Epigenetic Link Between Statin Therapy and Type 2 Diabetes.

Adult Aged Blood Glucose / metabolism Cohort Studies CpG Islands / drug effects DNA Methylation / drug effects Diabetes Mellitus, Type 2 / blood Epigenesis, Genetic / drug effects Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Insulin / blood Insulin Resistance / genetics Male Middle Aged Phenotype

Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
04 2020
Historique:
received: 13 09 2019
accepted: 14 01 2020
pubmed: 9 2 2020
medline: 2 1 2021
entrez: 9 2 2020
Statut: ppublish

Résumé

To investigate the role of epigenetics in statins' diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood. Five cohort studies' participants ( Discovery ( This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins' effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to

Identifiants

DOI: 10.2337/dc19-1828 PMID: 32033992
pubmed: 32033992
pii: dc19-1828
doi: 10.2337/dc19-1828
doi:

Substances chimiques

Blood Glucose 0
Hydroxymethylglutaryl-CoA Reductase Inhibitors 0
Insulin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

875-884

Informations de copyright

© 2020 by the American Diabetes Association.

Auteurs

Carolina Ochoa-Rosales (C)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands taulant.muka@ispm.unibe.ch c.ochoarosales@erasmusmc.nl.
Centro de Vida Saludable de la Universidad de Concepción, Concepción, Chile.
ORCID: 0000-0001-8048-9165

Eliana Portilla-Fernandez (E)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Jana Nano (J)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
German Center for Diabetes Research, Neuherberg, Germany.
ORCID: 0000-0003-4731-5491

Rory Wilson (R)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

Benjamin Lehne (B)

Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.

Pashupati P Mishra (PP)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Xu Gao (X)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY.

Mohsen Ghanbari (M)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Oscar L Rueda-Ochoa (OL)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Electrocardiography Research group, School of Medicine, Universidad Industrial de Santander, Bucaramanga, Colombia.

Diana Juvinao-Quintero (D)

MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, U.K.

Marie Loh (M)

Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Weihua Zhang (W)

Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, U.K.

Jaspal S Kooner (JS)

Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, U.K.
National Heart and Lung Institute, Imperial College London, London, U.K.
Imperial College Healthcare NHS Trust, London, U.K.
MRC-PHE Centre for Environment and Health, Imperial College London, London, U.K.

Hans J Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.

Stephan B Felix (SB)

Partner Site Greifswald, German Center for Cardiovascular Research (DZHK), Greifswald, Germany.
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.

Ben Schöttker (B)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Network Aging Research, University of Heidelberg, Heidelberg, Germany.
ORCID: 0000-0002-1217-4521

Yan Zhang (Y)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Christian Gieger (C)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

Martina Müller-Nurasyid (M)

Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

Margit Heier (M)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
KORA Study Centre, University Hospital of Augsburg, Augsburg, Germany.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Alexander Teumer (A)

Partner Site Greifswald, German Center for Cardiovascular Research (DZHK), Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Network Aging Research, University of Heidelberg, Heidelberg, Germany.

Melanie Waldenberger (M)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Joyce B J van Meurs (JBJ)

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Oscar H Franco (OH)

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Trudy Voortman (T)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-2830-6813

John Chambers (J)

Department of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, U.K.
Imperial College Healthcare NHS Trust, London, U.K.
MRC-PHE Centre for Environment and Health, Imperial College London, London, U.K.

Bruno H Stricker (BH)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-3713-9762

Taulant Muka (T)

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland taulant.muka@ispm.unibe.ch c.ochoarosales@erasmusmc.nl.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Epigenetic Link Between Statin Therapy and...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Epigenetic Link Between Statin Therapy and...