A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level.
dermatology
general practice / family medicine
rheumatology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
06 Feb 2020
06 Feb 2020
Historique:
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
8
10
2020
Statut:
epublish
Résumé
We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron's papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.
Identifiants
pubmed: 32033996
pii: 13/2/e232260
doi: 10.1136/bcr-2019-232260
pmc: PMC7021146
pii:
doi:
Substances chimiques
Creatine Kinase
EC 2.7.3.2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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