Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
13
05
2019
accepted:
20
01
2020
entrez:
9
2
2020
pubmed:
9
2
2020
medline:
13
11
2020
Statut:
epublish
Résumé
The fatty acid synthase type II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium tuberculosis (Mtb). Due to their original structure, the identification of the (3 R)-hydroxyacyl-ACP dehydratases, HadAB and HadBC, of Mtb FAS-II complex required in-depth work. Here, we report the discovery of a third dehydratase protein, HadD
Identifiants
pubmed: 32034201
doi: 10.1038/s41598-020-58967-8
pii: 10.1038/s41598-020-58967-8
pmc: PMC7005898
doi:
Substances chimiques
Bacterial Proteins
0
Mycolic Acids
0
Hydro-Lyases
EC 4.2.1.-
Enoyl-CoA Hydratase
EC 4.2.1.17
Fatty Acid Synthase, Type II
EC 6.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2112Références
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