The place-cell representation of volumetric space in rats.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
10
07
2019
accepted:
20
01
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
19
5
2020
Statut:
epublish
Résumé
Place cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.
Identifiants
pubmed: 32034157
doi: 10.1038/s41467-020-14611-7
pii: 10.1038/s41467-020-14611-7
pmc: PMC7005894
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
789Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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