;47(12):1991-7
pubmed: 24090716
Psychoneuroendocrinology. 2019 Apr;102:95-104
pubmed: 30529908
Psychoneuroendocrinology. 2016 Apr;66:47-55
pubmed: 26773400
Depress Anxiety. 2016 Apr;33(4):300-7
pubmed: 27038411
J Affect Disord. 2015 Sep 01;183:210-20
pubmed: 26025367
Sci Rep. 2016 Dec 07;6:38538
pubmed: 27924836
J Affect Disord. 2011 Jun;131(1-3):398-401
pubmed: 21093927
Depress Anxiety. 2017 Jun;34(6):502-507
pubmed: 28221710
Am J Psychiatry. 1999 Apr;156(4):585-8
pubmed: 10200738
Biol Psychiatry. 2006 May 1;59(9):872-4
pubmed: 16458259
Biol Psychiatry. 2017 Dec 15;82(12):875-884
pubmed: 28778657
Psychoneuroendocrinology. 2019 Apr;102:114-120
pubmed: 30544002
Biol Psychiatry. 1997 Jan 1;41(1):23-32
pubmed: 8988792
J Psychosom Res. 2013 Apr;74(4):301-6
pubmed: 23497831
FASEB J. 2016 Feb;30(2):519-24
pubmed: 26514164
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:51-7
pubmed: 24447944
J Abnorm Psychol. 2010 Aug;119(3):502-12
pubmed: 20677839